Liao H - Search Results

1

Pharmacological evaluation of a novel skeleton compound isobavachin (4',7-dihydroxy-8-prenylflavanone) as a hypouricemic agent: Dual actions of URAT1/GLUT9 and xanthine oxidase inhibitory activity.

Zhao Z, Luo J, Liao H, Zheng F, Chen X, Luo J, Chen Y, Zhao K, Zhang S, Tian J, Wu T, Li Y, Li L, Yang Y, Lin C, Zhang Q, Tian Y, Pang J. Zhao Z, et al. Among authors: liao h. Bioorg Chem. 2023 Apr;133:106405. doi: 10.1016/j.bioorg.2023.106405. Epub 2023 Feb 3. Bioorg Chem. 2023. PMID: 36753966

2

Discovery of novel quinazoline-based covalent inhibitors of KRAS G12C with various cysteine-targeting warheads as potential anticancer agents.

Li L, Zhao H, Liao H, Chen J, Liu J, Chen J. Li L, et al. Among authors: liao h. Bioorg Chem. 2021 May;110:104825. doi: 10.1016/j.bioorg.2021.104825. Epub 2021 Mar 13. Bioorg Chem. 2021. PMID: 33774492

3

Discovery of Novel Bicyclic Imidazolopyridine-Containing Human Urate Transporter 1 Inhibitors as Hypouricemic Drug Candidates with Improved Efficacy and Favorable Druggability.

Zhao T, Zhang J, Tao Y, Liao H, Zhao F, Liang R, Shi X, Zhang Z, Ji J, Wu T, Pang J, Liu X, Zhan P. Zhao T, et al. Among authors: liao h. J Med Chem. 2022 Mar 10;65(5):4218-4237. doi: 10.1021/acs.jmedchem.1c02057. Epub 2022 Jan 27. J Med Chem. 2022. PMID: 35084182

4

Discovery of novel benzbromarone analogs with improved pharmacokinetics and benign toxicity profiles as antihyperuricemic agents.

Zhao Z, Liu J, Yuan L, Yang Z, Kuang P, Liao H, Luo J, Feng H, Zheng F, Chen Y, Wu T, Guo J, Cao Y, Yang Y, Lin C, Zhang Q, Chen J, Pang J. Zhao Z, et al. Among authors: liao h. Eur J Med Chem. 2022 Nov 15;242:114682. doi: 10.1016/j.ejmech.2022.114682. Epub 2022 Aug 18. Eur J Med Chem. 2022. PMID: 36001935

5

Assessment of the influence on left ventricle by potassium oxonate and hypoxanthine-induced chronic hyperuricemia.

Lin C, Zheng Q, Li Y, Wu T, Luo J, Jiang Y, Huang Q, Yan C, Zhang L, Zhang W, Liao H, Yang Y, Pang J. Lin C, et al. Among authors: liao h. Exp Biol Med (Maywood). 2023 Jan;248(2):165-174. doi: 10.1177/15353702221120113. Epub 2022 Sep 12. Exp Biol Med (Maywood). 2023. PMID: 36112877 Free PMC article.

6

Mutation in Transmembrane Domain 8 of Human Urate Transporter 1 Disrupts Uric Acid Recognition and Transport.

Lan Q, Zhao Z, Liao H, Zheng F, Chen Y, Wu T, Tian Y, Pang J. Lan Q, et al. Among authors: liao h. ACS Omega. 2022 Sep 15;7(38):34621-34631. doi: 10.1021/acsomega.2c04543. eCollection 2022 Sep 27. ACS Omega. 2022. PMID: 36188325 Free PMC article.

7

Design, synthesis and activity evaluation of novel lesinurad analogues containing thienopyrimidinone or pyridine substructure as human urate transporter 1 inhibitors.

Zhang J, Dong Y, Gao S, Zhang X, Liao H, Shi X, Zhang Z, Zhao T, Liang R, Qi D, Wu T, Pang J, Liu X, Zhan P. Zhang J, et al. Among authors: liao h. Eur J Med Chem. 2022 Dec 15;244:114816. doi: 10.1016/j.ejmech.2022.114816. Epub 2022 Oct 4. Eur J Med Chem. 2022. PMID: 36219903

8

Insoluble Fiber in Barley Leaf Attenuates Hyperuricemic Nephropathy by Modulating Gut Microbiota and Short-Chain Fatty Acids.

Li Y, Li L, Tian J, Zheng F, Liao H, Zhao Z, Chen Y, Pang J, Wu T. Li Y, et al. Among authors: liao h. Foods. 2022 Nov 2;11(21):3482. doi: 10.3390/foods11213482. Foods. 2022. PMID: 36360095 Free PMC article.

9

Discovery of a Novel Thienopyrimidine Compound as a Urate Transporter 1 and Glucose Transporter 9 Dual Inhibitor with Improved Efficacy and Favorable Druggability.

Shi X, Zhao T, Wang S, Xu S, Liao H, Gao S, Gao Z, Zhang J, Qi D, Zhang Z, Zheng F, Wang Y, Wang Z, Yang M, Yang Q, Yi F, Pang J, Liu X, Zhan P. Shi X, et al. Among authors: liao h. J Med Chem. 2024 Mar 28;67(6):5032-5052. doi: 10.1021/acs.jmedchem.4c00136. Epub 2024 Mar 14. J Med Chem. 2024. PMID: 38482820

10

Discovery of digallic acid as XOD/URAT1 dual target inhibitor for the treatment of hyperuricemia.

Zheng F, Mai S, Cen X, Zhao P, Ye W, Ke J, Lin S, Hu H, Guo Z, Zhang S, Liao H, Wu T, Tian Y, Zhang Q, Pang J, Zhao Z. Zheng F, et al. Among authors: liao h. Bioorg Chem. 2024 Jun;147:107381. doi: 10.1016/j.bioorg.2024.107381. Epub 2024 Apr 23. Bioorg Chem. 2024. PMID: 38669781

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