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A low dose of RBD and TLR7/8 agonist displayed on influenza virosome particles protects rhesus macaque against SARS-CoV-2 challenge.
Koopman G, Amacker M, Stegmann T, Verschoor EJ, Verstrepen BE, Bhoelan F, Bemelman D, Böszörményi KP, Fagrouch Z, Kiemenyi-Kayere G, Mortier D, Verel DE, Niphuis H, Acar RF, Kondova I, Kap YS, Bogers WMJM, Mooij P, Fleury S. Koopman G, et al. Among authors: bhoelan f. Sci Rep. 2023 Mar 28;13(1):5074. doi: 10.1038/s41598-023-31818-y. Sci Rep. 2023. PMID: 36977691 Free PMC article.
New GMP manufacturing processes to obtain thermostable HIV-1 gp41 virosomes under solid forms for various mucosal vaccination routes.
Amacker M, Smardon C, Mason L, Sorrell J, Jeffery K, Adler M, Bhoelan F, Belova O, Spengler M, Punnamoottil B, Schwaller M, Bonduelle O, Combadière B, Stegmann T, Naylor A, Johnson R, Wong D, Fleury S. Amacker M, et al. Among authors: bhoelan f. NPJ Vaccines. 2020 May 18;5(1):41. doi: 10.1038/s41541-020-0190-9. eCollection 2020. NPJ Vaccines. 2020. PMID: 32435515 Free PMC article.
Enhanced HPV16 E6/E7+ tumor eradication via induction of tumor-specific T cells by therapeutic vaccination with virosomes presenting synthetic long peptides.
Stegmann T, Wiekmeijer AS, Kwappenberg K, van Duikeren S, Bhoelan F, Bemelman D, Beenakker TJM, Krebber WJ, Arens R, Melief CJM. Stegmann T, et al. Among authors: bhoelan f. Cancer Immunol Immunother. 2023 Aug;72(8):2851-2864. doi: 10.1007/s00262-023-03462-y. Epub 2023 May 24. Cancer Immunol Immunother. 2023. PMID: 37222770 Free PMC article.
A spike virosome vaccine induces pan-sarbecovirus antibody responses in mice.
Brinkkemper M, Poniman M, Siteur-van Rijnstra E, Iddouch WA, Bijl TPL, Guerra D, Tejjani K, Grobben M, Bhoelan F, Bemelman D, Kempers R, van Gils MJ, Sliepen K, Stegmann T, van der Velden YU, Sanders RW. Brinkkemper M, et al. Among authors: bhoelan f. iScience. 2024 Apr 10;27(5):109719. doi: 10.1016/j.isci.2024.109719. eCollection 2024 May 17. iScience. 2024. PMID: 38706848 Free PMC article.