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Identification of Z-Tyr-Ala-CHN2, a Cathepsin L Inhibitor with Broad-Spectrum Cell-Specific Activity against Coronaviruses, including SARS-CoV-2.
Doijen J, Temmerman K, Van den Eynde C, Diels A, Van den Broeck N, Van Gool M, Heo I, Jaensch S, Zwaagstra M, Diosa Toro M, Chiu W, De Jonghe S, Leyssen P, Bojkova D, Ciesek S, Cinatl J, Verschueren L, Buyck C, Van Kuppeveld F, Neyts J, Van Loock M, Van Damme E. Doijen J, et al. Among authors: van damme e, van den broeck n, van loock m, van kuppeveld f, van den eynde c, van gool m. Microorganisms. 2023 Mar 10;11(3):717. doi: 10.3390/microorganisms11030717. Microorganisms. 2023. PMID: 36985290 Free PMC article.
A novel, broad-spectrum inhibitor of enterovirus replication that targets host cell factor phosphatidylinositol 4-kinase IIIβ.
van der Schaar HM, Leyssen P, Thibaut HJ, de Palma A, van der Linden L, Lanke KH, Lacroix C, Verbeken E, Conrath K, Macleod AM, Mitchell DR, Palmer NJ, van de Poël H, Andrews M, Neyts J, van Kuppeveld FJ. van der Schaar HM, et al. Antimicrob Agents Chemother. 2013 Oct;57(10):4971-81. doi: 10.1128/AAC.01175-13. Epub 2013 Jul 29. Antimicrob Agents Chemother. 2013. PMID: 23896472 Free PMC article.
Binding of glutathione to enterovirus capsids is essential for virion morphogenesis.
Thibaut HJ, van der Linden L, Jiang P, Thys B, Canela MD, Aguado L, Rombaut B, Wimmer E, Paul A, Pérez-Pérez MJ, van Kuppeveld FJ, Neyts J. Thibaut HJ, et al. PLoS Pathog. 2014 Apr 10;10(4):e1004039. doi: 10.1371/journal.ppat.1004039. eCollection 2014 Apr. PLoS Pathog. 2014. PMID: 24722756 Free PMC article.
Itraconazole inhibits enterovirus replication by targeting the oxysterol-binding protein.
Strating JR, van der Linden L, Albulescu L, Bigay J, Arita M, Delang L, Leyssen P, van der Schaar HM, Lanke KH, Thibaut HJ, Ulferts R, Drin G, Schlinck N, Wubbolts RW, Sever N, Head SA, Liu JO, Beachy PA, De Matteis MA, Shair MD, Olkkonen VM, Neyts J, van Kuppeveld FJ. Strating JR, et al. Cell Rep. 2015 Feb 3;10(4):600-15. doi: 10.1016/j.celrep.2014.12.054. Epub 2015 Jan 29. Cell Rep. 2015. PMID: 25640182 Free PMC article.
The RNA template channel of the RNA-dependent RNA polymerase as a target for development of antiviral therapy of multiple genera within a virus family.
van der Linden L, Vives-Adrián L, Selisko B, Ferrer-Orta C, Liu X, Lanke K, Ulferts R, De Palma AM, Tanchis F, Goris N, Lefebvre D, De Clercq K, Leyssen P, Lacroix C, Pürstinger G, Coutard B, Canard B, Boehr DD, Arnold JJ, Cameron CE, Verdaguer N, Neyts J, van Kuppeveld FJ. van der Linden L, et al. Among authors: van kuppeveld fj. PLoS Pathog. 2015 Mar 23;11(3):e1004733. doi: 10.1371/journal.ppat.1004733. eCollection 2015 Mar. PLoS Pathog. 2015. PMID: 25799064 Free PMC article.
266 results