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Egg-laying and locomotory screens with C. elegans yield a nematode-selective small molecule stimulator of neurotransmitter release.
Harrington S, Knox JJ, Burns AR, Choo KL, Au A, Kitner M, Haeberli C, Pyche J, D'Amata C, Kim YH, Volpatti JR, Guiliani M, Snider J, Wong V, Palmeira BM, Redman EM, Vaidya AS, Gilleard JS, Stagljar I, Cutler SR, Kulke D, Dowling JJ, Yip CM, Keiser J, Zasada I, Lautens M, Roy PJ. Harrington S, et al. Among authors: lautens m. Commun Biol. 2022 Aug 24;5(1):865. doi: 10.1038/s42003-022-03819-6. Commun Biol. 2022. PMID: 36002479 Free PMC article.
Selective control of parasitic nematodes using bioactivated nematicides.
Burns AR, Baker RJ, Kitner M, Knox J, Cooke B, Volpatti JR, Vaidya AS, Puumala E, Palmeira BM, Redman EM, Snider J, Marwah S, Chung SW, MacDonald MH, Tiefenbach J, Hu C, Xiao Q, Finney CAM, Krause HM, MacParland SA, Stagljar I, Gilleard JS, Cowen LE, Meyer SLF, Cutler SR, Dowling JJ, Lautens M, Zasada I, Roy PJ. Burns AR, et al. Among authors: lautens m. Nature. 2023 Jun;618(7963):102-109. doi: 10.1038/s41586-023-06105-5. Epub 2023 May 24. Nature. 2023. PMID: 37225985
Cyprocide selectively kills nematodes via cytochrome P450 bioactivation.
Knox J, Burns AR, Cooke B, Cammalleri SR, Kitner M, Ching J, Castelli JMP, Puumala E, Snider J, Koury E, Collins JB, Geissah S, Dowling JJ, Andersen EC, Stagljar I, Cowen LE, Lautens M, Zasada I, Roy PJ. Knox J, et al. Among authors: lautens m. Nat Commun. 2024 Jul 2;15(1):5529. doi: 10.1038/s41467-024-49738-4. Nat Commun. 2024. PMID: 38956039 Free PMC article.
Discovery and Characterization of a Chemical Probe Targeting the Zinc-Finger Ubiquitin-Binding Domain of HDAC6.
Harding RJ, Franzoni I, Mann MK, Szewczyk MM, Mirabi B, Ferreira de Freitas R, Owens DDG, Ackloo S, Scheremetjew A, Juarez-Ornelas KA, Sanichar R, Baker RJ, Dank C, Brown PJ, Barsyte-Lovejoy D, Santhakumar V, Schapira M, Lautens M, Arrowsmith CH. Harding RJ, et al. Among authors: lautens m. J Med Chem. 2023 Aug 10;66(15):10273-10288. doi: 10.1021/acs.jmedchem.3c00314. Epub 2023 Jul 27. J Med Chem. 2023. PMID: 37499118 Free PMC article.
264 results