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The novel uncompetitive NMDA receptor antagonist esmethadone (REL-1017) has no meaningful abuse potential in recreational drug users.
Shram MJ, Henningfield JE, Apseloff G, Gorodetzky CW, De Martin S, Vocci FL, Sapienza FL, Kosten TR, Huston J, Buchhalter A, Ashworth J, Lanier R, Folli F, Mattarei A, Guidetti C, Comai S, O'Gorman C, Traversa S, Inturrisi CE, Manfredi PL, Pappagallo M. Shram MJ, et al. Among authors: gorodetzky cw. Transl Psychiatry. 2023 Jun 7;13(1):192. doi: 10.1038/s41398-023-02473-8. Transl Psychiatry. 2023. PMID: 37286536 Free PMC article. Clinical Trial.
Efficacy and Safety of Esmethadone (REL-1017) in Patients With Major Depressive Disorder and Inadequate Response to Standard Antidepressants: A Phase 3 Randomized Controlled Trial.
Fava M, Stahl SM, Pani L, De Martin S, Cutler AJ, Maletic V, Gorodetzky CW, Vocci FJ, Sapienza FL, Kosten TR, Kröger C, Champasa P, O'Gorman C, Guidetti C, Alimonti A, Comai S, Mattarei A, Folli F, Bushnell D, Traversa S, Inturrisi CE, Manfredi PL, Pappagallo M. Fava M, et al. Among authors: gorodetzky cw. J Clin Psychiatry. 2024 Jun 17;85(3):24m15265. doi: 10.4088/JCP.24m15265. J Clin Psychiatry. 2024. PMID: 38917366 Free article. Clinical Trial.
Efficacy of over-the-counter nicotine patch.
Shiffman S, Gorsline J, Gorodetzky CW. Shiffman S, et al. Among authors: gorodetzky cw. Nicotine Tob Res. 2002 Nov;4(4):477-83. doi: 10.1080/1462220021000018416. Nicotine Tob Res. 2002. PMID: 12521407 Clinical Trial.
Letter to the Editor regarding 'Unique pharmacodynamic properties and low abuse liability of the µ-opioid receptor ligand (S)-methadone'.
Pappagallo M, Kosten TR, Gorodetzky CW, Vocci FJ, Sapienza FL, De Martin S, Comai S, Mattarei A, Inturrisi CE, Manfredi PL. Pappagallo M, et al. Among authors: gorodetzky cw. Mol Psychiatry. 2024 May 28. doi: 10.1038/s41380-024-02621-6. Online ahead of print. Mol Psychiatry. 2024. PMID: 38806691 No abstract available.
A multisite, double-blind, placebo-controlled clinical trial to evaluate the safety and efficacy of vigabatrin for treating cocaine dependence.
Somoza EC, Winship D, Gorodetzky CW, Lewis D, Ciraulo DA, Galloway GP, Segal SD, Sheehan M, Roache JD, Bickel WK, Jasinski D, Watson DW, Miller SR, Somoza P, Winhusen T. Somoza EC, et al. Among authors: gorodetzky cw. JAMA Psychiatry. 2013 Jun;70(6):630-7. doi: 10.1001/jamapsychiatry.2013.872. JAMA Psychiatry. 2013. PMID: 23575810 Clinical Trial.
Risk management and post-marketing surveillance for the abuse of medications acting on the central nervous system: expert panel report.
Johanson CE, Balster RL, Henningfield JE, Schuster CR, Anthony JC, Barthwell AG, Coleman JJ, Dart RC, Gorodetzky CW, O'Keeffe C, Sellers EM, Vocci F, Walsh SL. Johanson CE, et al. Among authors: gorodetzky cw. Drug Alcohol Depend. 2009 Dec 1;105 Suppl 1(Suppl 1):S65-71. doi: 10.1016/j.drugalcdep.2009.08.006. Epub 2009 Sep 23. Drug Alcohol Depend. 2009. PMID: 19783383 Free PMC article.
66 results