Ibrahim IM - Search Results

1

Design, synthesis, docking, MD simulations, and anti-proliferative evaluation of thieno[2,3-d]pyrimidine derivatives as new EGFR inhibitors.

Sobh EA, Dahab MA, Elkaeed EB, Alsfouk AA, Ibrahim IM, Metwaly AM, Eissa IH. Sobh EA, et al. Among authors: ibrahim im. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2220579. doi: 10.1080/14756366.2023.2220579. J Enzyme Inhib Med Chem. 2023. PMID: 37288786 Free PMC article.

2

Anticancer derivative of the natural alkaloid, theobromine, inhibiting EGFR protein: Computer-aided drug discovery approach.

Eissa IH, Yousef RG, Elkaeed EB, Alsfouk AA, Husein DZ, Ibrahim IM, Alesawy MS, Elkady H, Metwaly AM. Eissa IH, et al. Among authors: ibrahim im. PLoS One. 2023 Mar 9;18(3):e0282586. doi: 10.1371/journal.pone.0282586. eCollection 2023. PLoS One. 2023. PMID: 36893122 Free PMC article.

3

Computer aided drug discovery (CADD) of a thieno[2,3-d]pyrimidine derivative as a new EGFR inhibitor targeting the ribose pocket.

Sobh EA, Dahab MA, Elkaeed EB, Alsfouk AA, Ibrahim IM, Metwaly AM, Eissa IH. Sobh EA, et al. Among authors: ibrahim im. J Biomol Struct Dyn. 2024 Mar;42(5):2369-2391. doi: 10.1080/07391102.2023.2204500. Epub 2023 May 2. J Biomol Struct Dyn. 2024. PMID: 37129193

4

New apoptotic anti-triple-negative breast cancer theobromine derivative inhibiting EGFRWT and EGFR^T790M: in silico and in vitro evaluation.

Eissa IH, G Yousef R, Elkady H, Alsfouk AA, Husein DZ, Ibrahim IM, El-Deeb N, Kenawy AM, Eldehna WM, Elkaeed EB, Metwaly AM. Eissa IH, et al. Among authors: ibrahim im. Mol Divers. 2024 Jun;28(3):1153-1173. doi: 10.1007/s11030-023-10644-4. Epub 2023 May 10. Mol Divers. 2024. PMID: 37162644

5

A novel thieno[2,3-d]pyrimidine derivative inhibiting vascular endothelial growth factor receptor-2: A story of computer-aided drug discovery.

Sobh EA, Dahab MA, Elkaeed EB, Alsfouk BA, Ibrahim IM, Metwaly AM, Eissa IH. Sobh EA, et al. Among authors: ibrahim im. Drug Dev Res. 2023 Sep;84(6):1247-1265. doi: 10.1002/ddr.22083. Epub 2023 May 26. Drug Dev Res. 2023. PMID: 37232504

6

Semi-synthesized anticancer theobromine derivatives targeting VEGFR-2: in silico and in vitro evaluations.

Dahab MA, Mahdy HA, Elkady H, Taghour MS, Elwan A, Elkady MA, Elsakka EGE, Elkaeed EB, Alsfouk AA, Ibrahim IM, Metwaly AM, Eissa IH. Dahab MA, et al. Among authors: ibrahim im. J Biomol Struct Dyn. 2024 May;42(8):4214-4233. doi: 10.1080/07391102.2023.2219333. Epub 2023 Jun 1. J Biomol Struct Dyn. 2024. PMID: 37261471

7

New theobromine derivatives inhibiting VEGFR-2: design, synthesis, antiproliferative, docking and molecular dynamics simulations.

Mahdy HA, Elkady H, Taghour MS, Elwan A, Dahab MA, Elkady MA, Elsakka EG, Elkaeed EB, Alsfouk BA, Ibrahim IM, Eissa IH, Metwaly AM. Mahdy HA, et al. Among authors: ibrahim im. Future Med Chem. 2023 Jul;15(14):1233-1250. doi: 10.4155/fmc-2023-0089. Epub 2023 Jul 19. Future Med Chem. 2023. PMID: 37466069

8

In vitro and in silico evaluation of new thieno[2,3-d]pyrimidines as anti-cancer agents and apoptosis inducers targeting VEGFR-2.

El-Metwally SA, Abuelkhir AA, Elkady H, Taghour MS, Ibrahim IM, Husein DZ, Alsfouk AA, Sultan A, Ismail A, Elkhawaga SY, Elkaeed EB, Metwaly AM, Eissa IH. El-Metwally SA, et al. Among authors: ibrahim im. Comput Biol Chem. 2023 Oct;106:107928. doi: 10.1016/j.compbiolchem.2023.107928. Epub 2023 Jul 18. Comput Biol Chem. 2023. PMID: 37480629

9

Discovery of new thieno[2,3-d]pyrimidines as EGFR tyrosine kinase inhibitors for cancer treatment.

Sobh EA, Dahab MA, Elkaeed EB, Alsfouk AA, Ibrahim IM, Metwaly AM, Eissa IH. Sobh EA, et al. Among authors: ibrahim im. Future Med Chem. 2023 Jul;15(13):1167-1184. doi: 10.4155/fmc-2023-0086. Epub 2023 Aug 2. Future Med Chem. 2023. PMID: 37529910

10

Identification of new theobromine-based derivatives as potent VEGFR-2 inhibitors: design, semi-synthesis, biological evaluation, and in silico studies.

Eissa IH, Yousef RG, Elkady H, Elkaeed EB, Alsfouk AA, Husein DZ, Ibrahim IM, Elhendawy MA, Godfrey M, Metwaly AM. Eissa IH, et al. Among authors: ibrahim im. RSC Adv. 2023 Aug 2;13(33):23285-23307. doi: 10.1039/d3ra04007k. eCollection 2023 Jul 26. RSC Adv. 2023. PMID: 37538515 Free PMC article.

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