Sobh EA - Search Results

1

Design, synthesis, docking, MD simulations, and anti-proliferative evaluation of thieno[2,3-d]pyrimidine derivatives as new EGFR inhibitors.

Sobh EA, Dahab MA, Elkaeed EB, Alsfouk AA, Ibrahim IM, Metwaly AM, Eissa IH. Sobh EA, et al. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2220579. doi: 10.1080/14756366.2023.2220579. J Enzyme Inhib Med Chem. 2023. PMID: 37288786 Free PMC article.

2

Computer aided drug discovery (CADD) of a thieno[2,3-d]pyrimidine derivative as a new EGFR inhibitor targeting the ribose pocket.

Sobh EA, Dahab MA, Elkaeed EB, Alsfouk AA, Ibrahim IM, Metwaly AM, Eissa IH. Sobh EA, et al. J Biomol Struct Dyn. 2024 Mar;42(5):2369-2391. doi: 10.1080/07391102.2023.2204500. Epub 2023 May 2. J Biomol Struct Dyn. 2024. PMID: 37129193

3

A novel thieno[2,3-d]pyrimidine derivative inhibiting vascular endothelial growth factor receptor-2: A story of computer-aided drug discovery.

Sobh EA, Dahab MA, Elkaeed EB, Alsfouk BA, Ibrahim IM, Metwaly AM, Eissa IH. Sobh EA, et al. Drug Dev Res. 2023 Sep;84(6):1247-1265. doi: 10.1002/ddr.22083. Epub 2023 May 26. Drug Dev Res. 2023. PMID: 37232504

4

Design, synthesis, docking, and anticancer evaluations of new thiazolo[3,2-a] pyrimidines as topoisomerase II inhibitors.

El-Zoghbi MS, El-Sebaey SA, Al-Ghulikah HA, Sobh EA. El-Zoghbi MS, et al. Among authors: sobh ea. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2175209. doi: 10.1080/14756366.2023.2175209. J Enzyme Inhib Med Chem. 2023. PMID: 36776024 Free PMC article.

5

New benzothieno[2,3-c]pyridines as non-steroidal CYP17 inhibitors: design, synthesis, anticancer screening, apoptosis induction, and in silico ADME profile studies.

Khalil NA, Ahmed EM, Zaher AF, Sobh EA, El-Sebaey SA, El-Zoghbi MS. Khalil NA, et al. Among authors: sobh ea. J Enzyme Inhib Med Chem. 2021 Dec;36(1):1839-1859. doi: 10.1080/14756366.2021.1958212. J Enzyme Inhib Med Chem. 2021. PMID: 34338119 Free PMC article.

6

Synthesis of certain benzothieno[3,2-d]pyrimidine derivatives as a selective SIRT2 inhibitors.

Khalil NA, Ahmed EM, Zaher AF, El-Zoghbi MS, Sobh EA. Khalil NA, et al. Among authors: sobh ea. Eur J Med Chem. 2020 Feb 1;187:111926. doi: 10.1016/j.ejmech.2019.111926. Epub 2019 Nov 30. Eur J Med Chem. 2020. PMID: 31812033

7

New benzothienopyrimidine derivatives as dual EGFR/ARO inhibitors: Design, synthesis, and their cytotoxic effect on MCF-7 breast cancer cell line.

Sobh EA, Khalil NA, Faggal SI, Hassan MSA. Sobh EA, et al. Drug Dev Res. 2022 Aug;83(5):1075-1096. doi: 10.1002/ddr.21934. Epub 2022 Mar 14. Drug Dev Res. 2022. PMID: 35286757

8

New pyrrole derivatives as DNA gyrase and 14α-demethylase inhibitors: Design, synthesis, antimicrobial evaluation, and molecular docking.

Hilmy KMH, Kishk FNM, Shahen EBA, Sobh EA, Hawata MA. Hilmy KMH, et al. Among authors: sobh ea. Drug Dev Res. 2023 Sep;84(6):1204-1230. doi: 10.1002/ddr.22080. Epub 2023 May 11. Drug Dev Res. 2023. PMID: 37165799

9

New Thieno[2,3-d]pyrimidines as Anticancer VEGFR-2 Inhibitors with Apoptosis Induction: Design, Synthesis, and Biological and In Silico Studies.

Sobh EA, Dahab MA, Elkaeed EB, Alsfouk BA, Ibrahim IM, Metwaly AM, Eissa IH. Sobh EA, et al. Med Chem. 2024;20(9):876-899. doi: 10.2174/0115734064285433240513092047. Med Chem. 2024. PMID: 38798211

10

New pyranopyrazole based derivatives: Design, synthesis, and biological evaluation as potential topoisomerase II inhibitors, apoptotic inducers, and antiproliferative agents.

Sobh EA, Kassab AE, El-Khouly EA, S A Hassan M. Sobh EA, et al. Bioorg Chem. 2024 Mar;144:107158. doi: 10.1016/j.bioorg.2024.107158. Epub 2024 Jan 29. Bioorg Chem. 2024. PMID: 38301427

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