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Mechanical activation of lung epithelial cells through the ion channel Piezo1 activates the metalloproteinases ADAM10 and ADAM17 and promotes growth factor and adhesion molecule release.
Grannemann C, Pabst A, Honert A, Schieren J, Martin C, Hank S, Böll S, Bläsius K, Düsterhöft S, Jahr H, Merkel R, Leube R, Babendreyer A, Ludwig A. Grannemann C, et al. Among authors: dusterhoft s. Biomater Adv. 2023 Sep;152:213516. doi: 10.1016/j.bioadv.2023.213516. Epub 2023 Jun 12. Biomater Adv. 2023. PMID: 37348330 Free article.
Proteolytic Origin of the Soluble Human IL-6R In Vivo and a Decisive Role of N-Glycosylation.
Riethmueller S, Somasundaram P, Ehlers JC, Hung CW, Flynn CM, Lokau J, Agthe M, Düsterhöft S, Zhu Y, Grötzinger J, Lorenzen I, Koudelka T, Yamamoto K, Pickhinke U, Wichert R, Becker-Pauly C, Rädisch M, Albrecht A, Hessefort M, Stahnke D, Unverzagt C, Rose-John S, Tholey A, Garbers C. Riethmueller S, et al. Among authors: dusterhoft s. PLoS Biol. 2017 Jan 6;15(1):e2000080. doi: 10.1371/journal.pbio.2000080. eCollection 2017 Jan. PLoS Biol. 2017. PMID: 28060820 Free PMC article.
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