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Page 1
Effects of danicamtiv, a novel cardiac myosin activator, in heart failure with reduced ejection fraction: experimental data and clinical results from a phase 2a trial.
Voors AA, Tamby JF, Cleland JG, Koren M, Forgosh LB, Gupta D, Lund LH, Camacho A, Karra R, Swart HP, Pellicori P, Wagner F, Hershberger RE, Prasad N, Anderson R, Anto A, Bell K, Edelberg JM, Fang L, Henze M, Kelly C, Kurio G, Li W, Wells K, Yang C, Teichman SL, Del Rio CL, Solomon SD. Voors AA, et al. Among authors: del rio cl. Eur J Heart Fail. 2020 Sep;22(9):1649-1658. doi: 10.1002/ejhf.1933. Epub 2020 Jul 10. Eur J Heart Fail. 2020. PMID: 32558989 Free PMC article. Clinical Trial.
Non-mitogenic FGF19 mRNA-based therapy for the treatment of experimental metabolic dysfunction-associated steatotic liver disease (MASLD).
Lopez-Pascual A, Russo-Cabrera JS, Ardaiz N, Palmer T, Graham AR, Uriarte I, Gomar C, Ruiz-Guillamon D, Latasa MU, Arechederra M, Fontanellas A, Monte MJ, Marin JJG, Berasain C, Del Rio CL, Fernandez-Barrena MG, Martini PGV, Schultz JR, Berraondo P, Avila MA. Lopez-Pascual A, et al. Among authors: del rio cl. Clin Sci (Lond). 2024 Oct 16;138(20):1265-1284. doi: 10.1042/CS20241137. Clin Sci (Lond). 2024. PMID: 39301694
Myosin in autoinhibited off state(s), stabilized by mavacamten, can be recruited via inotropic effectors.
Ma W, Del Rio CL, Qi L, Prodanovic M, Mijailovich S, Zambataro C, Gong H, Shimkunas R, Gollapudi S, Nag S, Irving TC. Ma W, et al. Among authors: del rio cl. bioRxiv [Preprint]. 2023 Aug 28:2023.04.10.536292. doi: 10.1101/2023.04.10.536292. bioRxiv. 2023. Update in: Proc Natl Acad Sci U S A. 2024 Feb 20;121(8):e2314914121. doi: 10.1073/pnas.2314914121. PMID: 37090664 Free PMC article. Updated. Preprint.
27 results