Spudich JA - Search Results

1

Mavacamten, a precision medicine for hypertrophic cardiomyopathy: From a motor protein to patients.

Nag S, Gollapudi SK, Del Rio CL, Spudich JA, McDowell R. Nag S, et al. Among authors: spudich ja. Sci Adv. 2023 Jul 28;9(30):eabo7622. doi: 10.1126/sciadv.abo7622. Epub 2023 Jul 28. Sci Adv. 2023. PMID: 37506209 Free article. Review.

2

Cell-intrinsic functional effects of the α-cardiac myosin Arg-403-Gln mutation in familial hypertrophic cardiomyopathy.

Chuan P, Sivaramakrishnan S, Ashley EA, Spudich JA. Chuan P, et al. Among authors: spudich ja. Biophys J. 2012 Jun 20;102(12):2782-90. doi: 10.1016/j.bpj.2012.04.049. Epub 2012 Jun 19. Biophys J. 2012. PMID: 22735528 Free PMC article.

3

Molecular consequences of the R453C hypertrophic cardiomyopathy mutation on human β-cardiac myosin motor function.

Sommese RF, Sung J, Nag S, Sutton S, Deacon JC, Choe E, Leinwand LA, Ruppel K, Spudich JA. Sommese RF, et al. Among authors: spudich ja. Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12607-12. doi: 10.1073/pnas.1309493110. Epub 2013 Jun 24. Proc Natl Acad Sci U S A. 2013. PMID: 23798412 Free PMC article.

4

Effects of troponin T cardiomyopathy mutations on the calcium sensitivity of the regulated thin filament and the actomyosin cross-bridge kinetics of human β-cardiac myosin.

Sommese RF, Nag S, Sutton S, Miller SM, Spudich JA, Ruppel KM. Sommese RF, et al. Among authors: spudich ja. PLoS One. 2013 Dec 18;8(12):e83403. doi: 10.1371/journal.pone.0083403. eCollection 2013. PLoS One. 2013. PMID: 24367593 Free PMC article.

5

Mechanistic heterogeneity in contractile properties of α-tropomyosin (TPM1) mutants associated with inherited cardiomyopathies.

Gupte TM, Haque F, Gangadharan B, Sunitha MS, Mukherjee S, Anandhan S, Rani DS, Mukundan N, Jambekar A, Thangaraj K, Sowdhamini R, Sommese RF, Nag S, Spudich JA, Mercer JA. Gupte TM, et al. Among authors: spudich ja. J Biol Chem. 2015 Mar 13;290(11):7003-15. doi: 10.1074/jbc.M114.596676. Epub 2014 Dec 29. J Biol Chem. 2015. PMID: 25548289 Free PMC article.

6

The myosin mesa and a possible unifying hypothesis for the molecular basis of human hypertrophic cardiomyopathy.

Spudich JA. Spudich JA. Biochem Soc Trans. 2015 Feb;43(1):64-72. doi: 10.1042/BST20140324. Biochem Soc Trans. 2015. PMID: 25619247 Free PMC article.

7

Harmonic force spectroscopy measures load-dependent kinetics of individual human β-cardiac myosin molecules.

Sung J, Nag S, Mortensen KI, Vestergaard CL, Sutton S, Ruppel K, Flyvbjerg H, Spudich JA. Sung J, et al. Among authors: spudich ja. Nat Commun. 2015 Aug 4;6:7931. doi: 10.1038/ncomms8931. Nat Commun. 2015. PMID: 26239258 Free PMC article.

8

Establishing disease causality for a novel gene variant in familial dilated cardiomyopathy using a functional in-vitro assay of regulated thin filaments and human cardiac myosin.

Pan S, Sommese RF, Sallam KI, Nag S, Sutton S, Miller SM, Spudich JA, Ruppel KM, Ashley EA. Pan S, et al. Among authors: spudich ja. BMC Med Genet. 2015 Oct 26;16:97. doi: 10.1186/s12881-015-0243-5. BMC Med Genet. 2015. PMID: 26498512 Free PMC article.

9

Contractility parameters of human β-cardiac myosin with the hypertrophic cardiomyopathy mutation R403Q show loss of motor function.

Nag S, Sommese RF, Ujfalusi Z, Combs A, Langer S, Sutton S, Leinwand LA, Geeves MA, Ruppel KM, Spudich JA. Nag S, et al. Among authors: spudich ja. Sci Adv. 2015 Oct 9;1(9):e1500511. doi: 10.1126/sciadv.1500511. eCollection 2015 Oct. Sci Adv. 2015. PMID: 26601291 Free PMC article.

10

Effects of hypertrophic and dilated cardiomyopathy mutations on power output by human β-cardiac myosin.

Spudich JA, Aksel T, Bartholomew SR, Nag S, Kawana M, Yu EC, Sarkar SS, Sung J, Sommese RF, Sutton S, Cho C, Adhikari AS, Taylor R, Liu C, Trivedi D, Ruppel KM. Spudich JA, et al. J Exp Biol. 2016 Jan;219(Pt 2):161-7. doi: 10.1242/jeb.125930. J Exp Biol. 2016. PMID: 26792326 Free PMC article. Review.

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