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A widely distributed gene cluster compensates for uricase loss in hominids.
Liu Y, Jarman JB, Low YS, Augustijn HE, Huang S, Chen H, DeFeo ME, Sekiba K, Hou BH, Meng X, Weakley AM, Cabrera AV, Zhou Z, van Wezel G, Medema MH, Ganesan C, Pao AC, Gombar S, Dodd D. Liu Y, et al. Among authors: medema mh. Cell. 2023 Aug 3;186(16):3400-3413.e20. doi: 10.1016/j.cell.2023.06.010. Cell. 2023. PMID: 37541197 Free PMC article.
Metabolome-guided genome mining of RiPP natural products.
Zdouc MM, van der Hooft JJJ, Medema MH. Zdouc MM, et al. Among authors: medema mh. Trends Pharmacol Sci. 2023 Aug;44(8):532-541. doi: 10.1016/j.tips.2023.06.004. Epub 2023 Jun 29. Trends Pharmacol Sci. 2023. PMID: 37391295 Review.
Genome mining of metabolic gene clusters in the Rubiaceae family.
Correia de Lemos SM, Paschoal AR, Guyot R, Medema M, Domingues DS. Correia de Lemos SM, et al. Comput Struct Biotechnol J. 2023 Nov 20;23:22-33. doi: 10.1016/j.csbj.2023.11.034. eCollection 2024 Dec. Comput Struct Biotechnol J. 2023. PMID: 38075396 Free PMC article.
OsCYP706C2 diverts rice strigolactone biosynthesis to a noncanonical pathway branch.
Li C, Haider I, Wang JY, Quinodoz P, Suarez Duran HG, Méndez LR, Horber R, Fiorilli V, Votta C, Lanfranco L, Correia de Lemos SM, Jouffroy L, Moegle B, Miesch L, De Mesmaeker A, Medema MH, Al-Babili S, Dong L, Bouwmeester HJ. Li C, et al. Among authors: medema mh. Sci Adv. 2024 Aug 30;10(35):eadq3942. doi: 10.1126/sciadv.adq3942. Epub 2024 Aug 28. Sci Adv. 2024. PMID: 39196928 Free PMC article.
154 results