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AAV-vectored expression of monospecific or bispecific monoclonal antibodies protects mice from lethal Pseudomonas aeruginosa pneumonia.
Lopes JA, Garnier NE, Pei Y, Yates JGE, Campbell ESB, Goens MM, Hughes ME, Rghei AD, Stevens BAY, Guilleman MM, Thompson B, Khursigara CM, Susta L, Wootton SK. Lopes JA, et al. Among authors: rghei ad. Gene Ther. 2024 Jul;31(7-8):400-412. doi: 10.1038/s41434-024-00453-1. Epub 2024 Apr 27. Gene Ther. 2024. PMID: 38678160
AAV-monoclonal antibody expression protects mice from Ebola virus without impeding the endogenous antibody response to heterologous challenge.
van Lieshout LP, Rghei AD, Cao W, He S, Soule G, Zhu W, Thomas SP, Sorensen D, Frost K, Tierney K, Thompson B, Booth S, Safronetz D, Kulkarni RR, Bridle BW, Qiu X, Banadyga L, Wootton SK. van Lieshout LP, et al. Among authors: rghei ad. Mol Ther Methods Clin Dev. 2022 Aug 12;26:505-518. doi: 10.1016/j.omtm.2022.08.003. eCollection 2022 Sep 8. Mol Ther Methods Clin Dev. 2022. PMID: 36092367 Free PMC article.
Adeno-associated virus mediated expression of monoclonal antibody MR191 protects mice against Marburg virus and provides long-term expression in sheep.
Rghei AD, van Lieshout LP, Cao W, He S, Tierney K, Lopes JA, Zielinska N, Baracuhy EM, Campbell ESB, Minott JA, Guilleman MM, Hasson PC, Thompson B, Karimi K, Bridle BW, Susta L, Qiu X, Banadyga L, Wootton SK. Rghei AD, et al. Gene Ther. 2022 Sep 1. doi: 10.1038/s41434-022-00361-2. Online ahead of print. Gene Ther. 2022. PMID: 36050451
AAV-Vectored Expression of the Vascular Normalizing Agents 3TSR and Fc3TSR, and the Anti-Angiogenic Bevacizumab Extends Survival in a Murine Model of End-Stage Epithelial Ovarian Carcinoma.
Stegelmeier AA, Santry LA, Guilleman MM, Matuszewska K, Minott JA, Yates JGE, Stevens BAY, Thomas SP, Vanderkamp S, Hanada K, Pei Y, Rghei AD, van Vloten JP, Pereira M, Thompson B, Major PP, Petrik JJ, Bridle BW, Wootton SK. Stegelmeier AA, et al. Among authors: rghei ad. Biomedicines. 2022 Feb 2;10(2):362. doi: 10.3390/biomedicines10020362. Biomedicines. 2022. PMID: 35203573 Free PMC article.
Safety and Tolerability of the Adeno-Associated Virus Vector, AAV6.2FF, Expressing a Monoclonal Antibody in Murine and Ovine Animal Models.
Rghei AD, van Lieshout LP, McLeod BM, Pei Y, Lopes JA, Zielinska N, Baracuhy EM, Stevens BAY, Thomas SP, Yates JGE, Warner BM, Kobasa D, Fausther-Bovendo H, Kobinger GP, Karimi K, Thompson B, Bridle BW, Susta L, Wootton SK. Rghei AD, et al. Biomedicines. 2021 Sep 9;9(9):1186. doi: 10.3390/biomedicines9091186. Biomedicines. 2021. PMID: 34572372 Free PMC article.
15 results