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Page 1
C9orf72-ALS human iPSC microglia are pro-inflammatory and toxic to co-cultured motor neurons via MMP9.
Vahsen BF, Nalluru S, Morgan GR, Farrimond L, Carroll E, Xu Y, Cramb KML, Amein B, Scaber J, Katsikoudi A, Candalija A, Carcolé M, Dafinca R, Isaacs AM, Wade-Martins R, Gray E, Turner MR, Cowley SA, Talbot K. Vahsen BF, et al. Among authors: cramb kml. Nat Commun. 2023 Sep 22;14(1):5898. doi: 10.1038/s41467-023-41603-0. Nat Commun. 2023. PMID: 37736756 Free PMC article.
Calcium dysregulation combined with mitochondrial failure and electrophysiological maturity converge in Parkinson's iPSC-dopamine neurons.
Beccano-Kelly DA, Cherubini M, Mousba Y, Cramb KML, Giussani S, Caiazza MC, Rai P, Vingill S, Bengoa-Vergniory N, Ng B, Corda G, Banerjee A, Vowles J, Cowley S, Wade-Martins R. Beccano-Kelly DA, et al. Among authors: cramb kml. iScience. 2023 Jun 7;26(7):107044. doi: 10.1016/j.isci.2023.107044. eCollection 2023 Jul 21. iScience. 2023. PMID: 37426342 Free PMC article.
Mitochondrial dysfunction and mitophagy defects in LRRK2-R1441C Parkinson's disease models.
Williamson MG, Madureira M, McGuinness W, Heon-Roberts R, Mock ED, Naidoo K, Cramb KML, Caiazza MC, Malpartida AB, Lavelle M, Savory K, Humble SW, Patterson R, Davis JB, Connor-Robson N, Ryan BJ, Wade-Martins R. Williamson MG, et al. Among authors: cramb kml. Hum Mol Genet. 2023 Sep 5;32(18):2808-2821. doi: 10.1093/hmg/ddad102. Hum Mol Genet. 2023. PMID: 37384414 Free PMC article.
Impaired dopamine release in Parkinson's disease.
Cramb KML, Beccano-Kelly D, Cragg SJ, Wade-Martins R. Cramb KML, et al. Brain. 2023 Aug 1;146(8):3117-3132. doi: 10.1093/brain/awad064. Brain. 2023. PMID: 36864664 Free PMC article. Review.
FASN-Dependent Lipid Metabolism Links Neurogenic Stem/Progenitor Cell Activity to Learning and Memory Deficits.
Bowers M, Liang T, Gonzalez-Bohorquez D, Zocher S, Jaeger BN, Kovacs WJ, Röhrl C, Cramb KML, Winterer J, Kruse M, Dimitrieva S, Overall RW, Wegleiter T, Najmabadi H, Semenkovich CF, Kempermann G, Földy C, Jessberger S. Bowers M, et al. Among authors: cramb kml. Cell Stem Cell. 2020 Jul 2;27(1):98-109.e11. doi: 10.1016/j.stem.2020.04.002. Epub 2020 May 7. Cell Stem Cell. 2020. PMID: 32386572 Free article.