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Page 1
Tonsils are major sites of persistence of SARS-CoV-2 in children.
Lima TM, Martins RB, Miura CS, Souza MVO, Cassiano MHA, Rodrigues TS, Veras FP, Sousa JF, Gomes R, Almeida GM, Melo SR, Silva GCD, Dias M, Capato CF, Silva ML, Luiz VEDB, Carenzi LR, Zamboni DS, Jorge DMM, Cunha FQ, Tamashiro E, Anselmo-Lima WT, Valera FCP, Arruda E. Lima TM, et al. Among authors: rodrigues ts. Microbiol Spectr. 2023 Sep 22;11(5):e0134723. doi: 10.1128/spectrum.01347-23. Online ahead of print. Microbiol Spectr. 2023. PMID: 37737615 Free PMC article.
Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients.
Rodrigues TS, de Sá KSG, Ishimoto AY, Becerra A, Oliveira S, Almeida L, Gonçalves AV, Perucello DB, Andrade WA, Castro R, Veras FP, Toller-Kawahisa JE, Nascimento DC, de Lima MHF, Silva CMS, Caetite DB, Martins RB, Castro IA, Pontelli MC, de Barros FC, do Amaral NB, Giannini MC, Bonjorno LP, Lopes MIF, Santana RC, Vilar FC, Auxiliadora-Martins M, Luppino-Assad R, de Almeida SCL, de Oliveira FR, Batah SS, Siyuan L, Benatti MN, Cunha TM, Alves-Filho JC, Cunha FQ, Cunha LD, Frantz FG, Kohlsdorf T, Fabro AT, Arruda E, de Oliveira RDR, Louzada-Junior P, Zamboni DS. Rodrigues TS, et al. J Exp Med. 2021 Mar 1;218(3):e20201707. doi: 10.1084/jem.20201707. J Exp Med. 2021. PMID: 33231615 Free PMC article.
Beneficial effects of colchicine for moderate to severe COVID-19: a randomised, double-blinded, placebo-controlled clinical trial.
Lopes MI, Bonjorno LP, Giannini MC, Amaral NB, Menezes PI, Dib SM, Gigante SL, Benatti MN, Rezek UC, Emrich-Filho LL, Sousa BAA, Almeida SCL, Luppino Assad R, Veras FP, Schneider A, Rodrigues TS, Leiria LOS, Cunha LD, Alves-Filho JC, Cunha TM, Arruda E, Miranda CH, Pazin-Filho A, Auxiliadora-Martins M, Borges MC, Fonseca BAL, Bollela VR, Del-Ben CM, Cunha FQ, Zamboni DS, Santana RC, Vilar FC, Louzada-Junior P, Oliveira RDR. Lopes MI, et al. Among authors: rodrigues ts. RMD Open. 2021 Feb;7(1):e001455. doi: 10.1136/rmdopen-2020-001455. RMD Open. 2021. PMID: 33542047 Free PMC article. Clinical Trial.
Efferocytosis of SARS-CoV-2-infected dying cells impairs macrophage anti-inflammatory functions and clearance of apoptotic cells.
Salina ACG, Dos-Santos D, Rodrigues TS, Fortes-Rocha M, Freitas-Filho EG, Alzamora-Terrel DL, Castro IMS, Fraga da Silva TFC, de Lima MHF, Nascimento DC, Silva CM, Toller-Kawahisa JE, Becerra A, Oliveira S, Caetité DB, Almeida L, Ishimoto AY, Lima TM, Martins RB, Veras F, do Amaral NB, Giannini MC, Bonjorno LP, Lopes MIF, Benatti MN, Batah SS, Santana RC, Vilar FC, Martins MA, Assad RL, de Almeida SCL, de Oliveira FR, Arruda Neto E, Cunha TM, Alves-Filho JC, Bonato VLD, Cunha FQ, Fabro AT, Nakaya HI, Zamboni DS, Louzada-Junior P, Oliveira RDR, Cunha LD. Salina ACG, et al. Among authors: rodrigues ts. Elife. 2022 Jun 6;11:e74443. doi: 10.7554/eLife.74443. Elife. 2022. PMID: 35666101 Free PMC article.
Gasdermin-D activation by SARS-CoV-2 triggers NET and mediate COVID-19 immunopathology.
Silva CMS, Wanderley CWS, Veras FP, Gonçalves AV, Lima MHF, Toller-Kawahisa JE, Gomes GF, Nascimento DC, Monteiro VVS, Paiva IM, Almeida CJLR, Caetité DB, Silva JC, Lopes MIF, Bonjorno LP, Giannini MC, Amaral NB, Benatti MN, Santana RC, Damasceno LEA, Silva BMS, Schneider AH, Castro IMS, Silva JCS, Vasconcelos AP, Gonçalves TT, Batah SS, Rodrigues TS, Costa VF, Pontelli MC, Martins RB, Martins TV, Espósito DLA, Cebinelli GCM, da Fonseca BAL, Leiria LOS, Cunha LD, Arruda E, Nakaia HI, Fabro AT, Oliveira RDR, Zamboni DS, Louzada-Junior P, Cunha TM, Alves-Filho JCF, Cunha FQ. Silva CMS, et al. Among authors: rodrigues ts. Crit Care. 2022 Jul 7;26(1):206. doi: 10.1186/s13054-022-04062-5. Crit Care. 2022. PMID: 35799268 Free PMC article.
Identification of immunomodulatory drugs that inhibit multiple inflammasomes and impair SARS-CoV-2 infection.
de Almeida L, da Silva ALN, Rodrigues TS, Oliveira S, Ishimoto AY, Seribelli AA, Becerra A, Andrade WA, Ataide MA, Caetano CCS, de Sá KSG, Pelisson N, Martins RB, de Paula Souza J, Arruda E, Batah SS, Castro R, Frantz FG, Cunha FQ, Cunha TM, Fabro AT, Cunha LD, Louzada-Junior P, de Oliveira RDR, Zamboni DS. de Almeida L, et al. Among authors: rodrigues ts. Sci Adv. 2022 Sep 16;8(37):eabo5400. doi: 10.1126/sciadv.abo5400. Epub 2022 Sep 14. Sci Adv. 2022. PMID: 36103544 Free PMC article.
CASP4/11 Contributes to NLRP3 Activation and COVID-19 Exacerbation.
Rodrigues TS, Caetano CCS, de Sá KSG, Almeida L, Becerra A, Gonçalves AV, Lopes LS, Oliveira S, Mascarenhas DPA, Batah SS, Silva BM, Gomes GF, Castro R, Martins RB, Avila J, Frantz FG, Cunha TM, Arruda E, Cunha FQ, Nakaya H, Cunha LD, Fabro AT, Louzada-Junior P, de Oliveira RDR, Zamboni DS. Rodrigues TS, et al. J Infect Dis. 2023 Jun 15;227(12):1364-1375. doi: 10.1093/infdis/jiad037. J Infect Dis. 2023. PMID: 36763010
Colchicine reduces the activation of NLRP3 inflammasome in COVID-19 patients.
Amaral NB, Rodrigues TS, Giannini MC, Lopes MI, Bonjorno LP, Menezes PISO, Dib SM, Gigante SLG, Benatti MN, Rezek UC, Emrich-Filho LL, Sousa BA, Almeida SCL, Luppino-Assad R, Veras FP, Schneider AH, Leiria LOS, Cunha LD, Alves-Filho JC, Cunha TM, Arruda E, Miranda CH, Pazin-Filho A, Auxiliadora-Martins M, Borges MC, Fonseca BAL, Bollela VR, Del-Ben CM, Cunha FQ, Santana RC, Vilar FC, Zamboni DS, Louzada-Junior P, Oliveira RDR. Amaral NB, et al. Among authors: rodrigues ts. Inflamm Res. 2023 May;72(5):895-899. doi: 10.1007/s00011-023-01718-y. Epub 2023 Mar 14. Inflamm Res. 2023. PMID: 36917217 Free PMC article. Clinical Trial.
C5aR1 signaling triggers lung immunopathology in COVID-19 through neutrophil extracellular traps.
Silva BM, Gomes GF, Veras FP, Cambier S, Silva GV, Quadros AU, Caetité DB, Nascimento DC, Silva CM, Silva JC, Damasceno S, Schneider AH, Beretta F, Batah SS, Castro IM, Paiva IM, Rodrigues T, Salina A, Martins R, Cebinelli GC, Bibo NL, Jorge DM, Nakaya HI, Zamboni DS, Leiria LO, Fabro AT, Alves-Filho JC, Arruda E, Louzada-Junior P, Oliveira RD, Cunha LD, Van Mol P, Vanderbeke L, Feys S, Wauters E, Brandolini L, Aramini A, Cunha FQ, Köhl J, Allegretti M, Lambrechts D, Wauters J, Proost P, Cunha TM. Silva BM, et al. J Clin Invest. 2023 Jun 15;133(12):e163105. doi: 10.1172/JCI163105. J Clin Invest. 2023. PMID: 37104043 Free PMC article.
The TIGIT+ T regulatory cells subset associates with nosocomial infection and fatal outcome in COVID-19 patients under mechanical ventilation.
de Lima MHF, Machado CC, Nascimento DC, Silva CMS, Toller-Kawahisa JE, Rodrigues TS, Veras FP, Pontelli MC, Castro IA, Zamboni DS, Filho JA, Cunha TM, Arruda E, da Cunha LD, Oliveira RDR, Cunha FQ, Louzada-Junior P. de Lima MHF, et al. Among authors: rodrigues ts. Sci Rep. 2023 Aug 21;13(1):13599. doi: 10.1038/s41598-023-39924-7. Sci Rep. 2023. PMID: 37604833 Free PMC article.
80 results