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A diet-dependent host metabolite shapes the gut microbiota to protect from autoimmunity.
Alexander M, Upadhyay V, Rock R, Ramirez L, Trepka K, Puchalska P, Orellana D, Ang QY, Whitty C, Turnbaugh JA, Tian Y, Dumlao D, Nayak R, Patterson A, Newman JC, Crawford PA, Turnbaugh PJ. Alexander M, et al. Among authors: puchalska p. bioRxiv [Preprint]. 2024 May 13:2023.11.02.565382. doi: 10.1101/2023.11.02.565382. bioRxiv. 2024. PMID: 37961209 Free PMC article. Preprint.
Ketolysis is Required for the Proper Development and Function of the Somatosensory Nervous System.
Enders J, Jack J, Thomas S, Lynch P, Lasnier S, Cao X, Swanson MT, Ryals JM, Thyfault JP, Puchalska P, Crawford PA, Wright DE. Enders J, et al. Among authors: puchalska p. bioRxiv [Preprint]. 2023 Mar 30:2023.01.11.523492. doi: 10.1101/2023.01.11.523492. bioRxiv. 2023. Update in: Exp Neurol. 2023 Jul;365:114428. doi: 10.1016/j.expneurol.2023.114428. PMID: 36711538 Free PMC article. Updated. Preprint.
Mitochondrial citrate metabolism and efflux regulates trophoblast differentiation.
Mahr RM, Jena S, Nashif SK, Nelson AB, Rauckhorst AJ, Rome FI, Sheldon RD, Hughey CC, Puchalska P, Gearhart MD, Taylor EB, Crawford PA, Wernimont SA. Mahr RM, et al. Among authors: puchalska p. bioRxiv [Preprint]. 2023 Jan 22:2023.01.22.525071. doi: 10.1101/2023.01.22.525071. bioRxiv. 2023. Update in: Sci Rep. 2023 May 6;13(1):7387. doi: 10.1038/s41598-023-34435-x. PMID: 36711862 Free PMC article. Updated. Preprint.
Metformin impairs trophoblast metabolism and differentiation in dose dependent manner.
Nashif SK, Mahr RM, Jena S, Jo S, Nelson AB, Sadowski D, Crawford PA, Puchalska P, Alejandro EU, Gearhart MD, Wernimont SA. Nashif SK, et al. Among authors: puchalska p. bioRxiv [Preprint]. 2023 Feb 17:2023.02.14.528531. doi: 10.1101/2023.02.14.528531. bioRxiv. 2023. Update in: Front Cell Dev Biol. 2023 May 12;11:1167097. doi: 10.3389/fcell.2023.1167097. PMID: 36824783 Free PMC article. Updated. Preprint.
Metabolic Messengers: ketone bodies.
Nelson AB, Queathem ED, Puchalska P, Crawford PA. Nelson AB, et al. Among authors: puchalska p. Nat Metab. 2023 Dec;5(12):2062-2074. doi: 10.1038/s42255-023-00935-3. Epub 2023 Dec 13. Nat Metab. 2023. PMID: 38092961 Review.
Loss of hepatic phosphoenolpyruvate carboxykinase 1 dysregulates metabolic responses to acute exercise but enhances adaptations to exercise training in mice.
Rome FI, Shobert GL, Voigt WC, Stagg DB, Puchalska P, Burgess SC, Crawford PA, Hughey CC. Rome FI, et al. Among authors: puchalska p. Am J Physiol Endocrinol Metab. 2023 Jan 1;324(1):E9-E23. doi: 10.1152/ajpendo.00222.2022. Epub 2022 Nov 9. Am J Physiol Endocrinol Metab. 2023. PMID: 36351254 Free PMC article.
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