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Page 1
Early vascular aging in chronic kidney disease: focus on microvascular maintenance, senescence signature and potential therapeutics.
Arefin S, Mudrovcic N, Hobson S, Pietrocola F, Ebert T, Ward LJ, Witasp A, Hernandez L, Wennberg L, Lundgren T, Steinmetz-Späh J, Larsson K, Thorell A, Bruno S, Marengo M, Cantaluppi V, Stenvinkel P, Kublickiene K. Arefin S, et al. Among authors: steinmetz spah j. Transl Res. 2024 Nov 5;275:32-47. doi: 10.1016/j.trsl.2024.11.001. Online ahead of print. Transl Res. 2024. PMID: 39510246 Free article.
High-content screening of drug combinations of an mPGES-1 inhibitor in multicellular tumor spheroids leads to mechanistic insights into neuroblastoma chemoresistance.
Zaghmi A, Aybay E, Jiang L, Shang M, Steinmetz-Späh J, Wermeling F, Kogner P, Korotkova M, Östling P, Jakobsson PJ, Seashore-Ludlow B, Larsson K. Zaghmi A, et al. Among authors: steinmetz spah j. Mol Oncol. 2024 Feb;18(2):317-335. doi: 10.1002/1878-0261.13502. Epub 2023 Aug 21. Mol Oncol. 2024. PMID: 37519014 Free PMC article.
Biosynthesis of prostaglandin 15dPGJ2 -glutathione and 15dPGJ2-cysteine conjugates in macrophages and mast cells via MGST3.
Steinmetz-Späh J, Liu J, Singh R, Ekoff M, Boddul S, Tang X, Bergqvist F, Idborg H, Heitel P, Rönnberg E, Merk D, Wermeling F, Haeggström JZ, Nilsson G, Steinhilber D, Larsson K, Korotkova M, Jakobsson PJ. Steinmetz-Späh J, et al. J Lipid Res. 2022 Dec;63(12):100310. doi: 10.1016/j.jlr.2022.100310. Epub 2022 Nov 9. J Lipid Res. 2022. PMID: 36370807 Free PMC article.
Disruption of Prostaglandin E2 Signaling in Cancer-Associated Fibroblasts Limits Mammary Carcinoma Growth but Promotes Metastasis.
Elwakeel E, Brüggemann M, Wagih J, Lityagina O, Elewa MAF, Han Y, Frömel T, Popp R, Nicolas AM, Schreiber Y, Gradhand E, Thomas D, Nüsing R, Steinmetz-Späh J, Savai R, Fokas E, Fleming I, Greten FR, Zarnack K, Brüne B, Weigert A. Elwakeel E, et al. Among authors: steinmetz spah j. Cancer Res. 2022 Apr 1;82(7):1380-1395. doi: 10.1158/0008-5472.CAN-21-2116. Cancer Res. 2022. PMID: 35105690