Kleinstiver BP - Search Results

1

Optimization of base editors for the functional correction of SMN2 as a treatment for spinal muscular atrophy.

Alves CRR, Ha LL, Yaworski R, Sutton ER, Lazzarotto CR, Christie KA, Reilly A, Beauvais A, Doll RM, de la Cruz D, Maguire CA, Swoboda KJ, Tsai SQ, Kothary R, Kleinstiver BP. Alves CRR, et al. Among authors: kleinstiver bp. Nat Biomed Eng. 2024 Feb;8(2):118-131. doi: 10.1038/s41551-023-01132-z. Epub 2023 Dec 6. Nat Biomed Eng. 2024. PMID: 38057426 Free PMC article.

2

The I-TevI nuclease and linker domains contribute to the specificity of monomeric TALENs.

Kleinstiver BP, Wang L, Wolfs JM, Kolaczyk T, McDowell B, Wang X, Schild-Poulter C, Bogdanove AJ, Edgell DR. Kleinstiver BP, et al. G3 (Bethesda). 2014 Apr 16;4(6):1155-65. doi: 10.1534/g3.114.011445. G3 (Bethesda). 2014. PMID: 24739648 Free PMC article.

3

Estimating the evidence of selection and the reliability of inference in unigenic evolution.

Fernandes AD, Kleinstiver BP, Edgell DR, Wahl LM, Gloor GB. Fernandes AD, et al. Among authors: kleinstiver bp. Algorithms Mol Biol. 2010 Nov 8;5:35. doi: 10.1186/1748-7188-5-35. Algorithms Mol Biol. 2010. PMID: 21059250 Free PMC article.

4

A unified genetic, computational and experimental framework identifies functionally relevant residues of the homing endonuclease I-BmoI.

Kleinstiver BP, Fernandes AD, Gloor GB, Edgell DR. Kleinstiver BP, et al. Nucleic Acids Res. 2010 Apr;38(7):2411-27. doi: 10.1093/nar/gkp1223. Epub 2010 Jan 8. Nucleic Acids Res. 2010. PMID: 20061372 Free PMC article.

5

The monomeric GIY-YIG homing endonuclease I-BmoI uses a molecular anchor and a flexible tether to sequentially nick DNA.

Kleinstiver BP, Wolfs JM, Edgell DR. Kleinstiver BP, et al. Nucleic Acids Res. 2013 May 1;41(10):5413-27. doi: 10.1093/nar/gkt186. Epub 2013 Apr 4. Nucleic Acids Res. 2013. PMID: 23558745 Free PMC article.

6

Rapid screening of endonuclease target site preference using a modified bacterial two-plasmid selection.

Wolfs JM, Kleinstiver BP, Edgell DR. Wolfs JM, et al. Among authors: kleinstiver bp. Methods Mol Biol. 2014;1123:97-104. doi: 10.1007/978-1-62703-968-0_8. Methods Mol Biol. 2014. PMID: 24510263

7

Strand-specific contacts and divalent metal ion regulate double-strand break formation by the GIY-YIG homing endonuclease I-BmoI.

Carter JM, Friedrich NC, Kleinstiver B, Edgell DR. Carter JM, et al. J Mol Biol. 2007 Nov 23;374(2):306-21. doi: 10.1016/j.jmb.2007.09.027. Epub 2007 Sep 16. J Mol Biol. 2007. PMID: 17936302

8

Divalent metal ion differentially regulates the sequential nicking reactions of the GIY-YIG homing endonuclease I-BmoI.

Kleinstiver BP, Bérubé-Janzen W, Fernandes AD, Edgell DR. Kleinstiver BP, et al. PLoS One. 2011;6(8):e23804. doi: 10.1371/journal.pone.0023804. Epub 2011 Aug 22. PLoS One. 2011. PMID: 21887323 Free PMC article.

9

Engineered CRISPR-Cas9 nucleases with altered PAM specificities.

Kleinstiver BP, Prew MS, Tsai SQ, Topkar VV, Nguyen NT, Zheng Z, Gonzales AP, Li Z, Peterson RT, Yeh JR, Aryee MJ, Joung JK. Kleinstiver BP, et al. Nature. 2015 Jul 23;523(7561):481-5. doi: 10.1038/nature14592. Epub 2015 Jun 22. Nature. 2015. PMID: 26098369 Free PMC article.

10

Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition.

Kleinstiver BP, Prew MS, Tsai SQ, Nguyen NT, Topkar VV, Zheng Z, Joung JK. Kleinstiver BP, et al. Nat Biotechnol. 2015 Dec;33(12):1293-1298. doi: 10.1038/nbt.3404. Epub 2015 Nov 2. Nat Biotechnol. 2015. PMID: 26524662 Free PMC article.

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