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Tumour-retained activated CCR7+ dendritic cells are heterogeneous and regulate local anti-tumour cytolytic activity.
Lee CYC, Kennedy BC, Richoz N, Dean I, Tuong ZK, Gaspal F, Li Z, Willis C, Hasegawa T, Whiteside SK, Posner DA, Carlesso G, Hammond SA, Dovedi SJ, Roychoudhuri R, Withers DR, Clatworthy MR. Lee CYC, et al. Among authors: gaspal f. Nat Commun. 2024 Jan 24;15(1):682. doi: 10.1038/s41467-024-44787-1. Nat Commun. 2024. PMID: 38267413 Free PMC article.
In vivo labeling reveals continuous trafficking of TCF-1+ T cells between tumor and lymphoid tissue.
Li Z, Tuong ZK, Dean I, Willis C, Gaspal F, Fiancette R, Idris S, Kennedy B, Ferdinand JR, Peñalver A, Cabantous M, Murtuza Baker S, Fry JW, Carlesso G, Hammond SA, Dovedi SJ, Hepworth MR, Clatworthy MR, Withers DR. Li Z, et al. Among authors: gaspal f. J Exp Med. 2022 Jun 6;219(6):e20210749. doi: 10.1084/jem.20210749. Epub 2022 Apr 26. J Exp Med. 2022. PMID: 35472220 Free PMC article.
Rapid functional impairment of natural killer cells following tumor entry limits anti-tumor immunity.
Dean I, Lee CYC, Tuong ZK, Li Z, Tibbitt CA, Willis C, Gaspal F, Kennedy BC, Matei-Rascu V, Fiancette R, Nordenvall C, Lindforss U, Baker SM, Stockmann C, Sexl V, Hammond SA, Dovedi SJ, Mjösberg J, Hepworth MR, Carlesso G, Clatworthy MR, Withers DR. Dean I, et al. Among authors: gaspal f. Nat Commun. 2024 Jan 24;15(1):683. doi: 10.1038/s41467-024-44789-z. Nat Commun. 2024. PMID: 38267402 Free PMC article.
ILC3s select microbiota-specific regulatory T cells to establish tolerance in the gut.
Lyu M, Suzuki H, Kang L, Gaspal F, Zhou W, Goc J, Zhou L, Zhou J, Zhang W; JRI Live Cell Bank; Shen Z, Fox JG, Sockolow RE, Laufer TM, Fan Y, Eberl G, Withers DR, Sonnenberg GF. Lyu M, et al. Among authors: gaspal f. Nature. 2022 Oct;610(7933):744-751. doi: 10.1038/s41586-022-05141-x. Epub 2022 Sep 7. Nature. 2022. PMID: 36071169 Free PMC article.
Concurrent OX40 and CD30 Ligand Blockade Abrogates the CD4-Driven Autoimmunity Associated with CTLA4 and PD1 Blockade while Preserving Excellent Anti-CD8 Tumor Immunity.
Nawaf MG, Ulvmar MH, Withers DR, McConnell FM, Gaspal FM, Webb GJ, Jones ND, Yagita H, Allison JP, Lane PJL. Nawaf MG, et al. Among authors: gaspal fm. J Immunol. 2017 Aug 1;199(3):974-981. doi: 10.4049/jimmunol.1700088. Epub 2017 Jun 23. J Immunol. 2017. PMID: 28646041 Free PMC article.
40 results