Metzger LE 4th - Search Results

1

Gene Therapy-Mediated Partial Reprogramming Extends Lifespan and Reverses Age-Related Changes in Aged Mice.

Macip CC, Hasan R, Hoznek V, Kim J, Lu YR, Metzger LE 4th, Sethna S, Davidsohn N. Macip CC, et al. Among authors: metzger le 4th. Cell Reprogram. 2024 Feb;26(1):24-32. doi: 10.1089/cell.2023.0072. Cell Reprogram. 2024. PMID: 38381405 Free PMC article.

2

Targeted lipopolysaccharide biosynthetic intermediate analysis with normal-phase liquid chromatography mass spectrometry.

Sawyer WS, Wang L, Uehara T, Tamrakar P, Prathapam R, Mostafavi M, Metzger LE 4th, Feng B, Baxter Rath CM. Sawyer WS, et al. Among authors: metzger le 4th. PLoS One. 2019 Feb 8;14(2):e0211803. doi: 10.1371/journal.pone.0211803. eCollection 2019. PLoS One. 2019. PMID: 30735516 Free PMC article.

3

Mode of Action of the Monobactam LYS228 and Mechanisms Decreasing In Vitro Susceptibility in Escherichia coli and Klebsiella pneumoniae.

Dean CR, Barkan DT, Bermingham A, Blais J, Casey F, Casarez A, Colvin R, Fuller J, Jones AK, Li C, Lopez S, Metzger LE 4th, Mostafavi M, Prathapam R, Rasper D, Reck F, Ruzin A, Shaul J, Shen X, Simmons RL, Skewes-Cox P, Takeoka KT, Tamrakar P, Uehara T, Wei JR. Dean CR, et al. Among authors: metzger le 4th. Antimicrob Agents Chemother. 2018 Sep 24;62(10):e01200-18. doi: 10.1128/AAC.01200-18. Print 2018 Oct. Antimicrob Agents Chemother. 2018. PMID: 30061293 Free PMC article.

4

LpxK Is Essential for Growth of Acinetobacter baumannii ATCC 19606: Relationship to Toxic Accumulation of Lipid A Pathway Intermediates.

Wei JR, Richie DL, Mostafavi M, Metzger LE 4th, Rath CM, Sawyer WS, Takeoka KT, Dean CR. Wei JR, et al. Among authors: metzger le 4th. mSphere. 2017 Jul 26;2(4):e00199-17. doi: 10.1128/mSphere.00199-17. eCollection 2017 Jul-Aug. mSphere. 2017. PMID: 28815210 Free PMC article.

5

Structure-guided enzymology of the lipid A acyltransferase LpxM reveals a dual activity mechanism.

Dovala D, Rath CM, Hu Q, Sawyer WS, Shia S, Elling RA, Knapp MS, Metzger LE 4th. Dovala D, et al. Among authors: metzger le 4th. Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):E6064-E6071. doi: 10.1073/pnas.1610746113. Epub 2016 Sep 28. Proc Natl Acad Sci U S A. 2016. PMID: 27681620 Free PMC article.

6

Toxic Accumulation of LPS Pathway Intermediates Underlies the Requirement of LpxH for Growth of Acinetobacter baumannii ATCC 19606.

Richie DL, Takeoka KT, Bojkovic J, Metzger LE 4th, Rath CM, Sawyer WS, Wei JR, Dean CR. Richie DL, et al. Among authors: metzger le 4th. PLoS One. 2016 Aug 15;11(8):e0160918. doi: 10.1371/journal.pone.0160918. eCollection 2016. PLoS One. 2016. PMID: 27526195 Free PMC article.

7

Rapid analysis of protein expression and solubility with the SpyTag-SpyCatcher system.

Dovala D, Sawyer WS, Rath CM, Metzger LE 4th. Dovala D, et al. Among authors: metzger le 4th. Protein Expr Purif. 2016 Jan;117:44-51. doi: 10.1016/j.pep.2015.09.021. Epub 2015 Sep 21. Protein Expr Purif. 2016. PMID: 26405011 Free article.

8

LpxI structures reveal how a lipid A precursor is synthesized.

Metzger LE 4th, Lee JK, Finer-Moore JS, Raetz CR, Stroud RM. Metzger LE 4th, et al. Nat Struct Mol Biol. 2012 Nov;19(11):1132-8. doi: 10.1038/nsmb.2393. Epub 2012 Oct 7. Nat Struct Mol Biol. 2012. PMID: 23042606 Free PMC article.

9

An alternative route for UDP-diacylglucosamine hydrolysis in bacterial lipid A biosynthesis.

Metzger LE 4th, Raetz CR. Metzger LE 4th, et al. Biochemistry. 2010 Aug 10;49(31):6715-26. doi: 10.1021/bi1008744. Biochemistry. 2010. PMID: 20608695 Free PMC article.

10

Purification and characterization of the lipid A disaccharide synthase (LpxB) from Escherichia coli, a peripheral membrane protein.

Metzger LE 4th, Raetz CR. Metzger LE 4th, et al. Biochemistry. 2009 Dec 8;48(48):11559-71. doi: 10.1021/bi901750f. Biochemistry. 2009. PMID: 19883124 Free PMC article.

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