Sun Q - Search Results

1

Allosteric Activation of α7 Nicotinic Acetylcholine Receptors by Novel 2-Arylamino-thiazole-5-carboxylic Acid Amide Derivatives for the Improvement of Cognitive Deficits in Mice.

Yang C, Meng Y, Wang X, Li X, Yu T, Liao W, Xie W, Jiang Q, Wang H, Shi C, Jiao W, Bian X, Hu F, Wang X, Liu Y, Zhang L, Wang K, Sun Q. Yang C, et al. Among authors: sun q. J Med Chem. 2024 Apr 25;67(8):6344-6364. doi: 10.1021/acs.jmedchem.3c02323. Epub 2024 Feb 23. J Med Chem. 2024. PMID: 38393821

2

Development of novel proteasome inhibitors based on phthalazinone scaffold.

Yang L, Wang W, Sun Q, Xu F, Niu Y, Wang C, Liang L, Xu P. Yang L, et al. Among authors: sun q. Bioorg Med Chem Lett. 2016 Jun 15;26(12):2801-2805. doi: 10.1016/j.bmcl.2016.04.067. Epub 2016 Apr 23. Bioorg Med Chem Lett. 2016. PMID: 27158142

3

Synthesis and evaluation of 1-phenyl-1H-1,2,3-triazole-4-carboxylic acid derivatives as xanthine oxidase inhibitors.

Zhang TJ, Wu QX, Li SY, Wang L, Sun Q, Zhang Y, Meng FH, Gao H. Zhang TJ, et al. Among authors: sun q. Bioorg Med Chem Lett. 2017 Aug 15;27(16):3812-3816. doi: 10.1016/j.bmcl.2017.06.059. Epub 2017 Jun 23. Bioorg Med Chem Lett. 2017. PMID: 28693909

4

The current agonists and positive allosteric modulators of α7 nAChR for CNS indications in clinical trials.

Yang T, Xiao T, Sun Q, Wang K. Yang T, et al. Among authors: sun q. Acta Pharm Sin B. 2017 Nov;7(6):611-622. doi: 10.1016/j.apsb.2017.09.001. Epub 2017 Oct 16. Acta Pharm Sin B. 2017. PMID: 29159020 Free PMC article. Review.

5

Design and Synthesis of Novel Positive Allosteric Modulators of α7 Nicotinic Acetylcholine Receptors with the Ability To Rescue Auditory Gating Deficit in Mice.

Li Y, Sun L, Yang T, Jiao W, Tang J, Huang X, Huang Z, Meng Y, Luo L, Wang X, Bian X, Zhang F, Wang K, Sun Q. Li Y, et al. Among authors: sun l, sun q. J Med Chem. 2019 Jan 10;62(1):159-173. doi: 10.1021/acs.jmedchem.7b01492. Epub 2018 Apr 9. J Med Chem. 2019. PMID: 29587480

6

Pharmacological characterization of JWX-A0108 as a novel type I positive allosteric modulator of α7 nAChR that can reverse acoustic gating deficits in a mouse prepulse inhibition model.

Sun LL, Yang TY, Wei NN, Lu W, Jiao WX, Zhou QQ, Miao YZ, Gao Q, Wang XT, Sun Q, Wang K. Sun LL, et al. Among authors: sun q. Acta Pharmacol Sin. 2019 Jun;40(6):737-745. doi: 10.1038/s41401-018-0163-y. Epub 2018 Oct 17. Acta Pharmacol Sin. 2019. PMID: 30333556 Free PMC article.

7

Chemical conversion of nicotinamide into type I positive allosteric modulator of α7 nAChRs.

Li X, Xie W, Wang X, Huang Z, Bian X, Wang K, Sun Q. Li X, et al. Among authors: sun q. Bioorg Med Chem Lett. 2019 Aug 1;29(15):1928-1933. doi: 10.1016/j.bmcl.2019.05.046. Epub 2019 May 22. Bioorg Med Chem Lett. 2019. PMID: 31153804

8

Synthesis and Biological Evaluation of Novel Triazine Derivatives as Positive Allosteric Modulators of α7 Nicotinic Acetylcholine Receptors.

Wang X, Xiao H, Wang J, Huang Z, Peng G, Xie W, Bian X, Liu H, Shi C, Yang T, Li X, Gao J, Meng Y, Jiang Q, Chen W, Hu F, Wei N, Wang X, Zhang L, Wang K, Sun Q. Wang X, et al. Among authors: sun q. J Med Chem. 2021 Aug 26;64(16):12379-12396. doi: 10.1021/acs.jmedchem.1c01058. Epub 2021 Aug 10. J Med Chem. 2021. PMID: 34374537

9

Discovery of 2-(furan-2-ylmethylene)hydrazine-1-carbothioamide derivatives as novel inhibitors of SARS-CoV-2 main protease.

Dou X, Sun Q, Xu G, Liu Y, Zhang C, Wang B, Lu Y, Guo Z, Su L, Huo T, Zhao X, Wang C, Yu Z, Song S, Zhang L, Liu Z, Lai L, Jiao N. Dou X, et al. Among authors: sun q. Eur J Med Chem. 2022 Aug 5;238:114508. doi: 10.1016/j.ejmech.2022.114508. Epub 2022 Jun 3. Eur J Med Chem. 2022. PMID: 35688005 Free PMC article.

10

1,4-Disubstituted Piperazin-2-Ones as Selective Late Sodium Current Inhibitors with QT Interval Shortening Properties in Isolated Rabbit Hearts.

Yang H, Jing M, Tian C, Li B, Liao W, Wang W, Li Y, Wang X, Duan G, Sun Q, Huang Z, Wu L. Yang H, et al. Among authors: sun q. J Med Chem. 2024 Aug 8;67(15):12676-12694. doi: 10.1021/acs.jmedchem.4c00677. Epub 2024 May 17. J Med Chem. 2024. PMID: 38757601

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