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134,369 results

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An Antiherpesviral Host-Directed Strategy Based on CDK7 Covalently Binding Drugs: Target-Selective, Picomolar-Dose, Cross-Virus Reactivity.
Yu D, Wagner S, Schütz M, Jeon Y, Seo M, Kim J, Brückner N, Kicuntod J, Tillmanns J, Wangen C, Hahn F, Kaufer BB, Neipel F, Eickhoff J, Klebl B, Nam K, Marschall M. Yu D, et al. Among authors: kim j. Pharmaceutics. 2024 Jan 23;16(2):158. doi: 10.3390/pharmaceutics16020158. Pharmaceutics. 2024. PMID: 38399219 Free PMC article.
Safety, Tolerability, Pharmacokinetics, and Metabolism of Telacebec (Q203) for the Treatment of Tuberculosis: a Randomized, Placebo-Controlled, Multiple Ascending Dose Phase 1B Trial.
Kim J, Choi J, Kang H, Ahn J, Hutchings J, Niekerk CV, Kim J, Jeon Y, Nam K, Kim TH, Shin BS, Shin S. Kim J, et al. Among authors: kim th. Antimicrob Agents Chemother. 2023 Jan 24;67(1):e0112322. doi: 10.1128/aac.01123-22. Epub 2022 Dec 12. Antimicrob Agents Chemother. 2023. PMID: 36507677 Free PMC article. Clinical Trial.
Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis.
Pethe K, Bifani P, Jang J, Kang S, Park S, Ahn S, Jiricek J, Jung J, Jeon HK, Cechetto J, Christophe T, Lee H, Kempf M, Jackson M, Lenaerts AJ, Pham H, Jones V, Seo MJ, Kim YM, Seo M, Seo JJ, Park D, Ko Y, Choi I, Kim R, Kim SY, Lim S, Yim SA, Nam J, Kang H, Kwon H, Oh CT, Cho Y, Jang Y, Kim J, Chua A, Tan BH, Nanjundappa MB, Rao SP, Barnes WS, Wintjens R, Walker JR, Alonso S, Lee S, Kim J, Oh S, Oh T, Nehrbass U, Han SJ, No Z, Lee J, Brodin P, Cho SN, Nam K, Kim J. Pethe K, et al. Among authors: kim r, kim ym, kim sy, kim j. Nat Med. 2013 Sep;19(9):1157-60. doi: 10.1038/nm.3262. Epub 2013 Aug 4. Nat Med. 2013. PMID: 23913123 Free article.
Lead optimization of a novel series of imidazo[1,2-a]pyridine amides leading to a clinical candidate (Q203) as a multi- and extensively-drug-resistant anti-tuberculosis agent.
Kang S, Kim RY, Seo MJ, Lee S, Kim YM, Seo M, Seo JJ, Ko Y, Choi I, Jang J, Nam J, Park S, Kang H, Kim HJ, Kim J, Ahn S, Pethe K, Nam K, No Z, Kim J. Kang S, et al. Among authors: kim hj, kim ym, kim ry, kim j. J Med Chem. 2014 Jun 26;57(12):5293-305. doi: 10.1021/jm5003606. Epub 2014 Jun 17. J Med Chem. 2014. PMID: 24870926
Discovery of thienothiazolocarboxamide analogues as novel anti-tubercular agent.
Jin G, Mi Kim Y, Lee A, Choi J, Kang S, Seo M, Jea Seo J, Lee S, Kang J, Kim J, Park S, Woo M, Falcão VCA, Lee H, Heo J, Shum D, Park K, Delorme V, Choi I. Jin G, et al. Among authors: kim j. Bioorg Med Chem. 2020 Dec 1;28(23):115797. doi: 10.1016/j.bmc.2020.115797. Epub 2020 Oct 3. Bioorg Med Chem. 2020. PMID: 33075682
High content screening identifies decaprenyl-phosphoribose 2' epimerase as a target for intracellular antimycobacterial inhibitors.
Christophe T, Jackson M, Jeon HK, Fenistein D, Contreras-Dominguez M, Kim J, Genovesio A, Carralot JP, Ewann F, Kim EH, Lee SY, Kang S, Seo MJ, Park EJ, Skovierová H, Pham H, Riccardi G, Nam JY, Marsollier L, Kempf M, Joly-Guillou ML, Oh T, Shin WK, No Z, Nehrbass U, Brosch R, Cole ST, Brodin P. Christophe T, et al. Among authors: kim eh, kim j. PLoS Pathog. 2009 Oct;5(10):e1000645. doi: 10.1371/journal.ppat.1000645. Epub 2009 Oct 30. PLoS Pathog. 2009. PMID: 19876393 Free PMC article.
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