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73 results

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Enhanced T cell receptor specificity through framework engineering.
Rosenberg AM, Ayres CM, Medina-Cucurella AV, Whitehead TA, Baker BM. Rosenberg AM, et al. Among authors: whitehead ta. Front Immunol. 2024 Mar 12;15:1345368. doi: 10.3389/fimmu.2024.1345368. eCollection 2024. Front Immunol. 2024. PMID: 38545094 Free PMC article.
An orthogonalized PYR1-based CID module with reprogrammable ligand-binding specificity.
Park SY, Qiu J, Wei S, Peterson FC, Beltrán J, Medina-Cucurella AV, Vaidya AS, Xing Z, Volkman BF, Nusinow DA, Whitehead TA, Wheeldon I, Cutler SR. Park SY, et al. Among authors: whitehead ta. Nat Chem Biol. 2024 Jan;20(1):103-110. doi: 10.1038/s41589-023-01447-7. Epub 2023 Oct 23. Nat Chem Biol. 2024. PMID: 37872402 Free PMC article.
GMMA Can Stabilize Proteins Across Different Functional Constraints.
Daffern N, Johansson KE, Baumer ZT, Robertson NR, Woojuh J, Bedewitz MA, Davis Z, Wheeldon I, Cutler SR, Lindorff-Larsen K, Whitehead TA. Daffern N, et al. Among authors: whitehead ta. J Mol Biol. 2024 Jun 1;436(11):168586. doi: 10.1016/j.jmb.2024.168586. Epub 2024 Apr 23. J Mol Biol. 2024. PMID: 38663544
Rationalizing diverse binding mechanisms to the same protein fold: insights for ligand recognition and biosensor design.
Leonard AC, Friedman AJ, Chayer R, Petersen BM, Kaar J, Shirts MR, Whitehead TA. Leonard AC, et al. Among authors: whitehead ta. bioRxiv [Preprint]. 2024 Mar 29:2024.03.25.586677. doi: 10.1101/2024.03.25.586677. bioRxiv. 2024. Update in: ACS Chem Biol. 2024 Aug 16;19(8):1757-1772. doi: 10.1021/acschembio.4c00243. PMID: 38586024 Free PMC article. Updated. Preprint.
An integrated technology for quantitative wide mutational scanning of human antibody Fab libraries.
Petersen BM, Kirby MB, Chrispens KM, Irvin OM, Strawn IK, Haas CM, Walker AM, Baumer ZT, Ulmer SA, Ayala E, Rhodes ER, Guthmiller JJ, Steiner PJ, Whitehead TA. Petersen BM, et al. Among authors: whitehead ta. bioRxiv [Preprint]. 2024 Jan 16:2024.01.16.575852. doi: 10.1101/2024.01.16.575852. bioRxiv. 2024. Update in: Nat Commun. 2024 May 10;15(1):3974. doi: 10.1038/s41467-024-48072-z. PMID: 38293170 Free PMC article. Updated. Preprint.
Deep screening of antibody-antigen affinities.
Whitehead TA. Whitehead TA. Nat Biomed Eng. 2024 Mar;8(3):203-204. doi: 10.1038/s41551-023-01169-0. Nat Biomed Eng. 2024. PMID: 38151637 No abstract available.
73 results