Abdel-Aziz HA - Search Results

1

Discovery of novel quinolin-2-one derivatives as potential GSK-3β inhibitors for treatment of Alzheimer's disease: Pharmacophore-based design, preliminary SAR, in vitro and in vivo biological evaluation.

Abdo Moustafa E, Abdelrasheed Allam H, Fouad MA, El Kerdawy AM, Nasser Eid El-Sayed N, Wagner C, Abdel-Aziz HA, Abdel Fattah Ezzat M. Abdo Moustafa E, et al. Bioorg Chem. 2024 May;146:107324. doi: 10.1016/j.bioorg.2024.107324. Epub 2024 Mar 30. Bioorg Chem. 2024. PMID: 38569322

2

Fragment merging approach for the design of thiazole/thiazolidine clubbed pyrazoline derivatives as anti-inflammatory agents: Synthesis, biopharmacological evaluation and molecular modeling studies.

Elgohary MK, Abd El Hadi SR, Abo-Ashour MF, Abo-El Fetoh ME, Afify H, Abdel-Aziz HA, Abou-Seri SM. Elgohary MK, et al. Bioorg Chem. 2023 Oct;139:106724. doi: 10.1016/j.bioorg.2023.106724. Epub 2023 Jul 8. Bioorg Chem. 2023. PMID: 37451146

3

Fenamates and ibuprofen as foundational components in the synthesis of innovative, targeted COX-2 anti-inflammatory drugs, undergoing thorough biopharmacological assessments and in-silico computational studies.

Elgohary MK, Elkotamy MS, Abdelrahman Alkabbani M, Abdel-Aziz HA. Elgohary MK, et al. Bioorg Chem. 2024 Jun;147:107393. doi: 10.1016/j.bioorg.2024.107393. Epub 2024 Apr 24. Bioorg Chem. 2024. PMID: 38691908

4

Unveiling the potential of isatin-grafted phenyl-1,2,3-triazole derivatives as dual VEGFR-2/STAT-3 inhibitors: Design, synthesis and biological assessments.

Elsebaie HA, Abdulla MH, Elsayed ZM, Shaldam MA, Tawfik HO, Morsy SN, Vaali Mohammed MA, Bin Traiki T, Elkaeed EB, Abdel-Aziz HA, Eldehna WM. Elsebaie HA, et al. Bioorg Chem. 2024 Oct;151:107626. doi: 10.1016/j.bioorg.2024.107626. Epub 2024 Jul 10. Bioorg Chem. 2024. PMID: 39013242

5

Novel imidazo[2,1-b]thiazoles and imidazo[1,2-a]pyridines tethered with indolinone motif as VEGFR-2 inhibitors and apoptotic inducers: Design, synthesis and biological evaluations.

Elkotamy MS, Elgohary MK, Al-Rashood ST, Almahli H, Eldehna WM, Abdel-Aziz HA. Elkotamy MS, et al. Bioorg Chem. 2024 Oct;151:107644. doi: 10.1016/j.bioorg.2024.107644. Epub 2024 Jul 15. Bioorg Chem. 2024. PMID: 39079394

6

Novel anti-inflammatory agents featuring phenoxy acetic acid moiety as a pharmacophore for selective COX-2 inhibitors: Synthesis, biological evaluation, histopathological examination and molecular modeling investigation.

Elgohary MK, Abo-Ashour MF, Abd El Hadi SR, El Hassab MA, Abo-El Fetoh ME, Afify H, Abdel-Aziz HA, Abou-Seri SM. Elgohary MK, et al. Among authors: abdel aziz ha. Bioorg Chem. 2024 Nov;152:107727. doi: 10.1016/j.bioorg.2024.107727. Epub 2024 Aug 15. Bioorg Chem. 2024. PMID: 39167872

7

Mitigating the resistance of MCF-7 cancer cells to Doxorubicin under hypoxic conditions with novel coumarin based carbonic anhydrase IX and XII inhibitors.

Abdelaal HI, Mohamed AR, Abo-Ashour MF, Giovannuzzi S, Fahim SH, Abdel-Aziz HA, Supuran CT, Abou-Seri SM. Abdelaal HI, et al. Among authors: abdel aziz ha. Bioorg Chem. 2024 Nov;152:107759. doi: 10.1016/j.bioorg.2024.107759. Epub 2024 Aug 26. Bioorg Chem. 2024. PMID: 39213797

8

Development of new LSM-83177 analogues as anti-tumor agents against colorectal cancer targeting p53-MDM2 interaction.

Elgohary MK, Elkotamy MS, Al-Warhi T, Eldehna WM, Abdel-Aziz HA. Elgohary MK, et al. Among authors: abdel aziz ha. Bioorg Chem. 2024 Aug 28;153:107766. doi: 10.1016/j.bioorg.2024.107766. Online ahead of print. Bioorg Chem. 2024. PMID: 39244969

9

Unveiling the anticancer potential of novel spirooxindole-tethered pyrazolopyridine derivatives.

Eldehna WM, Abdulla MH, Nafie MS, Elsawi AE, Ayman S, Shahin MI, Alhassan NS, Zubaidi AM, Ghabbour HA, Elaasser M, Al-Karmalawy AA, Abdel-Aziz HA. Eldehna WM, et al. Among authors: abdel aziz ha. Bioorg Chem. 2024 Aug 31;153:107778. doi: 10.1016/j.bioorg.2024.107778. Online ahead of print. Bioorg Chem. 2024. PMID: 39244971

10

Identification of indole-grafted pyrazolopyrimidine and pyrazolopyridine derivatives as new anti-cancer agents: Synthesis, biological assessments, and molecular modeling insights.

Eldehna WM, Tawfik HO, Abdulla MH, Nafie MS, Aref H, Shaldam MA, Alhassan NS, Al Obeed O, Elsayed ZM, Abdel-Aziz HA. Eldehna WM, et al. Among authors: abdel aziz ha. Bioorg Chem. 2024 Sep 6;153:107804. doi: 10.1016/j.bioorg.2024.107804. Online ahead of print. Bioorg Chem. 2024. PMID: 39276491

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