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Structure-guided SCHEMA recombination generates diverse chimeric channelrhodopsins.
Bedbrook CN, Rice AJ, Yang KK, Ding X, Chen S, LeProust EM, Gradinaru V, Arnold FH. Bedbrook CN, et al. Among authors: gradinaru v. Proc Natl Acad Sci U S A. 2017 Mar 28;114(13):E2624-E2633. doi: 10.1073/pnas.1700269114. Epub 2017 Mar 10. Proc Natl Acad Sci U S A. 2017. PMID: 28283661 Free PMC article.
Positron emission tomography imaging of novel AAV capsids maps rapid brain accumulation.
Seo JW, Ingham ES, Mahakian L, Tumbale S, Wu B, Aghevlian S, Shams S, Baikoghli M, Jain P, Ding X, Goeden N, Dobreva T, Flytzanis NC, Chavez M, Singhal K, Leib R, James ML, Segal DJ, Cheng RH, Silva EA, Gradinaru V, Ferrara KW. Seo JW, et al. Among authors: gradinaru v. Nat Commun. 2020 Apr 30;11(1):2102. doi: 10.1038/s41467-020-15818-4. Nat Commun. 2020. PMID: 32355221 Free PMC article.
Negative feedback control of neuronal activity by microglia.
Badimon A, Strasburger HJ, Ayata P, Chen X, Nair A, Ikegami A, Hwang P, Chan AT, Graves SM, Uweru JO, Ledderose C, Kutlu MG, Wheeler MA, Kahan A, Ishikawa M, Wang YC, Loh YE, Jiang JX, Surmeier DJ, Robson SC, Junger WG, Sebra R, Calipari ES, Kenny PJ, Eyo UB, Colonna M, Quintana FJ, Wake H, Gradinaru V, Schaefer A. Badimon A, et al. Among authors: gradinaru v. Nature. 2020 Oct;586(7829):417-423. doi: 10.1038/s41586-020-2777-8. Epub 2020 Sep 30. Nature. 2020. PMID: 32999463 Free PMC article.
Adeno-Associated Virus Toolkit to Target Diverse Brain Cells.
Challis RC, Ravindra Kumar S, Chen X, Goertsen D, Coughlin GM, Hori AM, Chuapoco MR, Otis TS, Miles TF, Gradinaru V. Challis RC, et al. Among authors: gradinaru v. Annu Rev Neurosci. 2022 Jul 8;45:447-469. doi: 10.1146/annurev-neuro-111020-100834. Epub 2022 Apr 19. Annu Rev Neurosci. 2022. PMID: 35440143 Free article. Review.
Engineered AAVs for non-invasive gene delivery to rodent and non-human primate nervous systems.
Chen X, Ravindra Kumar S, Adams CD, Yang D, Wang T, Wolfe DA, Arokiaraj CM, Ngo V, Campos LJ, Griffiths JA, Ichiki T, Mazmanian SK, Osborne PB, Keast JR, Miller CT, Fox AS, Chiu IM, Gradinaru V. Chen X, et al. Among authors: gradinaru v. Neuron. 2022 Jul 20;110(14):2242-2257.e6. doi: 10.1016/j.neuron.2022.05.003. Epub 2022 May 27. Neuron. 2022. PMID: 35643078 Free PMC article.
Structural basis of receptor usage by the engineered capsid AAV-PHP.eB.
Jang S, Shen HK, Ding X, Miles TF, Gradinaru V. Jang S, et al. Among authors: gradinaru v. Mol Ther Methods Clin Dev. 2022 Jul 31;26:343-354. doi: 10.1016/j.omtm.2022.07.011. eCollection 2022 Sep 8. Mol Ther Methods Clin Dev. 2022. PMID: 36034770 Free PMC article.
169 results