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911 results

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Page 1
Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers.
Diepstraten ST, Yuan Y, La Marca JE, Young S, Chang C, Whelan L, Ross AM, Fischer KC, Pomilio G, Morris R, Georgiou A, Litalien V, Brown FC, Roberts AW, Strasser A, Wei AH, Kelly GL. Diepstraten ST, et al. Among authors: strasser a. Cancer Cell. 2024 May 13;42(5):850-868.e9. doi: 10.1016/j.ccell.2024.04.004. Epub 2024 Apr 25. Cancer Cell. 2024. PMID: 38670091 Free article.
Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic.
Kuroda J, Puthalakath H, Cragg MS, Kelly PN, Bouillet P, Huang DC, Kimura S, Ottmann OG, Druker BJ, Villunger A, Roberts AW, Strasser A. Kuroda J, et al. Among authors: strasser a. Proc Natl Acad Sci U S A. 2006 Oct 3;103(40):14907-12. doi: 10.1073/pnas.0606176103. Epub 2006 Sep 22. Proc Natl Acad Sci U S A. 2006. PMID: 16997913 Free PMC article.
ER stress triggers apoptosis by activating BH3-only protein Bim.
Puthalakath H, O'Reilly LA, Gunn P, Lee L, Kelly PN, Huntington ND, Hughes PD, Michalak EM, McKimm-Breschkin J, Motoyama N, Gotoh T, Akira S, Bouillet P, Strasser A. Puthalakath H, et al. Among authors: strasser a. Cell. 2007 Jun 29;129(7):1337-49. doi: 10.1016/j.cell.2007.04.027. Cell. 2007. PMID: 17604722 Free article.
The essential role of evasion from cell death in cancer.
Kelly GL, Strasser A. Kelly GL, et al. Among authors: strasser a. Adv Cancer Res. 2011;111:39-96. doi: 10.1016/B978-0-12-385524-4.00002-7. Adv Cancer Res. 2011. PMID: 21704830 Free PMC article. Review.
The detection of genetic lesions in human cancers that activate prosurvival genes or disable proapoptotic genes have provided the first evidence that defects in programmed cell death can cause cancer (Tagawa et al., 2005; Tsujimoto et al., 1984; Vaux, Cory, and Adams, 1988) and t …
The detection of genetic lesions in human cancers that activate prosurvival genes or disable proapoptotic genes have provided the first evid …
Fas-mediated neutrophil apoptosis is accelerated by Bid, Bak, and Bax and inhibited by Bcl-2 and Mcl-1.
Croker BA, O'Donnell JA, Nowell CJ, Metcalf D, Dewson G, Campbell KJ, Rogers KL, Hu Y, Smyth GK, Zhang JG, White M, Lackovic K, Cengia LH, O'Reilly LA, Bouillet P, Cory S, Strasser A, Roberts AW. Croker BA, et al. Among authors: strasser a. Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13135-40. doi: 10.1073/pnas.1110358108. Epub 2011 Jul 18. Proc Natl Acad Sci U S A. 2011. PMID: 21768356 Free PMC article.
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