Jiang XQ - Search Results

1

Novel Isoalantolactone-Based Derivatives as Potent NLRP3 Inflammasome Inhibitors: Design, Synthesis, and Biological Characterization.

Zhao M, Ye N, Liu L, Zhang RJ, Li N, Peng J, Cai XY, Jiang XQ, Su KY, Zhang XL, Rao QR, Liu KJ, Deng DX, Peng AH, Tang MH, Chen LJ, Wu WS, Ye HY. Zhao M, et al. Among authors: jiang xq. J Med Chem. 2024 May 9;67(9):7516-7538. doi: 10.1021/acs.jmedchem.4c00357. Epub 2024 Apr 30. J Med Chem. 2024. PMID: 38686671

2

New Highly Potent NLRP3 Inhibitors: Furanochalcone Velutone F Analogues.

Zhang R, Hong F, Zhao M, Cai X, Jiang X, Ye N, Su K, Li N, Tang M, Ma X, Ni H, Wang L, Wan L, Chen L, Wu W, Ye H. Zhang R, et al. ACS Med Chem Lett. 2022 Mar 7;13(4):560-569. doi: 10.1021/acsmedchemlett.1c00597. eCollection 2022 Apr 14. ACS Med Chem Lett. 2022. PMID: 35450356 Free PMC article.

3

Identification of the target protein and molecular mechanism of honokiol in anti-inflammatory action.

Cai X, Jiang X, Zhao M, Su K, Tang M, Hong F, Ye N, Zhang R, Li N, Wang L, Xue L, Zhu Z, Chen L, Yang J, Wu W, Ye H. Cai X, et al. Phytomedicine. 2023 Jan;109:154617. doi: 10.1016/j.phymed.2022.154617. Epub 2022 Dec 19. Phytomedicine. 2023. PMID: 36610140

4

From lead to clinic: A review of the structural design of P2X7R antagonists.

Zhang R, Li N, Zhao M, Tang M, Jiang X, Cai X, Ye N, Su K, Peng J, Zhang X, Wu W, Ye H. Zhang R, et al. Eur J Med Chem. 2023 May 5;251:115234. doi: 10.1016/j.ejmech.2023.115234. Epub 2023 Mar 3. Eur J Med Chem. 2023. PMID: 36893624 Review.

5

Design, Synthesis, and Biological Evaluation of Novel P2X7 Receptor Antagonists for the Treatment of Septic Acute Kidney Injury.

Zhang R, Su K, Yang L, Tang M, Zhao M, Ye N, Cai X, Jiang X, Li N, Peng J, Zhang X, Wang B, Wu W, Ma L, Ye H. Zhang R, et al. J Med Chem. 2023 Aug 24;66(16):11365-11389. doi: 10.1021/acs.jmedchem.3c00837. Epub 2023 Aug 15. J Med Chem. 2023. PMID: 37582195

6

Discovery of Triazinone Derivatives as Novel, Specific, and Direct NLRP3 Inflammasome Inhibitors for the Treatment of DSS-Induced Ulcerative Colitis.

Li N, Jiang X, Zhang R, Ye N, Tang M, Cai X, Su K, Peng J, Zhang X, Zhao M, Wu W, Ye H. Li N, et al. J Med Chem. 2023 Oct 12;66(19):13428-13451. doi: 10.1021/acs.jmedchem.3c00696. Epub 2023 Sep 27. J Med Chem. 2023. PMID: 37756547

7

Recent Progress and Prospects of Small Molecules for NLRP3 Inflammasome Inhibition.

Li N, Zhang R, Tang M, Zhao M, Jiang X, Cai X, Ye N, Su K, Peng J, Zhang X, Wu W, Ye H. Li N, et al. J Med Chem. 2023 Nov 9;66(21):14447-14473. doi: 10.1021/acs.jmedchem.3c01370. Epub 2023 Oct 25. J Med Chem. 2023. PMID: 37879043 Review.

8

Exploring the Immunomodulatory Properties of Red Onion (Allium cepa L.) Skin: Isolation, Structural Elucidation, and Bioactivity Study of Novel Onion Chalcones Targeting the A_2A Adenosine Receptor.

Zhang RJ, Rao QR, Jiang XQ, Ye N, Li N, Du HL, Zhang SJ, Ye HY, Wu WS, Zhao M. Zhang RJ, et al. Among authors: jiang xq. J Agric Food Chem. 2023 Nov 6. doi: 10.1021/acs.jafc.3c03851. Online ahead of print. J Agric Food Chem. 2023. PMID: 37931326

9

NU6300 covalently reacts with cysteine-191 of gasdermin D to block its cleavage and palmitoylation.

Jiang X, Zhang X, Cai X, Li N, Zheng H, Tang M, Zhu J, Su K, Zhang R, Ye N, Peng J, Zhao M, Wu W, Yang J, Ye H. Jiang X, et al. Sci Adv. 2024 Feb 9;10(6):eadi9284. doi: 10.1126/sciadv.adi9284. Epub 2024 Feb 7. Sci Adv. 2024. PMID: 38324683 Free PMC article.

10

Discovery of a Potent, Orally Active, and Long-Lasting P2X7 Receptor Antagonist as a Preclinical Candidate for Delaying the Progression of Chronic Kidney Disease.

Zhang R, Su K, Yang L, Duan H, Tang L, Tang M, Zhao M, Ye N, Cai X, Jiang X, Li N, Peng J, Zhang X, Tang L, Qiu Q, Chen L, Wu W, Hu J, Ma L, Ye H. Zhang R, et al. J Med Chem. 2024 Oct 10;67(19):17472-17496. doi: 10.1021/acs.jmedchem.4c01395. Epub 2024 Sep 23. J Med Chem. 2024. PMID: 39311818

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