Sprague DJ - Search Results

1

Target-based discovery of a broad-spectrum flukicide.

Sprague DJ, Park SK, Gramberg S, Bauer L, Rohr CM, Chulkov EG, Smith E, Scampavia L, Spicer TP, Haeberlein S, Marchant JS. Sprague DJ, et al. Nat Struct Mol Biol. 2024 Sep;31(9):1386-1393. doi: 10.1038/s41594-024-01298-3. Epub 2024 May 7. Nat Struct Mol Biol. 2024. PMID: 38714890

2

Target-based discovery of a broad spectrum flukicide.

Sprague DJ, Park SK, Gramberg S, Bauer L, Rohr CM, Chulkov EG, Smith E, Scampavia L, Spicer TP, Haeberlein S, Marchant JS. Sprague DJ, et al. bioRxiv [Preprint]. 2023 Sep 22:2023.09.22.559026. doi: 10.1101/2023.09.22.559026. bioRxiv. 2023. Update in: Nat Struct Mol Biol. 2024 Sep;31(9):1386-1393. doi: 10.1038/s41594-024-01298-3. PMID: 37790347 Free PMC article. Updated. Preprint.

3

Natural variation in the binding pocket of a parasitic flatworm TRPM channel resolves the basis for praziquantel sensitivity.

Rohr CM, Sprague DJ, Park SK, Malcolm NJ, Marchant JS. Rohr CM, et al. Among authors: sprague dj. Proc Natl Acad Sci U S A. 2023 Jan 3;120(1):e2217732120. doi: 10.1073/pnas.2217732120. Epub 2022 Dec 27. Proc Natl Acad Sci U S A. 2023. PMID: 36574686 Free PMC article.

4

The Anthelmintic Activity of Praziquantel Analogs Correlates with Structure-Activity Relationships at TRPM_PZQ Orthologs.

Sprague DJ, Kaethner M, Park SK, Rohr CM, Harris JL, Maillard D, Spangenberg T, Lundström-Stadelmann B, Marchant JS. Sprague DJ, et al. ACS Med Chem Lett. 2023 Oct 25;14(11):1537-1543. doi: 10.1021/acsmedchemlett.3c00350. eCollection 2023 Nov 9. ACS Med Chem Lett. 2023. PMID: 37970586 Free PMC article.

5

The anthelmintic meclonazepam activates a schistosome transient receptor potential channel.

Park SK, Sprague DJ, Rohr CM, Chulkov EG, Petrow I, Kumar S, Marchant JS. Park SK, et al. Among authors: sprague dj. J Biol Chem. 2024 Jan;300(1):105528. doi: 10.1016/j.jbc.2023.105528. Epub 2023 Dec 1. J Biol Chem. 2024. PMID: 38043794 Free PMC article.

6

Molecular and cellular basis of praziquantel action in the cardiovascular system.

Yahya NA, Lanham JK, Sprague DJ, Palygin O, McCorvy JD, Marchant JS. Yahya NA, et al. Among authors: sprague dj. Am J Physiol Cell Physiol. 2023 Feb 1;324(2):C573-C587. doi: 10.1152/ajpcell.00520.2022. Epub 2023 Jan 9. Am J Physiol Cell Physiol. 2023. PMID: 36622066 Free PMC article.

7

Zinc-chelating BET bromodomain inhibitors equally target islet endocrine cell types.

Jones Lipinski RA, Stancill JS, Nuñez R, Wynia-Smith SL, Sprague DJ, Nord JA, Bird A, Corbett JA, Smith BC. Jones Lipinski RA, et al. Among authors: sprague dj. Am J Physiol Regul Integr Comp Physiol. 2024 Jun 1;326(6):R515-R527. doi: 10.1152/ajpregu.00259.2023. Epub 2024 Apr 15. Am J Physiol Regul Integr Comp Physiol. 2024. PMID: 38618911

8

Fluorinated triphenylphosphonium analogs improve cell selectivity and in vivo detection of mito-metformin.

AbuEid M, Keyes RF, McAllister D, Peterson F, Kadamberi IP, Sprague DJ, Chaluvally-Raghavan P, Smith BC, Dwinell MB. AbuEid M, et al. Among authors: sprague dj. iScience. 2022 Nov 26;25(12):105670. doi: 10.1016/j.isci.2022.105670. eCollection 2022 Dec 22. iScience. 2022. PMID: 36567718 Free PMC article.

9

Mu-opioid receptor selective superagonists produce prolonged respiratory depression.

Malcolm NJ, Palkovic B, Sprague DJ, Calkins MM, Lanham JK, Halberstadt AL, Stucke AG, McCorvy JD. Malcolm NJ, et al. Among authors: sprague dj. iScience. 2023 Jun 13;26(7):107121. doi: 10.1016/j.isci.2023.107121. eCollection 2023 Jul 21. iScience. 2023. PMID: 37416459 Free PMC article.

10

The TRIM33 Bromodomain Recognizes Histone Lysine Lactylation.

Nuñez R, Sidlowski PFW, Steen EA, Wynia-Smith SL, Sprague DJ, Keyes RF, Smith BC. Nuñez R, et al. Among authors: sprague dj. ACS Chem Biol. 2024 Nov 18. doi: 10.1021/acschembio.4c00248. Online ahead of print. ACS Chem Biol. 2024. PMID: 39556662

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