Mitchell DA - Search Results

1

Darobactin Substrate Engineering and Computation Show Radical Stability Governs Ether versus C-C Bond Formation.

Woodard AM, Peccati F, Navo CD, Jiménez-Osés G, Mitchell DA. Woodard AM, et al. Among authors: mitchell da. J Am Chem Soc. 2024 May 22;146(20):14328-14340. doi: 10.1021/jacs.4c03994. Epub 2024 May 10. J Am Chem Soc. 2024. PMID: 38728535 Free PMC article.

2

Insights into the mechanism of peptide cyclodehydrations achieved through the chemoenzymatic generation of amide derivatives.

Dunbar KL, Mitchell DA. Dunbar KL, et al. Among authors: mitchell da. J Am Chem Soc. 2013 Jun 12;135(23):8692-701. doi: 10.1021/ja4029507. Epub 2013 May 30. J Am Chem Soc. 2013. PMID: 23721104 Free PMC article.

3

Identification of an Auxiliary Leader Peptide-Binding Protein Required for Azoline Formation in Ribosomal Natural Products.

Dunbar KL, Tietz JI, Cox CL, Burkhart BJ, Mitchell DA. Dunbar KL, et al. Among authors: mitchell da. J Am Chem Soc. 2015 Jun 24;137(24):7672-7. doi: 10.1021/jacs.5b04682. Epub 2015 Jun 12. J Am Chem Soc. 2015. PMID: 26024319 Free PMC article.

4

In Vitro Biosynthesis of the Core Scaffold of the Thiopeptide Thiomuracin.

Hudson GA, Zhang Z, Tietz JI, Mitchell DA, van der Donk WA. Hudson GA, et al. Among authors: mitchell da. J Am Chem Soc. 2015 Dec 30;137(51):16012-5. doi: 10.1021/jacs.5b10194. Epub 2015 Dec 21. J Am Chem Soc. 2015. PMID: 26675417 Free PMC article.

5

Biosynthetic Timing and Substrate Specificity for the Thiopeptide Thiomuracin.

Zhang Z, Hudson GA, Mahanta N, Tietz JI, van der Donk WA, Mitchell DA. Zhang Z, et al. Among authors: mitchell da. J Am Chem Soc. 2016 Dec 7;138(48):15511-15514. doi: 10.1021/jacs.6b08987. Epub 2016 Oct 13. J Am Chem Soc. 2016. PMID: 27700071 Free PMC article.

6

Targeting Reactive Carbonyls for Identifying Natural Products and Their Biosynthetic Origins.

Maxson T, Tietz JI, Hudson GA, Guo XR, Tai HC, Mitchell DA. Maxson T, et al. Among authors: mitchell da. J Am Chem Soc. 2016 Nov 23;138(46):15157-15166. doi: 10.1021/jacs.6b06848. Epub 2016 Nov 14. J Am Chem Soc. 2016. PMID: 27797509 Free PMC article.

7

Reconstitution and Substrate Specificity of the Radical S-Adenosyl-methionine Thiazole C-Methyltransferase in Thiomuracin Biosynthesis.

Mahanta N, Zhang Z, Hudson GA, van der Donk WA, Mitchell DA. Mahanta N, et al. Among authors: mitchell da. J Am Chem Soc. 2017 Mar 29;139(12):4310-4313. doi: 10.1021/jacs.7b00693. Epub 2017 Mar 21. J Am Chem Soc. 2017. PMID: 28301141 Free PMC article.

8

Mechanism of a Class C Radical S-Adenosyl-l-methionine Thiazole Methyl Transferase.

Zhang Z, Mahanta N, Hudson GA, Mitchell DA, van der Donk WA. Zhang Z, et al. Among authors: mitchell da. J Am Chem Soc. 2017 Dec 27;139(51):18623-18631. doi: 10.1021/jacs.7b10203. Epub 2017 Dec 15. J Am Chem Soc. 2017. PMID: 29190095 Free PMC article.

9

In Vitro Biosynthetic Studies of Bottromycin Expand the Enzymatic Capabilities of the YcaO Superfamily.

Schwalen CJ, Hudson GA, Kosol S, Mahanta N, Challis GL, Mitchell DA. Schwalen CJ, et al. Among authors: mitchell da. J Am Chem Soc. 2017 Dec 20;139(50):18154-18157. doi: 10.1021/jacs.7b09899. Epub 2017 Dec 4. J Am Chem Soc. 2017. PMID: 29200283 Free PMC article.

10

Bioinformatic Expansion and Discovery of Thiopeptide Antibiotics.

Schwalen CJ, Hudson GA, Kille B, Mitchell DA. Schwalen CJ, et al. Among authors: mitchell da. J Am Chem Soc. 2018 Aug 1;140(30):9494-9501. doi: 10.1021/jacs.8b03896. Epub 2018 Jul 20. J Am Chem Soc. 2018. PMID: 29983054 Free PMC article.

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