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T-bet+ B cells are activated by and control endogenous retroviruses through TLR-dependent mechanisms.
Rauch E, Amendt T, Lopez Krol A, Lang FB, Linse V, Hohmann M, Keim AC, Kreutzer S, Kawengian K, Buchholz M, Duschner P, Grauer S, Schnierle B, Ruhl A, Burtscher I, Dehnert S, Kuria C, Kupke A, Paul S, Liehr T, Lechner M, Schnare M, Kaufmann A, Huber M, Winkler TH, Bauer S, Yu P. Rauch E, et al. Among authors: winkler th. Nat Commun. 2024 Feb 9;15(1):1229. doi: 10.1038/s41467-024-45201-6. Nat Commun. 2024. PMID: 38336876 Free PMC article.
Regulation of autoantibody activity by the IL-23-TH17 axis determines the onset of autoimmune disease.
Pfeifle R, Rothe T, Ipseiz N, Scherer HU, Culemann S, Harre U, Ackermann JA, Seefried M, Kleyer A, Uderhardt S, Haugg B, Hueber AJ, Daum P, Heidkamp GF, Ge C, Böhm S, Lux A, Schuh W, Magorivska I, Nandakumar KS, Lönnblom E, Becker C, Dudziak D, Wuhrer M, Rombouts Y, Koeleman CA, Toes R, Winkler TH, Holmdahl R, Herrmann M, Blüml S, Nimmerjahn F, Schett G, Krönke G. Pfeifle R, et al. Among authors: winkler th. Nat Immunol. 2017 Jan;18(1):104-113. doi: 10.1038/ni.3579. Epub 2016 Nov 7. Nat Immunol. 2017. PMID: 27820809 Free PMC article.
CD83 orchestrates immunity toward self and non-self in dendritic cells.
Wild AB, Krzyzak L, Peckert K, Stich L, Kuhnt C, Butterhof A, Seitz C, Mattner J, Grüner N, Gänsbauer M, Purtak M, Soulat D, Winkler TH, Nitschke L, Zinser E, Steinkasserer A. Wild AB, et al. Among authors: winkler th. JCI Insight. 2019 Oct 17;4(20):e126246. doi: 10.1172/jci.insight.126246. JCI Insight. 2019. PMID: 31527313 Free PMC article.
SARS-CoV-2 in severe COVID-19 induces a TGF-β-dominated chronic immune response that does not target itself.
Ferreira-Gomes M, Kruglov A, Durek P, Heinrich F, Tizian C, Heinz GA, Pascual-Reguant A, Du W, Mothes R, Fan C, Frischbutter S, Habenicht K, Budzinski L, Ninnemann J, Jani PK, Guerra GM, Lehmann K, Matz M, Ostendorf L, Heiberger L, Chang HD, Bauherr S, Maurer M, Schönrich G, Raftery M, Kallinich T, Mall MA, Angermair S, Treskatsch S, Dörner T, Corman VM, Diefenbach A, Volk HD, Elezkurtaj S, Winkler TH, Dong J, Hauser AE, Radbruch H, Witkowski M, Melchers F, Radbruch A, Mashreghi MF. Ferreira-Gomes M, et al. Among authors: winkler th. Nat Commun. 2021 Mar 30;12(1):1961. doi: 10.1038/s41467-021-22210-3. Nat Commun. 2021. PMID: 33785765 Free PMC article.
Oligoclonal CD4+CXCR5+ T cells with a cytotoxic phenotype appear in tonsils and blood.
Liang C, Spoerl S, Xiao Y, Habenicht KM, Haeusl SS, Sandner I, Winkler J, Strieder N, Eder R, Stanewsky H, Alexiou C, Dudziak D, Rosenwald A, Edinger M, Rehli M, Hoffmann P, Winkler TH, Berberich-Siebelt F. Liang C, et al. Among authors: winkler th. Commun Biol. 2024 Jul 18;7(1):879. doi: 10.1038/s42003-024-06563-1. Commun Biol. 2024. PMID: 39025930 Free PMC article.
A transgenic marker for mouse B lymphoid precursors.
Mårtensson IL, Melchers F, Winkler TH. Mårtensson IL, et al. Among authors: winkler th. J Exp Med. 1997 Feb 17;185(4):653-61. doi: 10.1084/jem.185.4.653. J Exp Med. 1997. PMID: 9034144 Free PMC article.
139 results