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Circadian control of the secretory pathway maintains collagen homeostasis.
Chang J, Garva R, Pickard A, Yeung CC, Mallikarjun V, Swift J, Holmes DF, Calverley B, Lu Y, Adamson A, Raymond-Hayling H, Jensen O, Shearer T, Meng QJ, Kadler KE. Chang J, et al. Among authors: pickard a. Nat Cell Biol. 2020 Jan;22(1):74-86. doi: 10.1038/s41556-019-0441-z. Epub 2020 Jan 6. Nat Cell Biol. 2020. PMID: 31907414 Free PMC article.
Mmp14 is required for matrisome homeostasis and circadian rhythm in fibroblasts.
Yeung CC, Garva R, Pickard A, Lu Y, Mallikarjun V, Swift J, Taylor SH, Rai J, Eyre DR, Chaturvedi M, Itoh Y, Meng QJ, Mauch C, Zigrino P, Kadler KE. Yeung CC, et al. Among authors: pickard a. Matrix Biol. 2023 Dec;124:8-22. doi: 10.1016/j.matbio.2023.10.002. Epub 2023 Oct 31. Matrix Biol. 2023. PMID: 37913834 Free article.
Preservation of circadian rhythms by the protein folding chaperone, BiP.
Pickard A, Chang J, Alachkar N, Calverley B, Garva R, Arvan P, Meng QJ, Kadler KE. Pickard A, et al. FASEB J. 2019 Jun;33(6):7479-7489. doi: 10.1096/fj.201802366RR. Epub 2019 Mar 19. FASEB J. 2019. PMID: 30888851 Free PMC article.
The significance of these findings was explored in tendon, where we showed that BiP expression is ramped preemptively prior to a surge in collagen synthesis at night, thereby preventing protein misfolding and ER stress. ...Thus, targeting ER stress could be used to modulat …
The significance of these findings was explored in tendon, where we showed that BiP expression is ramped preemptively prior to a surg …
Large-Scale Pharmacogenomics Analysis of Patients With Cancer Within the 100,000 Genomes Project Combining Whole-Genome Sequencing and Medical Records to Inform Clinical Practice.
Leong IUS, Cabrera CP, Cipriani V, Ross PJ, Turner RM, Stuckey A, Sanghvi S, Pasko D, Moutsianas L, Odhams CA, Elgar GS, Chan G, Giess A, Walker S, Foulger RE, Williams EM, Daugherty LC, Rueda-Martin A, Rhodes DJ, Niblock O, Pickard A, Marks L, Leigh SEA, Welland MJ, Bleda M, Snow C, Deans Z, Murugaesu N, Scott RH, Barnes MR, Brown MA, Rendon A, Hill S, Sosinsky A, Caulfield MJ, McDonagh EM. Leong IUS, et al. Among authors: pickard a. J Clin Oncol. 2024 Oct 31:JCO2302761. doi: 10.1200/JCO.23.02761. Online ahead of print. J Clin Oncol. 2024. PMID: 39481076
335 results