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Page 1
Anti-TNF Thioester Glucocorticoid Antibody-Drug Conjugate Fully Inhibits Inflammation with Minimal Effect on Systemic Corticosterone Levels in a Mouse Arthritis Model.
Marvin CC, Hobson AD, McPherson MJ, Hayes ME, Patel MV, Schmidt DL, Li T, Randolph JT, Bischoff AK, Fitzgibbons J, Wang L, Wang L, Hernandez A Jr, Jia Y, Goess CA, Bryant SH, Mathieu SL, Xu J. Marvin CC, et al. Among authors: goess ca. J Med Chem. 2024 Jun 13;67(11):9495-9515. doi: 10.1021/acs.jmedchem.4c00598. Epub 2024 May 23. J Med Chem. 2024. PMID: 38780432
Discovery of ABBV-154, an anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody-Drug Conjugate (iADC).
Hobson AD, Xu J, Welch DS, Marvin CC, McPherson MJ, Gates B, Liao X, Hollmann M, Gattner MJ, Dzeyk K, Sarvaiya H, Shenoy VM, Fettis MM, Bischoff AK, Wang L, Santora LC, Wang L, Fitzgibbons J, Salomon P, Hernandez A Jr, Jia Y, Goess CA, Mathieu SL, Bryant SH, Larsen ME, Cui B, Tian Y. Hobson AD, et al. Among authors: goess ca. J Med Chem. 2023 Sep 14;66(17):12544-12558. doi: 10.1021/acs.jmedchem.3c01174. Epub 2023 Sep 1. J Med Chem. 2023. PMID: 37656698
Optimization of Drug-Linker to Enable Long-term Storage of Antibody-Drug Conjugate for Subcutaneous Dosing.
Hobson AD, Xu J, Marvin CC, McPherson MJ, Hollmann M, Gattner M, Dzeyk K, Fettis MM, Bischoff AK, Wang L, Fitzgibbons J, Wang L, Salomon P, Hernandez A Jr, Jia Y, Sarvaiya H, Goess CA, Mathieu SL, Santora LC. Hobson AD, et al. Among authors: goess ca. J Med Chem. 2023 Jul 13;66(13):9161-9173. doi: 10.1021/acs.jmedchem.3c00794. Epub 2023 Jun 28. J Med Chem. 2023. PMID: 37379257
Correction to "Design and Development of Glucocorticoid Receptor Modulators as Immunology Antibody-Drug Conjugate Payloads".
Hobson AD, McPherson MJ, Waegell W, Goess CA, Stoffel RH, Li X, Zhou J, Wang Z, Yu Y, Hernandez A Jr, Bryant SH, Mathieu SL, Bischoff AK, Fitzgibbons J, Pawlikowska M, Puthenveetil S, Santora LC, Wang L, Wang L, Marvin CC, Hayes ME, Shrestha A, Sarris KA, Li B. Hobson AD, et al. Among authors: goess ca. J Med Chem. 2023 Apr 27;66(8):6011. doi: 10.1021/acs.jmedchem.3c00598. Epub 2023 Apr 14. J Med Chem. 2023. PMID: 37058612 No abstract available.
Design and Development of Glucocorticoid Receptor Modulators as Immunology Antibody-Drug Conjugate Payloads.
Hobson AD, McPherson MJ, Waegell W, Goess CA, Stoffel RH, Li X, Zhou J, Wang Z, Yu Y, Hernandez A Jr, Bryant SH, Mathieu SL, Bischoff AK, Fitzgibbons J, Pawlikowska M, Puthenveetil S, Santora LC, Wang L, Wang L, Marvin CC, Hayes ME, Shrestha A, Sarris KA, Li B. Hobson AD, et al. Among authors: goess ca. J Med Chem. 2022 Mar 24;65(6):4500-4533. doi: 10.1021/acs.jmedchem.1c02099. Epub 2022 Feb 8. J Med Chem. 2022. PMID: 35133822