Iyer MR - Search Results

1

Anandamide is an Early Blood Biomarker of Hermansky-Pudlak Syndrome Pulmonary Fibrosis.

Cinar R, Basu A, Arif M, Park JK, Zawatsky CN, Zuo BLG, Zuo MXG, O'Brien KJ, Behan M, Introne W, Iyer MR, Gahl WA, Malicdan MCV, Gochuico BR. Cinar R, et al. Among authors: iyer mr. medRxiv [Preprint]. 2024 May 17:2024.05.16.24307300. doi: 10.1101/2024.05.16.24307300. medRxiv. 2024. PMID: 38798603 Free PMC article. Preprint.

2

Cannabinoid CB1 receptor overactivity contributes to the pathogenesis of idiopathic pulmonary fibrosis.

Cinar R, Gochuico BR, Iyer MR, Jourdan T, Yokoyama T, Park JK, Coffey NJ, Pri-Chen H, Szanda G, Liu Z, Mackie K, Gahl WA, Kunos G. Cinar R, et al. Among authors: iyer mr. JCI Insight. 2017 Apr 20;2(8):e92281. doi: 10.1172/jci.insight.92281. eCollection 2017 Apr 20. JCI Insight. 2017. PMID: 28422760 Free PMC article.

3

Synthesis of ¹³ C₆ -labeled, dual-target inhibitor of cannabinoid-1 receptor (CB₁ R) and inducible nitric oxide synthase (iNOS).

Iyer MR, Cinar R, Coffey NJ, Kunos G. Iyer MR, et al. J Labelled Comp Radiopharm. 2018 May 23. doi: 10.1002/jlcr.3639. Online ahead of print. J Labelled Comp Radiopharm. 2018. PMID: 29790591

4

The therapeutic potential of second and third generation CB₁R antagonists.

Cinar R, Iyer MR, Kunos G. Cinar R, et al. Among authors: iyer mr. Pharmacol Ther. 2020 Apr;208:107477. doi: 10.1016/j.pharmthera.2020.107477. Epub 2020 Jan 9. Pharmacol Ther. 2020. PMID: 31926199 Free PMC article. Review.

5

Dual inhibition of CB₁ receptors and iNOS, as a potential novel approach to the pharmacological management of acute and long COVID-19.

Cinar R, Iyer MR, Kunos G. Cinar R, et al. Among authors: iyer mr. Br J Pharmacol. 2022 May;179(10):2121-2127. doi: 10.1111/bph.15461. Epub 2021 Apr 17. Br J Pharmacol. 2022. PMID: 33769552 Free PMC article.

6

Functional Selectivity of a Biased Cannabinoid-1 Receptor (CB₁R) Antagonist.

Liu Z, Iyer MR, Godlewski G, Jourdan T, Liu J, Coffey NJ, Zawatsky CN, Puhl HL, Wess J, Meister J, Liow JS, Innis RB, Hassan SA, Lee YS, Kunos G, Cinar R. Liu Z, et al. Among authors: iyer mr. ACS Pharmacol Transl Sci. 2021 Apr 8;4(3):1175-1187. doi: 10.1021/acsptsci.1c00048. eCollection 2021 Jun 11. ACS Pharmacol Transl Sci. 2021. PMID: 34151207 Free PMC article.

7

CB₁ R and iNOS are distinct players promoting pulmonary fibrosis in Hermansky-Pudlak syndrome.

Cinar R, Park JK, Zawatsky CN, Coffey NJ, Bodine SP, Abdalla J, Yokoyama T, Jourdan T, Jay L, Zuo MXG, O'Brien KJ, Huang J, Mackie K, Alimardanov A, Iyer MR, Gahl WA, Kunos G, Gochuico BR, Malicdan MCV. Cinar R, et al. Among authors: iyer mr. Clin Transl Med. 2021 Jul;11(7):e471. doi: 10.1002/ctm2.471. Clin Transl Med. 2021. PMID: 34323400 Free PMC article.

8

Effects of a Peripherally Restricted Hybrid Inhibitor of CB1 Receptors and iNOS on Alcohol Drinking Behavior and Alcohol-Induced Endotoxemia.

Santos-Molina L, Herrerias A, Zawatsky CN, Gunduz-Cinar O, Cinar R, Iyer MR, Wood CM, Lin Y, Gao B, Kunos G, Godlewski G. Santos-Molina L, et al. Among authors: iyer mr. Molecules. 2021 Aug 22;26(16):5089. doi: 10.3390/molecules26165089. Molecules. 2021. PMID: 34443679 Free PMC article.

9

Peripheral Hybrid CB₁R and iNOS Antagonist MRI-1867 Displays Anti-Fibrotic Efficacy in Bleomycin-Induced Skin Fibrosis.

Zawatsky CN, Park JK, Abdalla J, Kunos G, Iyer MR, Cinar R. Zawatsky CN, et al. Among authors: iyer mr. Front Endocrinol (Lausanne). 2021 Sep 28;12:744857. doi: 10.3389/fendo.2021.744857. eCollection 2021. Front Endocrinol (Lausanne). 2021. PMID: 34650521 Free PMC article.

10

Synthesis, Biological Evaluation, and Molecular Modeling Studies of 3,4-Diarylpyrazoline Series of Compounds as Potent, Nonbrain Penetrant Antagonists of Cannabinoid-1 (CB₁R) Receptor with Reduced Lipophilicity.

Iyer MR, Cinar R, Wood CM, Zawatsky CN, Coffey NJ, Kim KA, Liu Z, Katz A, Abdalla J, Hassan SA, Lee YS. Iyer MR, et al. J Med Chem. 2022 Feb 10;65(3):2374-2387. doi: 10.1021/acs.jmedchem.1c01836. Epub 2022 Jan 27. J Med Chem. 2022. PMID: 35084860

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