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Targeted complement inhibition using bispecific antibodies that bind local antigens and endogenous complement regulators.
Wang H, van de Bovenkamp FS, Dijkstra DJ, Abendstein L, Borggreven NV, Pool J, Zuijderduijn R, Gstöttner C, Gelderman KA, Damelang T, Vidarsson G, Blom AM, Domínguez-Vega E, Parren PWHI, Sharp TH, Trouw LA. Wang H, et al. Among authors: dijkstra dj. Front Immunol. 2024 May 16;15:1288597. doi: 10.3389/fimmu.2024.1288597. eCollection 2024. Front Immunol. 2024. PMID: 38817607 Free PMC article.
Complement activation and regulation in rheumatic disease.
Dijkstra DJ, Joeloemsingh JV, Bajema IM, Trouw LA. Dijkstra DJ, et al. Semin Immunol. 2019 Oct;45:101339. doi: 10.1016/j.smim.2019.101339. Epub 2019 Nov 9. Semin Immunol. 2019. PMID: 31718864 Free article. Review.
Carbamylation reduces the capacity of IgG for hexamerization and complement activation.
Lubbers R, Oostindie SC, Dijkstra DJ, Parren PWHI, Verheul MK, Abendstein L, Sharp TH, de Ru A, Janssen GMC, van Veelen PA, van den Bremer ETJ, Bleijlevens B, de Kreuk BJ, Beurskens FJ, Trouw LA. Lubbers R, et al. Among authors: dijkstra dj. Clin Exp Immunol. 2020 Apr;200(1):1-11. doi: 10.1111/cei.13411. Epub 2020 Jan 5. Clin Exp Immunol. 2020. PMID: 31853959 Free PMC article.
Expression and production of the SERPING1-encoded endogenous complement regulator C1-inhibitor in multiple cohorts of tuberculosis patients.
Lubbers R, Sutherland JS, Goletti D, de Paus RA, Dijkstra DJ, van Moorsel CHM, Veltkamp M, Vestjens SMT, Bos WJW, Petrone L, Malherbe ST, Walzl G, Gelderman KA, Groeneveld GH, Geluk A, Ottenhoff THM, Joosten SA, Trouw LA. Lubbers R, et al. Among authors: dijkstra dj. Mol Immunol. 2020 Apr;120:187-195. doi: 10.1016/j.molimm.2020.02.006. Epub 2020 Mar 13. Mol Immunol. 2020. PMID: 32179338 Free article.
Inverse correlation between serum complement component C1q levels and whole blood type-1 interferon signature in active tuberculosis and QuantiFERON-positive uveitis: implications for diagnosis.
Schrijver B, Dijkstra DJ, Borggreven NV, La Distia Nora R, Huijser E, Versnel MA, van Hagen PM, Joosten SA, Trouw LA, Dik WA. Schrijver B, et al. Among authors: dijkstra dj. Clin Transl Immunology. 2020 Oct 16;9(10):e1196. doi: 10.1002/cti2.1196. eCollection 2020. Clin Transl Immunology. 2020. PMID: 33088504 Free PMC article.
Circulating C1q levels in health and disease, more than just a biomarker.
van de Bovenkamp FS, Dijkstra DJ, van Kooten C, Gelderman KA, Trouw LA. van de Bovenkamp FS, et al. Among authors: dijkstra dj. Mol Immunol. 2021 Dec;140:206-216. doi: 10.1016/j.molimm.2021.10.010. Epub 2021 Nov 2. Mol Immunol. 2021. PMID: 34735869 Free article. Review.
Circulating Levels of Anti-C1q and Anti-Factor H Autoantibodies and Their Targets in Normal Pregnancy and Preeclampsia.
Dijkstra DJ, Lokki AI, Gierman LM, Borggreven NV, van der Keur C, Eikmans M, Gelderman KA, Laivuori H; FINNPEC Core Investigator Group; Iversen AC, van der Hoorn MP, Trouw LA. Dijkstra DJ, et al. Front Immunol. 2022 Mar 31;13:842451. doi: 10.3389/fimmu.2022.842451. eCollection 2022. Front Immunol. 2022. PMID: 35432365 Free PMC article.
PTX3 structure determination using a hybrid cryoelectron microscopy and AlphaFold approach offers insights into ligand binding and complement activation.
Noone DP, Dijkstra DJ, van der Klugt TT, van Veelen PA, de Ru AH, Hensbergen PJ, Trouw LA, Sharp TH. Noone DP, et al. Among authors: dijkstra dj. Proc Natl Acad Sci U S A. 2022 Aug 16;119(33):e2208144119. doi: 10.1073/pnas.2208144119. Epub 2022 Aug 8. Proc Natl Acad Sci U S A. 2022. PMID: 35939690 Free PMC article.
25 results