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Targeted complement inhibition using bispecific antibodies that bind local antigens and endogenous complement regulators.
Wang H, van de Bovenkamp FS, Dijkstra DJ, Abendstein L, Borggreven NV, Pool J, Zuijderduijn R, Gstöttner C, Gelderman KA, Damelang T, Vidarsson G, Blom AM, Domínguez-Vega E, Parren PWHI, Sharp TH, Trouw LA. Wang H, et al. Among authors: zuijderduijn r. Front Immunol. 2024 May 16;15:1288597. doi: 10.3389/fimmu.2024.1288597. eCollection 2024. Front Immunol. 2024. PMID: 38817607 Free PMC article.
Human anti-C1q autoantibodies bind specifically to solid-phase C1q and enhance phagocytosis but not complement activation.
Dijkstra DJ, van de Bovenkamp FS, Abendstein L, Zuijderduijn R, Pool J, Kramer CSM, Slot LM, Drijfhout JW, de Vor L, Gelderman KA, Rooijakkers SHM, Zaldumbide A, Vidarsson G, Sharp TH, Parren PWHI, Trouw LA. Dijkstra DJ, et al. Among authors: zuijderduijn r. Proc Natl Acad Sci U S A. 2023 Dec 12;120(50):e2310666120. doi: 10.1073/pnas.2310666120. Epub 2023 Dec 4. Proc Natl Acad Sci U S A. 2023. PMID: 38048459 Free PMC article.