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Page 1
Exploration and optimisation of structure-activity relationships of new triazole-based C-terminal Hsp90 inhibitors towards in vivo anticancer potency.
Dernovšek J, Zajec Ž, Poje G, Urbančič D, Sturtzel C, Goričan T, Grissenberger S, Ciura K, Woziński M, Gedgaudas M, Zubrienė A, Grdadolnik SG, Mlinarič-Raščan I, Rajić Z, Cotman AE, Zidar N, Distel M, Tomašič T. Dernovšek J, et al. Among authors: cotman ae. Biomed Pharmacother. 2024 Aug;177:116941. doi: 10.1016/j.biopha.2024.116941. Epub 2024 Jun 17. Biomed Pharmacother. 2024. PMID: 38889640 Free article.
Practical Synthesis and Application of Halogen-Doped Pyrrole Building Blocks.
Cotman AE, Guérin T, Kovačević I, Benedetto Tiz D, Durcik M, Fulgheri F, Možina Š, Secci D, Sterle M, Ilaš J, Zega A, Zidar N, Mašič LP, Tomašič T, Leroux FR, Hanquet G, Kikelj D. Cotman AE, et al. ACS Omega. 2021 Mar 30;6(14):9723-9730. doi: 10.1021/acsomega.1c00331. eCollection 2021 Apr 13. ACS Omega. 2021. PMID: 33869952 Free PMC article.
Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold-Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa.
Cotman AE, Durcik M, Benedetto Tiz D, Fulgheri F, Secci D, Sterle M, Možina Š, Skok Ž, Zidar N, Zega A, Ilaš J, Peterlin Mašič L, Tomašič T, Hughes D, Huseby DL, Cao S, Garoff L, Berruga Fernández T, Giachou P, Crone L, Simoff I, Svensson R, Birnir B, Korol SV, Jin Z, Vicente F, Ramos MC, de la Cruz M, Glinghammar B, Lenhammar L, Henderson SR, Mundy JEA, Maxwell A, Stevenson CEM, Lawson DM, Janssen GV, Sterk GJ, Kikelj D. Cotman AE, et al. J Med Chem. 2023 Jan 26;66(2):1380-1425. doi: 10.1021/acs.jmedchem.2c01597. Epub 2023 Jan 12. J Med Chem. 2023. PMID: 36634346 Free PMC article.
New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate Staphylococcus aureus.
Durcik M, Cotman AE, Toplak Ž, Možina Š, Skok Ž, Szili PE, Czikkely M, Maharramov E, Vu TH, Piras MV, Zidar N, Ilaš J, Zega A, Trontelj J, Pardo LA, Hughes D, Huseby D, Berruga-Fernández T, Cao S, Simoff I, Svensson R, Korol SV, Jin Z, Vicente F, Ramos MC, Mundy JEA, Maxwell A, Stevenson CEM, Lawson DM, Glinghammar B, Sjöström E, Bohlin M, Oreskär J, Alvér S, Janssen GV, Sterk GJ, Kikelj D, Pal C, Tomašič T, Peterlin Mašič L. Durcik M, et al. Among authors: cotman ae. J Med Chem. 2023 Mar 23;66(6):3968-3994. doi: 10.1021/acs.jmedchem.2c01905. Epub 2023 Mar 6. J Med Chem. 2023. PMID: 36877255 Free PMC article.
Exploring the 5-Substituted 2-Aminobenzothiazole-Based DNA Gyrase B Inhibitors Active against ESKAPE Pathogens.
Sterle M, Durcik M, Stevenson CEM, Henderson SR, Szili PE, Czikkely M, Lawson DM, Maxwell A, Cahard D, Kikelj D, Zidar N, Pal C, Mašič LP, Ilaš J, Tomašič T, Cotman AE, Zega A. Sterle M, et al. Among authors: cotman ae. ACS Omega. 2023 Jun 28;8(27):24387-24395. doi: 10.1021/acsomega.3c01930. eCollection 2023 Jul 11. ACS Omega. 2023. PMID: 37457471 Free PMC article.
Development of narrow-spectrum topoisomerase-targeting antibacterials against mycobacteria.
Sterle M, Habjan E, Piga M, Peršolja P, Durcik M, Dernovšek J, Szili P, Czikkely MS, Zidar N, Janez I, Pal C, Accetto T, Pardo LA, Kikelj D, Peterlin Mašič L, Tomašič T, Bitter W, Cotman AE, Speer A, Zega A. Sterle M, et al. Among authors: cotman ae. Eur J Med Chem. 2024 Oct 5;276:116693. doi: 10.1016/j.ejmech.2024.116693. Epub 2024 Jul 19. Eur J Med Chem. 2024. PMID: 39053193
Improved N-phenylpyrrolamide inhibitors of DNA gyrase as antibacterial agents for high-priority bacterial strains.
Zidar N, Onali A, Peršolja P, Benedetto Tiz D, Dernovšek J, Skok Ž, Durcik M, Cotman AE, Hrast Rambaher M, Cruz CD, Tammela P, Senerovic L, Jovanovic M, Szili PÉ, Czikkely MS, Pál C, Zega A, Peterlin Mašič L, Ilaš J, Tomašič T, Kikelj D. Zidar N, et al. Among authors: cotman ae. Eur J Med Chem. 2024 Nov 15;278:116823. doi: 10.1016/j.ejmech.2024.116823. Epub 2024 Sep 1. Eur J Med Chem. 2024. PMID: 39236496 Free article.
New N-phenylpyrrolamide inhibitors of DNA gyrase with improved antibacterial activity.
Cotman AE, Fulgheri F, Piga M, Peršolja P, Tiz DB, Skok Ž, Durcik M, Sterle M, Dernovšek J, Cruz CD, Tammela P, Szili PÉ, Daruka L, Pál C, Zega A, Mašič LP, Ilaš J, Tomašič T, Kikelj D, Zidar N. Cotman AE, et al. RSC Adv. 2024 Sep 6;14(39):28423-28454. doi: 10.1039/d4ra04802d. eCollection 2024 Sep 4. RSC Adv. 2024. PMID: 39247510 Free PMC article.
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