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Page 1
First dual inhibitors of human topoisomerase IIα and Hsp90 C-terminal domain inhibit the growth of Ewing sarcoma in vitro and in vivo.
Dernovšek J, Urbančič D, Zajec Ž, Sturtzel C, Grissenberger S, Wenninger-Weinzierl A, Gedgaudas M, Zubrienė A, Goričan T, Golič Grdadolnik S, Skok Ž, Ilaš J, Distel M, Zidar N, Tomašič T. Dernovšek J, et al. Bioorg Chem. 2024 Oct 1;153:107850. doi: 10.1016/j.bioorg.2024.107850. Online ahead of print. Bioorg Chem. 2024. PMID: 39395321 Free article.
Hiding in plain sight: Optimizing topoisomerase IIα inhibitors into Hsp90β selective binders.
Dernovšek J, Goričan T, Gedgaudas M, Zajec Ž, Urbančič D, Jug A, Skok Ž, Sturtzel C, Distel M, Grdadolnik SG, Babu K, Panchamatia A, Stachowski TR, Fischer M, Ilaš J, Zubrienė A, Matulis D, Zidar N, Tomašič T. Dernovšek J, et al. Eur J Med Chem. 2024 Oct 5;280:116934. doi: 10.1016/j.ejmech.2024.116934. Online ahead of print. Eur J Med Chem. 2024. PMID: 39388906 Free article.
New N-phenylpyrrolamide inhibitors of DNA gyrase with improved antibacterial activity.
Cotman AE, Fulgheri F, Piga M, Peršolja P, Tiz DB, Skok Ž, Durcik M, Sterle M, Dernovšek J, Cruz CD, Tammela P, Szili PÉ, Daruka L, Pál C, Zega A, Mašič LP, Ilaš J, Tomašič T, Kikelj D, Zidar N. Cotman AE, et al. Among authors: dernovsek j. RSC Adv. 2024 Sep 6;14(39):28423-28454. doi: 10.1039/d4ra04802d. eCollection 2024 Sep 4. RSC Adv. 2024. PMID: 39247510 Free PMC article.
Improved N-phenylpyrrolamide inhibitors of DNA gyrase as antibacterial agents for high-priority bacterial strains.
Zidar N, Onali A, Peršolja P, Benedetto Tiz D, Dernovšek J, Skok Ž, Durcik M, Cotman AE, Hrast Rambaher M, Cruz CD, Tammela P, Senerovic L, Jovanovic M, Szili PÉ, Czikkely MS, Pál C, Zega A, Peterlin Mašič L, Ilaš J, Tomašič T, Kikelj D. Zidar N, et al. Among authors: dernovsek j. Eur J Med Chem. 2024 Nov 15;278:116823. doi: 10.1016/j.ejmech.2024.116823. Epub 2024 Sep 1. Eur J Med Chem. 2024. PMID: 39236496 Free article.
Development of narrow-spectrum topoisomerase-targeting antibacterials against mycobacteria.
Sterle M, Habjan E, Piga M, Peršolja P, Durcik M, Dernovšek J, Szili P, Czikkely MS, Zidar N, Janez I, Pal C, Accetto T, Pardo LA, Kikelj D, Peterlin Mašič L, Tomašič T, Bitter W, Cotman AE, Speer A, Zega A. Sterle M, et al. Among authors: dernovsek j. Eur J Med Chem. 2024 Oct 5;276:116693. doi: 10.1016/j.ejmech.2024.116693. Epub 2024 Jul 19. Eur J Med Chem. 2024. PMID: 39053193
Exploration and optimisation of structure-activity relationships of new triazole-based C-terminal Hsp90 inhibitors towards in vivo anticancer potency.
Dernovšek J, Zajec Ž, Poje G, Urbančič D, Sturtzel C, Goričan T, Grissenberger S, Ciura K, Woziński M, Gedgaudas M, Zubrienė A, Grdadolnik SG, Mlinarič-Raščan I, Rajić Z, Cotman AE, Zidar N, Distel M, Tomašič T. Dernovšek J, et al. Biomed Pharmacother. 2024 Aug;177:116941. doi: 10.1016/j.biopha.2024.116941. Epub 2024 Jun 17. Biomed Pharmacother. 2024. PMID: 38889640 Free article.
19 results