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551 results

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Restoring hippocampal glucose metabolism rescues cognition across Alzheimer's disease pathologies.
Minhas PS, Jones JR, Latif-Hernandez A, Sugiura Y, Durairaj AS, Uenaka T, Wang Q, Mhatre SD, Liu L, Conley T, Ennerfelt H, Jung YJ, Prasad P, Jenkins BC, Goodman R, Newmeyer T, Heard K, Kang A, Wilson EN, Ullian EM, Serrano GE, Beach TG, Rabinowitz JD, Wernig M, Suematsu M, Longo FM, McReynolds MR, Gage FH, Andreasson KI. Minhas PS, et al. Among authors: beach tg. bioRxiv [Preprint]. 2024 Jun 28:2024.06.23.598940. doi: 10.1101/2024.06.23.598940. bioRxiv. 2024. Update in: Science. 2024 Aug 23;385(6711):eabm6131. doi: 10.1126/science.abm6131. PMID: 38979192 Free PMC article. Updated. Preprint.
Low circulating choline, a modifiable dietary factor, is associated with the pathological progression and metabolome dysfunction in Alzheimer's disease.
Judd JM, Jasbi P, Winslow W, Serrano GE, Beach TG, Klein-Seetharaman J, Velazquez R. Judd JM, et al. Among authors: beach tg. bioRxiv [Preprint]. 2023 May 8:2023.05.06.539713. doi: 10.1101/2023.05.06.539713. bioRxiv. 2023. Update in: Acta Neuropathol. 2023 Oct;146(4):565-583. doi: 10.1007/s00401-023-02616-7. PMID: 37214864 Free PMC article. Updated. Preprint.
APOE4/4 is linked to damaging lipid droplets in Alzheimer's microglia.
Haney MS, Pálovics R, Munson CN, Long C, Johansson P, Yip O, Dong W, Rawat E, West E, Schlachetzki JC, Tsai A, Guldner IH, Lamichhane BS, Smith A, Schaum N, Calcuttawala K, Shin A, Wang YH, Wang C, Koutsodendris N, Serrano GE, Beach TG, Reiman EM, Glass CK, Abu-Remaileh M, Enejder A, Huang Y, Wyss-Coray T. Haney MS, et al. Among authors: beach tg. bioRxiv [Preprint]. 2023 Jul 25:2023.07.21.549930. doi: 10.1101/2023.07.21.549930. bioRxiv. 2023. Update in: Nature. 2024 Apr;628(8006):154-161. doi: 10.1038/s41586-024-07185-7. PMID: 37546938 Free PMC article. Updated. Preprint.
Comorbidities in Early-Onset Sporadic versus Presenilin-1 Mutation-Associated Alzheimer's Disease Dementia: Evidence for Dependency on Alzheimer's Disease Neuropathological Changes.
Sepulveda-Falla D, Lanau CAV, White C 3rd, Serrano GE, Acosta-Uribe J, Mejía-Cupajita B, Villalba-Moreno ND, Lu P, Glatzel M, Kofler JK, Ghetti B, Frosch MP, Restrepo FL, Kosik KS, Beach TG. Sepulveda-Falla D, et al. Among authors: beach tg. medRxiv [Preprint]. 2023 Aug 16:2023.08.14.23294081. doi: 10.1101/2023.08.14.23294081. medRxiv. 2023. PMID: 37646002 Free PMC article. Preprint.
A public resource of single cell transcriptomes and multiscale networks from persons with and without Alzheimer's disease.
Wang Q, Antone J, Alsop E, Reiman R, Funk C, Bendl J, Dudley JT, Liang WS, Karr TL, Roussos P, Bennett DA, De Jager PL, Serrano GE, Beach TG, Keuren-Jensen KV, Mastroeni D, Reiman EM, Readhead BP. Wang Q, et al. Among authors: beach tg. bioRxiv [Preprint]. 2023 Oct 24:2023.10.20.563319. doi: 10.1101/2023.10.20.563319. bioRxiv. 2023. Update in: Nat Commun. 2024 Jul 10;15(1):5815. doi: 10.1038/s41467-024-49790-0. PMID: 37961404 Free PMC article. Updated. Preprint.
TREM1 disrupts myeloid bioenergetics and cognitive function in aging and Alzheimer disease mouse models.
Wilson EN, Wang C, Swarovski MS, Zera KA, Ennerfelt HE, Wang Q, Chaney A, Gauba E, Ramos Benitez JA, Le Guen Y, Minhas PS, Panchal M, Tan YJ, Blacher E, A Iweka C, Cropper H, Jain P, Liu Q, Mehta SS, Zuckerman AJ, Xin M, Umans J, Huang J, Durairaj AS, Serrano GE, Beach TG, Greicius MD, James ML, Buckwalter MS, McReynolds MR, Rabinowitz JD, Andreasson KI. Wilson EN, et al. Among authors: beach tg. Nat Neurosci. 2024 May;27(5):873-885. doi: 10.1038/s41593-024-01610-w. Epub 2024 Mar 27. Nat Neurosci. 2024. PMID: 38539014 Free PMC article.
Large-scale Deep Proteomic Analysis in Alzheimer's Disease Brain Regions Across Race and Ethnicity.
Seifar F, Fox EJ, Shantaraman A, Liu Y, Dammer EB, Modeste E, Duong DM, Yin L, Trautwig AN, Guo Q, Xu K, Ping L, Reddy JS, Allen M, Quicksall Z, Heath L, Scanlan J, Wang E, Wang M, Linden AV, Poehlman W, Chen X, Baheti S, Ho C, Nguyen T, Yepez G, Mitchell AO, Oatman SR, Wang X, Carrasquillo MM, Runnels A, Beach T, Serrano GE, Dickson DW, Lee EB, Golde TE, Prokop S, Barnes LL, Zhang B, Haroutunian V, Gearing M, Lah JJ, Jager P, Bennett DA, Greenwood A, Ertekin-Taner N, Levey AI, Wingo A, Wingo T, Seyfried NT. Seifar F, et al. bioRxiv [Preprint]. 2024 Apr 26:2024.04.22.590547. doi: 10.1101/2024.04.22.590547. bioRxiv. 2024. PMID: 38712030 Free PMC article. Preprint.
Measuring up: A Comparison of Tapestation 4200 and Bioanalyzer 2100 as Measurement Tools for RNA Quality in Postmortem Human Brain Samples.
Walker JE, Oliver JC, Stewart AM, Beh ST, Arce RA, Glass MJ, Vargas DE, Qiji SH, Intorcia AJ, Borja CI, Cline MP, Hemmingsen SJ, Krupp AN, McHattie RD, Mariner MR, Lorenzini I, Aslam S, Tremblay C, Beach TG, Serrano GE. Walker JE, et al. Among authors: beach tg. medRxiv [Preprint]. 2023 Jul 6:2023.07.03.23291969. doi: 10.1101/2023.07.03.23291969. medRxiv. 2023. Update in: Int J Mol Sci. 2023 Sep 07;24(18):13795. doi: 10.3390/ijms241813795. PMID: 37461632 Free PMC article. Updated. Preprint.
551 results