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Biopsy samples from patients with irritable bowel syndrome, but not from those with mastocytosis or unspecific gastrointestinal complaints reveal unique nerve activation in all gut regions independent of mast cell density, histamine content or specific gastrointestinal symptoms.
Vignali S, Buhner S, Greiter W, Daniel H, Frieling T, Schemann M, Annahazi A. Vignali S, et al. Front Neurosci. 2024 Jul 2;18:1291554. doi: 10.3389/fnins.2024.1291554. eCollection 2024. Front Neurosci. 2024. PMID: 39015376 Free PMC article.
Protease signaling through protease activated receptor 1 mediate nerve activation by mucosal supernatants from irritable bowel syndrome but not from ulcerative colitis patients.
Buhner S, Hahne H, Hartwig K, Li Q, Vignali S, Ostertag D, Meng C, Hörmannsperger G, Braak B, Pehl C, Frieling T, Barbara G, De Giorgio R, Demir IE, Ceyhan GO, Zeller F, Boeckxstaens G, Haller D, Kuster B, Schemann M. Buhner S, et al. Among authors: vignali s. PLoS One. 2018 Mar 12;13(3):e0193943. doi: 10.1371/journal.pone.0193943. eCollection 2018. PLoS One. 2018. PMID: 29529042 Free PMC article.
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