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Pharmacologic inhibition of dipeptidyl peptidase 1 (cathepsin C) does not block in vitro granzyme-mediated target cell killing by CD8 T or NK cells.
Sutton VR, Watt SV, Akhlaghi H, Cipolla DC, Chen KJ, LaSala D, McDonald PP, Beavis PA, Munoz I, Hodel AW, Noori T, Voskoboinik I, Trapani JA. Sutton VR, et al. Among authors: mcdonald pp. Front Pharmacol. 2024 Jul 3;15:1396710. doi: 10.3389/fphar.2024.1396710. eCollection 2024. Front Pharmacol. 2024. PMID: 39021839 Free PMC article.
The pharmacokinetic profile of brensocatib and its effect on pharmacodynamic biomarkers including NE, PR3, and CatG in various rodent species.
Basso J, Chen KJ, Zhou Y, Mark L, LaSala D, Dorfman A, Atalla M, Chun D, Viramontes V, Chang C, Leifer F, McDonald PP, Cipolla DC. Basso J, et al. Among authors: mcdonald pp. Front Pharmacol. 2023 Jul 19;14:1208780. doi: 10.3389/fphar.2023.1208780. eCollection 2023. Front Pharmacol. 2023. PMID: 37538173 Free PMC article.
Pharmacological inhibition of cathepsin S and of NSPs-AAP-1 (a novel, alternative protease driving the activation of neutrophil serine proteases).
Domain R, Seren S, Jerke U, Makridakis M, Chen KJ, Zoidakis J, Rhimi M, Zhang X, Bonvent T, Croix C, Gonzalez L, Li D, Basso J, Paget C, Viaud-Massuard MC, Lalmanach G, Shi GP, Aghdassi A, Vlahou A, McDonald PP, Couillin I, Williams R, Kettritz R, Korkmaz B. Domain R, et al. Among authors: mcdonald pp. Biochem Pharmacol. 2024 Nov;229:116114. doi: 10.1016/j.bcp.2024.116114. Epub 2024 Sep 16. Biochem Pharmacol. 2024. PMID: 39455238 Free article.
77 results