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Valproic acid targets IDH1 mutants through alteration of lipid metabolism.
Elahi LS, Condro MC, Kawaguchi R, Qin Y, Alvarado AG, Gruender B, Qi H, Li T, Lai A, Castro MG, Lowenstein PR, Garrett MC, Kornblum HI. Elahi LS, et al. Among authors: li t. NPJ Metab Health Dis. 2024;2(1):20. doi: 10.1038/s44324-024-00021-6. Epub 2024 Aug 13. NPJ Metab Health Dis. 2024. PMID: 39149696 Free PMC article.
D-2-HG Inhibits IDH1mut Glioma Growth via FTO Inhibition and Resultant m6A Hypermethylation.
Pianka ST, Li T, Prins TJ, Eldred BSC, Kevan BM, Liang H, Zapanta Rinonos S, Kornblum HI, Nathanson DA, Pellegrini M, Liau LM, Nghiemphu PL, Cloughesy TF, Lai A. Pianka ST, et al. Among authors: li t. Cancer Res Commun. 2024 Mar 22;4(3):876-894. doi: 10.1158/2767-9764.CRC-23-0271. Cancer Res Commun. 2024. PMID: 38445960 Free PMC article.
SPINT2 is hypermethylated in both IDH1 mutated and wild-type glioblastomas, and exerts tumor suppression via reduction of c-Met activation.
Liu F, Cox CD, Chowdhury R, Dovek L, Nguyen H, Li T, Li S, Ozer B, Chou A, Nguyen N, Wei B, Antonios J, Soto H, Kornblum H, Liau L, Prins R, Nghiemphu PL, Yong W, Cloughesy T, Lai A. Liu F, et al. Among authors: li s, li t. J Neurooncol. 2019 May;142(3):423-434. doi: 10.1007/s11060-019-03126-x. Epub 2019 Mar 5. J Neurooncol. 2019. PMID: 30838489 Free PMC article.
Tumor-suppressive miR148a is silenced by CpG island hypermethylation in IDH1-mutant gliomas.
Li S, Chowdhury R, Liu F, Chou AP, Li T, Mody RR, Lou JJ, Chen W, Reiss J, Soto H, Prins R, Liau LM, Mischel PS, Nghiemphu PL, Yong WH, Cloughesy TF, Lai A. Li S, et al. Among authors: li t. Clin Cancer Res. 2014 Nov 15;20(22):5808-22. doi: 10.1158/1078-0432.CCR-14-0234. Epub 2014 Sep 15. Clin Cancer Res. 2014. PMID: 25224277 Free PMC article.
Human TERT promoter mutation enables survival advantage from MGMT promoter methylation in IDH1 wild-type primary glioblastoma treated by standard chemoradiotherapy.
Nguyen HN, Lie A, Li T, Chowdhury R, Liu F, Ozer B, Wei B, Green RM, Ellingson BM, Wang HJ, Elashoff R, Liau LM, Yong WH, Nghiemphu PL, Cloughesy T, Lai A. Nguyen HN, et al. Among authors: li t. Neuro Oncol. 2017 Mar 1;19(3):394-404. doi: 10.1093/neuonc/now189. Neuro Oncol. 2017. PMID: 27571882 Free PMC article.
Retrospective examination of pseudoprogression in IDH mutant gliomas.
Wetzel EA, Farrell MJ, Eldred BSC, Liu V, Saha I, Zapanta Rinonos S, Prins T, Li T, Cao M, Hegde J, Kaprealian T, Khanlou N, Liau LM, Nghiemphu PL, Cloughesy TF, Chong RA, Ellingson BM, Lai A. Wetzel EA, et al. Among authors: li t. Neurooncol Adv. 2023 Mar 18;5(1):vdad028. doi: 10.1093/noajnl/vdad028. eCollection 2023 Jan-Dec. Neurooncol Adv. 2023. PMID: 37128507 Free PMC article.
Targeted next-generation sequencing of 565 neuro-oncology patients at UCLA: A single-institution experience.
Ji MS, Eldred BSC, Liu R, Pianka ST, Molaie D, Kevan B, Pan S, Lai TJ, Nguyen NT, Chow FE, Yong WH, Cox CD, Reeh DN, Li T, Liau LM, Nghiemphu PL, Cloughesy TF, Li G, Lai A. Ji MS, et al. Among authors: li t, li g. Neurooncol Adv. 2020 Jan-Dec;2(1):vdaa009. doi: 10.1093/noajnl/vdaa009. Epub 2020 Jan 29. Neurooncol Adv. 2020. PMID: 32118206 Free PMC article.
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