Han H - Search Results

1

Acid-degradable lipid nanoparticles enhance the delivery of mRNA.

Zhao S, Gao K, Han H, Stenzel M, Yin B, Song H, Lawanprasert A, Nielsen JE, Sharma R, Arogundade OH, Pimcharoen S, Chen YJ, Paul A, Tuma J, Collins MG, Wyle Y, Cranick MG, Burgstone BW, Perez BS, Barron AE, Smith AM, Lee HY, Wang A, Murthy N. Zhao S, et al. Among authors: han h. Nat Nanotechnol. 2024 Nov;19(11):1702-1711. doi: 10.1038/s41565-024-01765-4. Epub 2024 Aug 23. Nat Nanotechnol. 2024. PMID: 39179796

2

A novel fluorescent surfactant enhances the delivery of the Cas9 ribonucleoprotein and enables the identification of edited cells.

Li J , Røise JJ , Zhang J , Yang J , Kerr DL , Han H , Murthy N . Li J , et al. Among authors: han h. Chem Commun (Camb). 2019 Apr 11;55(31):4562-4565. doi: 10.1039/c9cc00261h. Chem Commun (Camb). 2019. PMID: 30931453 Free PMC article.

3

A pH-sensitive eosin-block copolymer delivers proteins intracellularly.

Reinhard S , Han H , Tuma J , Røise JJ , Li IC , Li J , Lee HY , Murthy N . Reinhard S , et al. Among authors: han h. Chem Commun (Camb). 2020 Nov 25;56(91):14207-14210. doi: 10.1039/d0cc05165a. Epub 2020 Oct 28. Chem Commun (Camb). 2020. PMID: 33111731 Free PMC article.

4

A traceless linker for aliphatic amines that rapidly and quantitatively fragments after reduction.

He M, Li J, Han H, Borges CA, Neiman G, Røise JJ, Hadaczek P, Mendonsa R, Holm VR, Wilson RC, Bankiewicz K, Zhang Y, Sadlowski CM, Healy K, Riley LW, Murthy N. He M, et al. Among authors: han h. Chem Sci. 2020 Aug 12;11(33):8973-8980. doi: 10.1039/d0sc00929f. Chem Sci. 2020. PMID: 34123152 Free PMC article.

5

The Coiled-Coil Forming Peptide (KVSALKE)₅ Is a Cell Penetrating Peptide that Enhances the Intracellular Delivery of Proteins.

Li J, Tuma J, Han H, Kim H, Wilson RC, Lee HY, Murthy N. Li J, et al. Among authors: han h. Adv Healthc Mater. 2022 May;11(9):e2102118. doi: 10.1002/adhm.202102118. Epub 2021 Dec 16. Adv Healthc Mater. 2022. PMID: 34861744 Free PMC article.

6

Acid-Sensitive Surfactants Enhance the Delivery of Nucleic Acids.

Røise JJ, Han H, Li J, Kerr DL, Taing C, Behrouzi K, He M, Ruan E, Chan LY, Espinoza EM, Reinhard S, Thakker K, Kwon J, Mofrad MRK, Murthy N. Røise JJ, et al. Among authors: han h. Mol Pharm. 2022 Jan 3;19(1):67-79. doi: 10.1021/acs.molpharmaceut.1c00579. Epub 2021 Dec 21. Mol Pharm. 2022. PMID: 34931518

7

A self-immolative linker that releases thiols detects penicillin amidase and nitroreductase with high sensitivity via absorption spectroscopy.

Espinoza EM, Røise JJ, He M, Li IC, Agatep AK, Udenyi P, Han H, Jackson N, Kerr DL, Chen D, Stentzel MR, Ruan E, Riley L, Murthy N. Espinoza EM, et al. Among authors: han h. Chem Commun (Camb). 2022 Mar 3;58(19):3166-3169. doi: 10.1039/d1cc05322a. Chem Commun (Camb). 2022. PMID: 35170593 Free PMC article.

8

In utero delivery of mRNA to the heart, diaphragm and muscle with lipid nanoparticles.

Gao K, Li J, Song H, Han H, Wang Y, Yin B, Farmer DL, Murthy N, Wang A. Gao K, et al. Among authors: han h. Bioact Mater. 2023 Feb 17;25:387-398. doi: 10.1016/j.bioactmat.2023.02.011. eCollection 2023 Jul. Bioact Mater. 2023. PMID: 36844366 Free PMC article.

9

Lipid Nanoparticles Deliver mRNA to the Brain after an Intracerebral Injection.

Tuma J, Chen YJ, Collins MG, Paul A, Li J, Han H, Sharma R, Murthy N, Lee HY. Tuma J, et al. Among authors: han h. Biochemistry. 2023 Dec 19;62(24):3533-3547. doi: 10.1021/acs.biochem.3c00371. Epub 2023 Sep 20. Biochemistry. 2023. PMID: 37729550 Free PMC article.

10

Lung and liver editing by lipid nanoparticle delivery of a stable CRISPR-Cas9 RNP.

Chen K, Han H, Zhao S, Xu B, Yin B, Trinidad M, Burgstone BW, Murthy N, Doudna JA. Chen K, et al. Among authors: han h. bioRxiv [Preprint]. 2023 Nov 15:2023.11.15.566339. doi: 10.1101/2023.11.15.566339. bioRxiv. 2023. Update in: Nat Biotechnol. 2024 Oct 16. doi: 10.1038/s41587-024-02437-3. PMID: 38014175 Free PMC article. Updated. Preprint.

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