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Hyperglycemic environments directly compromise intestinal epithelial barrier function in an organoid model and hyaluronan (∼35 kDa) protects via a layilin dependent mechanism.
Jatana S, Abbadi A, West GA, Ponti AK, Braga-Neto MB, Smith JL, Marino-Melendez A, Willard B, Nagy LE, Motte C. Jatana S, et al. Among authors: motte c. Matrix Biol. 2024 Nov;133:116-133. doi: 10.1016/j.matbio.2024.08.007. Epub 2024 Aug 24. Matrix Biol. 2024. PMID: 39187208 Free article.
The protein kinase R modifies gut physiology to limit colitis.
Yim HCH, Chakrabarti A, Kessler S, Morimoto H, Wang D, Sooraj D, Ahmed AU, de la Motte C, Silverman RH, Williams BR, Sadler AJ. Yim HCH, et al. Among authors: de la motte c. Front Immunol. 2023 Feb 17;14:1106737. doi: 10.3389/fimmu.2023.1106737. eCollection 2023. Front Immunol. 2023. PMID: 36875104 Free PMC article.
M1 Macrophages Induce Protumor Inflammation in Melanoma Cells through TNFR-NF-κB Signaling.
Kainulainen K, Takabe P, Heikkinen S, Aaltonen N, de la Motte C, Rauhala L, Durst FC, Oikari S, Hukkanen T, Rahunen E, Ikonen E, Hartikainen JM, Ketola K, Pasonen-Seppänen S. Kainulainen K, et al. Among authors: de la motte c. J Invest Dermatol. 2022 Nov;142(11):3041-3051.e10. doi: 10.1016/j.jid.2022.04.024. Epub 2022 May 14. J Invest Dermatol. 2022. PMID: 35580697 Free article.
Human intelectin-1 (ITLN1) genetic variation and intestinal expression.
Nonnecke EB, Castillo PA, Dugan AE, Almalki F, Underwood MA, De La Motte CA, Yuan W, Lu W, Shen B, Johansson MEV, Kiessling LL, Hollox EJ, Lönnerdal B, Bevins CL. Nonnecke EB, et al. Among authors: de la motte ca. Sci Rep. 2021 Jun 18;11(1):12889. doi: 10.1038/s41598-021-92198-9. Sci Rep. 2021. PMID: 34145348 Free PMC article.
Hyaluronan synthesis inhibition impairs antigen presentation and delays transplantation rejection.
Marshall PL, Nagy N, Kaber G, Barlow GL, Ramesh A, Xie BJ, Linde MH, Haddock NL, Lester CA, Tran QL, de Vries CR, Hargil A, Malkovskiy AV, Gurevich I, Martinez HA, Kuipers HF, Yadava K, Zhang X, Evanko SP, Gebe JA, Wang X, Vernon RB, de la Motte C, Wight TN, Engleman EG, Krams SM, Meyer EH, Bollyky PL. Marshall PL, et al. Among authors: de la motte c. Matrix Biol. 2021 Feb;96:69-86. doi: 10.1016/j.matbio.2020.12.001. Epub 2020 Dec 5. Matrix Biol. 2021. PMID: 33290836 Free PMC article.
Selective deletion of MyD88 signaling in α-SMA positive cells ameliorates experimental intestinal fibrosis via post-transcriptional regulation.
Zhao S, Dejanovic D, Yao P, Bhilocha S, Sadler T, Schirbel A, West G, Doyon G, Lopez R, Mao R, Kurada S, El Ouali S, Grassl G, Fox PL, Cruise M, Worthley DL, de la Motte C, Fiocchi C, Rieder F. Zhao S, et al. Among authors: de la motte c. Mucosal Immunol. 2020 Jul;13(4):665-678. doi: 10.1038/s41385-020-0259-9. Epub 2020 Feb 4. Mucosal Immunol. 2020. PMID: 32020030 Free PMC article.
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