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Evaluation of elexacaftor-tezacaftor-ivacaftor treatment in individuals with cystic fibrosis and CFTRN1303K in the USA: a prospective, multicentre, open-label, single-arm trial.
Solomon GM, Linnemann RW, Rich R, Streby A, Buehler B, Hunter E, Vijaykumar K, Hunt WR, Brewington JJ, Rab A, Bai SP, Westbrook AL, McNicholas-Bevensee C, Hong J, Manfredi C, Barilla C, Suzuki S, Davis BR, Sorscher EJ. Solomon GM, et al. Among authors: sorscher ej. Lancet Respir Med. 2024 Aug 26:S2213-2600(24)00205-4. doi: 10.1016/S2213-2600(24)00205-4. Online ahead of print. Lancet Respir Med. 2024. PMID: 39208836
Elexacaftor/VX-445-mediated CFTR interactome remodeling reveals differential correction driven by mutation-specific translational dynamics.
Kim M, McDonald EF, Sabusap CMP, Timalsina B, Joshi D, Hong JS, Rab A, Sorscher EJ, Plate L. Kim M, et al. Among authors: sorscher ej. bioRxiv [Preprint]. 2023 Feb 4:2023.02.04.527134. doi: 10.1101/2023.02.04.527134. bioRxiv. 2023. Update in: J Biol Chem. 2023 Oct;299(10):105242. doi: 10.1016/j.jbc.2023.105242. PMID: 36778339 Free PMC article. Updated. Preprint.
Relationships between genomic dissipation and de novo SNP evolution.
Plyler ZE, McAtee CW, Hill AE, Crowley MR, Tindall JM, Tindall SR, Joshi D, Sorscher EJ. Plyler ZE, et al. Among authors: sorscher ej. PLoS One. 2024 May 16;19(5):e0303257. doi: 10.1371/journal.pone.0303257. eCollection 2024. PLoS One. 2024. PMID: 38753830 Free PMC article.
Nucleic acid-based drugs for patients with solid tumours.
Huayamares SG, Loughrey D, Kim H, Dahlman JE, Sorscher EJ. Huayamares SG, et al. Among authors: sorscher ej. Nat Rev Clin Oncol. 2024 Jun;21(6):407-427. doi: 10.1038/s41571-024-00883-1. Epub 2024 Apr 8. Nat Rev Clin Oncol. 2024. PMID: 38589512 Review.
Development of robust antiviral assays using relevant apical-out human airway organoids.
Lee JH, LeCher JC, Parigoris E, Shinagawa N, Sentosa J, Manfredi C, Goh SL, De R, Tao S, Zandi K, Amblard F, Sorscher EJ, Spence JR, Tirouvanziam R, Schinazi RF, Takayama S. Lee JH, et al. Among authors: sorscher ej. bioRxiv [Preprint]. 2024 Jul 12:2024.01.02.573939. doi: 10.1101/2024.01.02.573939. bioRxiv. 2024. PMID: 38260306 Free PMC article. Preprint.
A Novel 7H-[1,2,4]Triazolo[3,4-b]thiadiazine-based Cystic Fibrosis Transmembrane Conductance Regulator Potentiator Directed toward Treatment of Cystic Fibrosis.
Rab A, Yang X, Tracy WF, Hong JS, Joshi D, Manfredi C, Ponnaluri SS, Kolykhalov AA, Qui M, Fu H, Du Y, Davies HML, Sorscher EJ. Rab A, et al. Among authors: sorscher ej. ACS Med Chem Lett. 2023 Sep 20;14(10):1338-1343. doi: 10.1021/acsmedchemlett.3c00155. eCollection 2023 Oct 12. ACS Med Chem Lett. 2023. PMID: 37849531 Free PMC article.
Mechanisms by which the cystic fibrosis transmembrane conductance regulator may influence SARS-CoV-2 infection and COVID-19 disease severity.
Tedbury PR, Manfredi C, Degenhardt F, Conway J, Horwath MC, McCracken C, Sorscher AJ, Moreau S, Wright C, Edwards C, Brewer J, Guarner J, de Wit E, Williamson BN, Suthar MS, Ong YT, Roback JD, Alter DN, Holter JC, Karlsen TH, Sacchi N, Romero-Gómez M, Invernizzi P, Fernández J, Buti M, Albillos A, Julià A, Valenti L, Asselta R, Banales JM, Bujanda L, de Cid R, Franke A; Severe COVID-19 GWAS group; Sarafianos SG, Hong JS, Sorscher EJ, Ehrhardt A. Tedbury PR, et al. Among authors: sorscher ej. FASEB J. 2023 Nov;37(11):e23220. doi: 10.1096/fj.202300077R. FASEB J. 2023. PMID: 37801035 Free PMC article.
192 results