Chen SY - Search Results

1

Screening Privileged Alkyl Guanidinium Motifs under Host-Mimicking Conditions Reveals a Novel Antibiotic with an Unconventional Mode of Action.

Schum D, Elsen FAV, Ruddell S, Schorpp K, Junca H, Müsken M, Chen SY, Fiedler MK, Pickl T, Pieper DH, Hadian K, Zacharias M, Sieber SA. Schum D, et al. Among authors: chen sy. JACS Au. 2024 Jul 16;4(8):3125-3134. doi: 10.1021/jacsau.4c00449. eCollection 2024 Aug 26. JACS Au. 2024. PMID: 39211621 Free PMC article.

2

What Makes a Good Protein-Protein Interaction Stabilizer: Analysis and Application of the Dual-Binding Mechanism.

Chen SY, Zacharias M. Chen SY, et al. ACS Cent Sci. 2023 Apr 14;9(5):969-979. doi: 10.1021/acscentsci.3c00003. eCollection 2023 May 24. ACS Cent Sci. 2023. PMID: 37252344 Free PMC article.

3

Unraveling the mechanism of small molecule induced activation of Staphylococcus aureus signal peptidase IB.

Chen SY, Fiedler MK, Gronauer TF, Omelko O, von Wrisberg MK, Wang T, Schneider S, Sieber SA, Zacharias M. Chen SY, et al. Commun Biol. 2024 Jul 24;7(1):895. doi: 10.1038/s42003-024-06575-x. Commun Biol. 2024. PMID: 39043865 Free PMC article.

4

An internal docking site stabilizes substrate binding to γ-secretase: Analysis by molecular dynamics simulations.

Chen SY, Zacharias M. Chen SY, et al. Biophys J. 2022 Jun 21;121(12):2330-2344. doi: 10.1016/j.bpj.2022.05.023. Epub 2022 May 20. Biophys J. 2022. PMID: 35598043 Free PMC article.

5

A Chemical Proteomic Strategy Reveals Inhibitors of Lipoate Salvage in Bacteria and Parasites.

Dienemann JN, Chen SY, Hitzenberger M, Sievert ML, Hacker SM, Prigge ST, Zacharias M, Groll M, Sieber SA. Dienemann JN, et al. Among authors: chen sy. Angew Chem Int Ed Engl. 2023 Aug 1;62(31):e202304533. doi: 10.1002/anie.202304533. Epub 2023 Jun 26. Angew Chem Int Ed Engl. 2023. PMID: 37249408 Free PMC article.

6

How Mutations Perturb γ-Secretase Active Site Studied by Free Energy Simulations.

Chen SY, Zacharias M. Chen SY, et al. ACS Chem Neurosci. 2020 Oct 21;11(20):3321-3332. doi: 10.1021/acschemneuro.0c00440. Epub 2020 Oct 6. ACS Chem Neurosci. 2020. PMID: 32960571

7

How Modulator Binding at the Amyloidβ-γ-Secretase Interface Enhances Substrate Binding and Attenuates Membrane Distortion.

Chen SY, Koch M, Chávez-Gutiérrez L, Zacharias M. Chen SY, et al. J Med Chem. 2023 Dec 28;66(24):16772-16782. doi: 10.1021/acs.jmedchem.3c01480. Epub 2023 Dec 7. J Med Chem. 2023. PMID: 38059872

8

Active site geometry stabilization of a presenilin homolog by the lipid bilayer promotes intramembrane proteolysis.

Feilen LP, Chen SY, Fukumori A, Feederle R, Zacharias M, Steiner H. Feilen LP, et al. Among authors: chen sy. Elife. 2022 May 17;11:e76090. doi: 10.7554/eLife.76090. Elife. 2022. PMID: 35579427 Free PMC article.

9

Enzyme-substrate hybrid β-sheet controls geometry and water access to the γ-secretase active site.

Chen SY, Feilen LP, Chávez-Gutiérrez L, Steiner H, Zacharias M. Chen SY, et al. Commun Biol. 2023 Jun 24;6(1):670. doi: 10.1038/s42003-023-05039-y. Commun Biol. 2023. PMID: 37355752 Free PMC article.

10

APP substrate ectodomain defines amyloid-β peptide length by restraining γ-secretase processivity and facilitating product release.

Koch M, Enzlein T, Chen SY, Petit D, Lismont S, Zacharias M, Hopf C, Chávez-Gutiérrez L. Koch M, et al. Among authors: chen sy. EMBO J. 2023 Dec 1;42(23):e114372. doi: 10.15252/embj.2023114372. Epub 2023 Oct 18. EMBO J. 2023. PMID: 37853914 Free PMC article.

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