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440 results

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A feasibility study of controlled human infection with intradermal Bacillus Calmette-Guérin (BCG) injection: Pilot BCG controlled human infection model.
Carter E, Morton B, ElSafadi D, Jambo K, Kenny-Nyazika T, Hyder-Wright A, Chiwala G, Chikaonda T, Chirwa AE, Gonzalez Sanchez J, Yip V, Biagini G, Pennington SH, Saunderson P, Farrar M, Myerscough C, Collins AM, Gordon SB, Ferreira DM. Carter E, et al. Among authors: farrar m. Wellcome Open Res. 2024 Jun 5;8:424. doi: 10.12688/wellcomeopenres.19811.2. eCollection 2023. Wellcome Open Res. 2024. PMID: 39219857 Free PMC article.
Serotype 3 Experimental Human Pneumococcal Challenge (EHPC) study protocol: dose ranging and reproducibility in a healthy volunteer population (challenge 3).
Hazenberg P, Robinson RE, Farrar M, Solorzano C, Hyder-Wright A, Liatsikos K, Brunning J, Fleet H, Bettam A, Howard A, Kenny-Nyazika T, Urban B, Mitsi E, El Safadi D, Davies K, Lesosky M, Gordon SB, Ferreira DM, Collins AM. Hazenberg P, et al. Among authors: farrar m. BMJ Open. 2024 Jan 10;14(1):e075948. doi: 10.1136/bmjopen-2023-075948. BMJ Open. 2024. PMID: 38199622 Free PMC article.
Protocol for a phase IV double-blind randomised controlled trial to investigate the effect of the 13-valent pneumococcal conjugate vaccine and the 23-valent pneumococcal polysaccharide vaccine on pneumococcal colonisation using the experimental human pneumococcal challenge model in healthy adults (PREVENTING PNEUMO 2).
Liatsikos K, Hyder-Wright A, Pojar S, Chen T, Wang D, Davies K, Myerscough C, Reine J, Robinson RE, Urban B, Mitsi E, Solorzano C, Gordon SB, Quinn A, Pan K, Anderson AS, Theilacker C, Begier E, Gessner BD, Collins A, Ferreira DM; PNEUMO 2 study group. Liatsikos K, et al. BMJ Open. 2022 Jul 7;12(7):e062109. doi: 10.1136/bmjopen-2022-062109. BMJ Open. 2022. PMID: 35798520 Free PMC article.
Human Infection Challenge with Serotype 3 Pneumococcus.
Robinson RE, Mitsi E, Nikolaou E, Pojar S, Chen T, Reiné J, Nyazika TK, Court J, Davies K, Farrar M, Gonzalez-Dias P, Hamilton J, Hill H, Hitchins L, Howard A, Hyder-Wright A, Lesosky M, Liatsikos K, Matope A, McLenaghan D, Myerscough C, Murphy A, Solórzano C, Wang D, Burhan H, Gautam M, Begier E, Theilacker C, Beavon R, Anderson AS, Gessner BD, Gordon SB, Collins AM, Ferreira DM. Robinson RE, et al. Among authors: farrar m. Am J Respir Crit Care Med. 2022 Dec 1;206(11):1379-1392. doi: 10.1164/rccm.202112-2700OC. Am J Respir Crit Care Med. 2022. PMID: 35802840
A Randomized Controlled Clinical Trial of Nasal Immunization with Live Virulence Attenuated Streptococcus pneumoniae Strains Using Human Infection Challenge.
Hill H, Mitsi E, Nikolaou E, Blizard A, Pojar S, Howard A, Hyder-Wright A, Devin J, Reiné J, Robinson R, Solórzano C, Jochems SP, Kenny-Nyazika T, Ramos-Sevillano E, Weight CM, Myerscough C, McLenaghan D, Morton B, Gibbons E, Farrar M, Randles V, Burhan H, Chen T, Shandling AD, Campo JJ, Heyderman RS, Gordon SB, Brown JS, Collins AM, Ferreira DM. Hill H, et al. Among authors: farrar m. Am J Respir Crit Care Med. 2023 Oct 15;208(8):868-878. doi: 10.1164/rccm.202302-0222OC. Am J Respir Crit Care Med. 2023. PMID: 37556679 Clinical Trial.
RSV and rhinovirus increase pneumococcal carriage acquisition and density, whereas nasal inflammation is associated with bacterial shedding.
Mitsi E, Nikolaou E, Goncalves A, Blizard A, Hill H, Farrar M, Hyder-Wright A, Akeju O, Hamilton J, Howard A, Elterish F, Solorzano C, Robinson R, Reiné J, Collins AM, Gordon SB, Moxon RE, Weiser JN, Bogaert D, Ferreira DM. Mitsi E, et al. Among authors: farrar m. Cell Host Microbe. 2024 Sep 11;32(9):1608-1620.e4. doi: 10.1016/j.chom.2024.07.024. Epub 2024 Aug 23. Cell Host Microbe. 2024. PMID: 39181126
Respiratory mucosal immune memory to SARS-CoV-2 after infection and vaccination.
Mitsi E, Diniz MO, Reiné J, Collins AM, Robinson RE, Hyder-Wright A, Farrar M, Liatsikos K, Hamilton J, Onyema O, Urban BC, Solórzano C, Belij-Rammerstorfer S, Sheehan E, Lambe T, Draper SJ, Weiskopf D, Sette A, Maini MK, Ferreira DM. Mitsi E, et al. Among authors: farrar m. Nat Commun. 2023 Oct 26;14(1):6815. doi: 10.1038/s41467-023-42433-w. Nat Commun. 2023. PMID: 37884506 Free PMC article.
Detection of SARS-CoV-2 infection by saliva and nasopharyngeal sampling in frontline healthcare workers: An observational cohort study.
Walker NF, Byrne RL, Howard A, Nikolaou E, Farrar M, Glynn S, Cheliotis KS, Cubas Atienzar AI, Davies K, Reiné J, Rashid-Gardner Z, German EL, Solórzano C, Blandamer T, Hitchins L, Myerscough C, Gessner BD, Begier E, Collins AM, Beadsworth M, Todd S, Hill H, Houlihan CF, Nastouli E, Adams ER, Mitsi E, Ferreira DM; SAFER investigators. Walker NF, et al. Among authors: farrar m. PLoS One. 2023 Jan 27;18(1):e0280908. doi: 10.1371/journal.pone.0280908. eCollection 2023. PLoS One. 2023. PMID: 36706119 Free PMC article.
Streptococcus pneumoniae colonization associates with impaired adaptive immune responses against SARS-CoV-2.
Mitsi E, Reiné J, Urban BC, Solórzano C, Nikolaou E, Hyder-Wright AD, Pojar S, Howard A, Hitchins L, Glynn S, Farrar MC, Liatsikos K, Collins AM, Walker NF, Hill HC, German EL, Cheliotis KS, Byrne RL, Williams CT, Cubas-Atienzar AI, Fletcher TE, Adams ER, Draper SJ, Pulido D, Beavon R, Theilacker C, Begier E, Jodar L, Gessner BD, Ferreira DM. Mitsi E, et al. Among authors: farrar mc. J Clin Invest. 2022 Apr 1;132(7):e157124. doi: 10.1172/JCI157124. J Clin Invest. 2022. PMID: 35139037 Free PMC article.
Outcomes of early-treated infants with spinal muscular atrophy: A multicenter, retrospective cohort study.
Goedeker NL, Rogers A, Fisher M, Arya K, Brandsema JF, Farah H, Farrar MA, Felker MV, Gibbons M, Hamid OA, Harmelink M, Herbert K, Kichula E, King K, Lakhotia A, Lee BH, Kuntz NL, Parsons J, Rehborg R, Veerapaniyan A, Zaidman CM. Goedeker NL, et al. Among authors: farrar ma. Muscle Nerve. 2024 Oct 6. doi: 10.1002/mus.28267. Online ahead of print. Muscle Nerve. 2024. PMID: 39370660
440 results