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Chemical, Biochemical, Cellular, and Physiological Characterization of Leucettinib-21, a Down Syndrome and Alzheimer's Disease Drug Candidate.
Lindberg MF, Deau E, Miege F, Greverie M, Roche D, George N, George P, Merlet L, Gavard J, Brugman SJT, Aret E, Tinnemans P, de Gelder R, Sadownik J, Verhofstad E, Sleegers D, Santangelo S, Dairou J, Fernandez-Blanco Á, Dierssen M, Krämer A, Knapp S, Meijer L. Lindberg MF, et al. Among authors: roche d. J Med Chem. 2023 Dec 14;66(23):15648-15670. doi: 10.1021/acs.jmedchem.3c01888. Epub 2023 Dec 5. J Med Chem. 2023. PMID: 38051674
First fragment-based screening identifies new chemotypes inhibiting ERAP1-metalloprotease.
Fougiaxis V, Barcherini V, Petrovic MM, Sierocki P, Warenghem S, Leroux F, Bou Karroum N, Petit-Cancelier F, Rodeschini V, Roche D, Deprez B, Deprez-Poulain R. Fougiaxis V, et al. Among authors: roche d. Eur J Med Chem. 2024 Sep 30;280:116926. doi: 10.1016/j.ejmech.2024.116926. Online ahead of print. Eur J Med Chem. 2024. PMID: 39369482 Free article.
Therapeutic potential of compounds targeting SARS-CoV-2 helicase.
Halma MTJ, Wever MJA, Abeln S, Roche D, Wuite GJL. Halma MTJ, et al. Among authors: roche d. Front Chem. 2022 Dec 6;10:1062352. doi: 10.3389/fchem.2022.1062352. eCollection 2022. Front Chem. 2022. PMID: 36561139 Free PMC article.
Affinity selection mass spectrometry speeding drug discovery.
Prudent R, Lemoine H, Walsh J, Roche D. Prudent R, et al. Among authors: roche d. Drug Discov Today. 2023 Nov;28(11):103760. doi: 10.1016/j.drudis.2023.103760. Epub 2023 Sep 1. Drug Discov Today. 2023. PMID: 37660985 Review.
449 results