Lane JR - Search Results

1

The chemokine receptor CCR8 is not a high-affinity receptor for the human chemokine CCL18.

Hussain K, Lim HD, Devkota SR, Kemp-Harper BK, Lane JR, Canals M, Pease JE, Stone MJ. Hussain K, et al. Among authors: lane jr. PLoS One. 2024 Sep 11;19(9):e0305312. doi: 10.1371/journal.pone.0305312. eCollection 2024. PLoS One. 2024. PMID: 39259753 Free PMC article.

2

Influence of Chemokine N-Terminal Modification on Biased Agonism at the Chemokine Receptor CCR1.

Sanchez J, Lane JR, Canals M, Stone MJ. Sanchez J, et al. Among authors: lane jr. Int J Mol Sci. 2019 May 15;20(10):2417. doi: 10.3390/ijms20102417. Int J Mol Sci. 2019. PMID: 31096719 Free PMC article.

3

Key determinants of selective binding and activation by the monocyte chemoattractant proteins at the chemokine receptor CCR2.

Huma ZE, Sanchez J, Lim HD, Bridgford JL, Huang C, Parker BJ, Pazhamalil JG, Porebski BT, Pfleger KDG, Lane JR, Canals M, Stone MJ. Huma ZE, et al. Among authors: lane jr. Sci Signal. 2017 May 23;10(480):eaai8529. doi: 10.1126/scisignal.aai8529. Sci Signal. 2017. PMID: 28536301

4

Evaluation and extension of the two-site, two-step model for binding and activation of the chemokine receptor CCR1.

Sanchez J, E Huma Z, Lane JR, Liu X, Bridgford JL, Payne RJ, Canals M, Stone MJ. Sanchez J, et al. Among authors: lane jr. J Biol Chem. 2019 Mar 8;294(10):3464-3475. doi: 10.1074/jbc.RA118.006535. Epub 2018 Dec 19. J Biol Chem. 2019. PMID: 30567735 Free PMC article.

5

Systematic Assessment of Chemokine Signaling at Chemokine Receptors CCR4, CCR7 and CCR10.

Lim HD, Lane JR, Canals M, Stone MJ. Lim HD, et al. Among authors: lane jr. Int J Mol Sci. 2021 Apr 19;22(8):4232. doi: 10.3390/ijms22084232. Int J Mol Sci. 2021. PMID: 33921794 Free PMC article.

6

The in vitro functional profiles of fentanyl and nitazene analogs at the μ-opioid receptor - high efficacy is dangerous regardless of signaling bias.

Tsai MM, Chen L, Baumann MH, Canals M, Javitch JA, Lane JR, Shi L. Tsai MM, et al. Among authors: lane jr. bioRxiv [Preprint]. 2023 Nov 15:2023.11.10.566672. doi: 10.1101/2023.11.10.566672. bioRxiv. 2023. Update in: ACS Chem Neurosci. 2024 Feb 21;15(4):854-867. doi: 10.1021/acschemneuro.3c00750. PMID: 38014284 Free PMC article. Updated. Preprint.

7

Sequential conformational rearrangements dictate the dynamics of class C GPCR activation.

Lane JR, Canals M. Lane JR, et al. Sci Signal. 2012 Nov 20;5(251):pe51. doi: 10.1126/scisignal.2003503. Sci Signal. 2012. PMID: 23169816

8

GRKs as Key Modulators of Opioid Receptor Function.

Lemel L, Lane JR, Canals M. Lemel L, et al. Among authors: lane jr. Cells. 2020 Nov 2;9(11):2400. doi: 10.3390/cells9112400. Cells. 2020. PMID: 33147802 Free PMC article. Review.

9

In Vitro Functional Profiling of Fentanyl and Nitazene Analogs at the μ-Opioid Receptor Reveals High Efficacy for Gi Protein Signaling.

Tsai MM, Chen L, Baumann MH, Canals M, Javitch JA, Lane JR, Shi L. Tsai MM, et al. Among authors: lane jr. ACS Chem Neurosci. 2024 Feb 21;15(4):854-867. doi: 10.1021/acschemneuro.3c00750. Epub 2024 Feb 12. ACS Chem Neurosci. 2024. PMID: 38345920

10

A Monod-Wyman-Changeux mechanism can explain G protein-coupled receptor (GPCR) allosteric modulation.

Canals M, Lane JR, Wen A, Scammells PJ, Sexton PM, Christopoulos A. Canals M, et al. Among authors: lane jr. J Biol Chem. 2012 Jan 2;287(1):650-659. doi: 10.1074/jbc.M111.314278. Epub 2011 Nov 15. J Biol Chem. 2012. PMID: 22086918 Free PMC article.

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