Nadel CM - Search Results

1

Phosphorylation of tau at a single residue inhibits binding to the E3 ubiquitin ligase, CHIP.

Nadel CM, Pokhrel S, Wucherer K, Oehler A, Thwin AC, Basu K, Callahan MD, Southworth DR, Mordes DA, Craik CS, Gestwicki JE. Nadel CM, et al. Nat Commun. 2024 Sep 12;15(1):7972. doi: 10.1038/s41467-024-52075-1. Nat Commun. 2024. PMID: 39266525 Free PMC article.

2

Phosphorylation of a Cleaved Tau Proteoform at a Single Residue Inhibits Binding to the E3 Ubiquitin Ligase, CHIP.

Nadel CM, Wucherer K, Oehler A, Thwin AC, Basu K, Callahan MD, Southworth DR, Mordes DA, Craik CS, Gestwicki JE. Nadel CM, et al. bioRxiv [Preprint]. 2023 Aug 16:2023.08.16.553575. doi: 10.1101/2023.08.16.553575. bioRxiv. 2023. Update in: Nat Commun. 2024 Sep 12;15(1):7972. doi: 10.1038/s41467-024-52075-1. PMID: 37645969 Free PMC article. Updated. Preprint.

3

The E3 Ubiquitin Ligase, CHIP/STUB1, Inhibits Aggregation of Phosphorylated Proteoforms of Microtubule-associated Protein Tau (MAPT).

Nadel CM, Thwin AC, Callahan M, Lee K, Connelly E, Craik CS, Southworth DR, Gestwicki JE. Nadel CM, et al. J Mol Biol. 2023 Jun 1;435(11):168026. doi: 10.1016/j.jmb.2023.168026. Epub 2023 Jun 16. J Mol Biol. 2023. PMID: 37330289 Free PMC article.

4

Two distinct classes of cochaperones compete for the EEVD motif in heat shock protein 70 to tune its chaperone activities.

Johnson OT, Nadel CM, Carroll EC, Arhar T, Gestwicki JE. Johnson OT, et al. Among authors: nadel cm. J Biol Chem. 2022 Mar;298(3):101697. doi: 10.1016/j.jbc.2022.101697. Epub 2022 Feb 9. J Biol Chem. 2022. PMID: 35148989 Free PMC article.

5

The interactions of molecular chaperones with client proteins: why are they so weak?

Arhar T, Shkedi A, Nadel CM, Gestwicki JE. Arhar T, et al. Among authors: nadel cm. J Biol Chem. 2021 Nov;297(5):101282. doi: 10.1016/j.jbc.2021.101282. Epub 2021 Oct 6. J Biol Chem. 2021. PMID: 34624315 Free PMC article. Review.

6

The structure of an Hsp90-immunophilin complex reveals cochaperone recognition of the client maturation state.

Lee K, Thwin AC, Nadel CM, Tse E, Gates SN, Gestwicki JE, Southworth DR. Lee K, et al. Among authors: nadel cm. Mol Cell. 2021 Sep 2;81(17):3496-3508.e5. doi: 10.1016/j.molcel.2021.07.023. Epub 2021 Aug 10. Mol Cell. 2021. PMID: 34380015 Free PMC article.

7

Luminescence complementation assay for measurement of binding to protein C-termini in live cells.

Nadel CM, Ran X, Gestwicki JE. Nadel CM, et al. Anal Biochem. 2020 Dec 15;611:113947. doi: 10.1016/j.ab.2020.113947. Epub 2020 Sep 10. Anal Biochem. 2020. PMID: 32918866 Free PMC article.

8

Osmolyte accumulation regulates the SUMOylation and inclusion dynamics of the prionogenic Cyc8-Tup1 transcription corepressor.

Nadel CM, Mackie TD, Gardner RG. Nadel CM, et al. PLoS Genet. 2019 Apr 22;15(4):e1008115. doi: 10.1371/journal.pgen.1008115. eCollection 2019 Apr. PLoS Genet. 2019. PMID: 31009461 Free PMC article.

9

Rewiring MAP kinases in Saccharomyces cerevisiae to regulate novel targets through ubiquitination.

Groves B, Khakhar A, Nadel CM, Gardner RG, Seelig G. Groves B, et al. Among authors: nadel cm. Elife. 2016 Aug 15;5:e15200. doi: 10.7554/eLife.15200. Elife. 2016. PMID: 27525484 Free PMC article.

10

Dynamic Sumoylation of a Conserved Transcription Corepressor Prevents Persistent Inclusion Formation during Hyperosmotic Stress.

Oeser ML, Amen T, Nadel CM, Bradley AI, Reed BJ, Jones RD, Gopalan J, Kaganovich D, Gardner RG. Oeser ML, et al. Among authors: nadel cm. PLoS Genet. 2016 Jan 22;12(1):e1005809. doi: 10.1371/journal.pgen.1005809. eCollection 2016 Jan. PLoS Genet. 2016. PMID: 26800527 Free PMC article.

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