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The ATOM-Seq sequence capture panel can accurately predict microsatellite instability status in formalin-fixed tumour samples, alongside routine gene mutation testing.
Srihar K, Gusnanto A, Richman SD, West NP, Galvin L, Bottomley D, Hemmings G, Glover A, Natarajan S, Miller R, Arif S, Rossington H, Dunwell TL, Dailey SC, Fontarum G, George A, Wu W, Quirke P, Wood HM. Srihar K, et al. Among authors: west np. Sci Rep. 2024 Sep 19;14(1):21870. doi: 10.1038/s41598-024-72419-7. Sci Rep. 2024. PMID: 39300198 Free PMC article.
Lynch syndrome screening in colorectal cancer: results of a prospective 2-year regional programme validating the NICE diagnostics guidance pathway throughout a 5.2-million population.
West NP, Gallop N, Kaye D, Glover A, Young C, Hutchins GGA, Brockmoeller SF, Westwood AC, Rossington H, Quirke P; Yorkshire Cancer Research Bowel Cancer Improvement Programme Group. West NP, et al. Histopathology. 2021 Nov;79(5):690-699. doi: 10.1111/his.14390. Epub 2021 Jun 21. Histopathology. 2021. PMID: 33872400 Free article.
Generalizable biomarker prediction from cancer pathology slides with self-supervised deep learning: A retrospective multi-centric study.
Niehues JM, Quirke P, West NP, Grabsch HI, van Treeck M, Schirris Y, Veldhuizen GP, Hutchins GGA, Richman SD, Foersch S, Brinker TJ, Fukuoka J, Bychkov A, Uegami W, Truhn D, Brenner H, Brobeil A, Hoffmeister M, Kather JN. Niehues JM, et al. Among authors: west np. Cell Rep Med. 2023 Apr 18;4(4):100980. doi: 10.1016/j.xcrm.2023.100980. Epub 2023 Mar 22. Cell Rep Med. 2023. PMID: 36958327 Free PMC article.
Artificial intelligence for detection of microsatellite instability in colorectal cancer-a multicentric analysis of a pre-screening tool for clinical application.
Echle A, Ghaffari Laleh N, Quirke P, Grabsch HI, Muti HS, Saldanha OL, Brockmoeller SF, van den Brandt PA, Hutchins GGA, Richman SD, Horisberger K, Galata C, Ebert MP, Eckardt M, Boutros M, Horst D, Reissfelder C, Alwers E, Brinker TJ, Langer R, Jenniskens JCA, Offermans K, Mueller W, Gray R, Gruber SB, Greenson JK, Rennert G, Bonner JD, Schmolze D, Chang-Claude J, Brenner H, Trautwein C, Boor P, Jaeger D, Gaisa NT, Hoffmeister M, West NP, Kather JN. Echle A, et al. Among authors: west np. ESMO Open. 2022 Apr;7(2):100400. doi: 10.1016/j.esmoop.2022.100400. Epub 2022 Mar 2. ESMO Open. 2022. PMID: 35247870 Free PMC article.
Clinical-Grade Detection of Microsatellite Instability in Colorectal Tumors by Deep Learning.
Echle A, Grabsch HI, Quirke P, van den Brandt PA, West NP, Hutchins GGA, Heij LR, Tan X, Richman SD, Krause J, Alwers E, Jenniskens J, Offermans K, Gray R, Brenner H, Chang-Claude J, Trautwein C, Pearson AT, Boor P, Luedde T, Gaisa NT, Hoffmeister M, Kather JN. Echle A, et al. Among authors: west np. Gastroenterology. 2020 Oct;159(4):1406-1416.e11. doi: 10.1053/j.gastro.2020.06.021. Epub 2020 Jun 17. Gastroenterology. 2020. PMID: 32562722 Free PMC article.
Associations between AI-Assisted Tumor Amphiregulin and Epiregulin IHC and Outcomes from Anti-EGFR Therapy in the Routine Management of Metastatic Colorectal Cancer.
Williams CJM, Elliott F, Sapanara N, Aghaei F, Zhang L, Muranyi A, Yan D, Bai I, Zhao Z, Shires M, Wood HM, Richman SD, Hemmings G, Hale M, Bottomley D, Galvin L, Cartlidge C, Dance S, Bacon CM, Mansfield L, Young-Zvandasara K, Sudan A, Lambert K, Bibby I, Coupland SE, Montazeri A, Kipling N, Hughes K, Cross SS, Dewdney A, Pheasey L, Leng C, Gochera T, Mangham DC, Saunders M, Pritchard M, Stott H, Mukherjee A, Ilyas M, Silverman R, Hyland G, Sculthorpe D, Thornton K, Gould I, O'Callaghan A, Brown N, Turnbull S, Shaw L, Seymour MT, West NP, Seligmann JF, Singh S, Shanmugam K, Quirke P. Williams CJM, et al. Among authors: west np. Clin Cancer Res. 2023 Oct 13;29(20):4153-4165. doi: 10.1158/1078-0432.CCR-23-0859. Clin Cancer Res. 2023. PMID: 37363997 Free PMC article.
257 results