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Ticagrelor alters the membrane of Staphylococcus aureus and enhances the activity of vancomycin and daptomycin without eliciting cross-resistance.
Leeten K, Jacques N, Esquembre LA, Schneider DC, Straetener J, Henriksen C, Musumeci L, Putters F, Melo S, Sánchez-López E, Giera M, Penoy N, Piel G, Verlaine O, Amoroso A, Joris B, Slavetinsky CJ, Goffin E, Pirotte B, Frees D, Brötz-Oesterhelt H, Lancellotti P, Oury C. Leeten K, et al. mBio. 2024 Oct 16;15(10):e0132224. doi: 10.1128/mbio.01322-24. Epub 2024 Sep 23. mBio. 2024. PMID: 39311589 Free PMC article.
Protective Effect of Ticagrelor Against Infective Endocarditis Induced by Virulent Staphylococcus aureus in Mice.
Oury C, Meyers S, Jacques N, Leeten K, Jiang Z, Musumeci L, Lox M, Debuisson M, Goffin E, Pirotte B, Delvenne P, Nchimi A, Hubert C, Heptia M, Hubert P, Kuijpers MJE, Vanassche T, Martinod K, Verhamme P, Lancellotti P. Oury C, et al. Among authors: leeten k. JACC Basic Transl Sci. 2023 May 24;8(11):1439-1453. doi: 10.1016/j.jacbts.2023.02.003. eCollection 2023 Nov. JACC Basic Transl Sci. 2023. PMID: 38093743 Free PMC article.
A Clinically Selected Staphylococcus aureus clpP Mutant Survives Daptomycin Treatment by Reducing Binding of the Antibiotic and Adapting a Rod-Shaped Morphology.
Xu L, Henriksen C, Mebus V, Guérillot R, Petersen A, Jacques N, Jiang JH, Derks RJE, Sánchez-López E, Giera M, Leeten K, Stinear TP, Oury C, Howden BP, Peleg AY, Frees D. Xu L, et al. Among authors: leeten k. Antimicrob Agents Chemother. 2023 Jun 15;67(6):e0032823. doi: 10.1128/aac.00328-23. Epub 2023 May 15. Antimicrob Agents Chemother. 2023. PMID: 37184389 Free PMC article.